p-Anisidine 对甲氧基苯胺

CAS 104-94-9 MFCD00007864

化学结构图

104-94-9
SMILES: COC1CCC(N)CC1

化学属性

Mol. FormulaC7H9NO
Mol. Weight123
Density1.06
Autoignition Point959 °F
Boiling Point240-243
Melting Point56-59
Flash Point122°(251°F)
TSCAYes
Solubility微溶于水,溶于乙醇、乙醚、丙酮、苯等多数有机溶剂。
Appearance crystalline
Refractive index1.5559
Stability对光敏感

别名和识别编码

Chemical Namep-Anisidine
MDL NumberMFCD00007864
CAS Number104-94-9
EC Number203-254-2
Beilstein Registry Number471556
Synonym 1-Amino-4-methoxybenzene 1-Methoxy-4-amino-benzen (p-anisidin) 1-Methoxy-4-amino-benzene / p-anisidine 4-Aminoanisole 4-Aminoanisole; 4-Methoxyaniline; 4-Methoxybenzeneamine 4-Anisidine 4-Methoxy-phenylamine 4-Methoxyaminobenzol 4-Methoxyaniline 4-Methoxyphenylamine 4-methoxy-aniline 4-methoxy-benzenamin 4-methoxy-benzenamine 4-甲氧基苯胺(对茴香胺,对氨基苯甲醚) p-Anisidine LABOTEST-BB LTBB000468 Methyl 4-aminophenyl ether P-AMINOANISOLE PARA ANISIDINE p-Anisylamine 对氨基茴香醚 对甲氧基苯胺 对茴香胺 邻氨基本甲醚
PubChem Substance ID87562329
Merck Number667
Reaxys-RN471556
Chemical Name Translation对甲氧基苯胺
Wiswesser Line NotationZR DO1
LabNetwork Molecule IDLN00195921
InChIInChI=1S/C7H9NO/c1-9-7-4-2-6(8)3-5-7/h2-5H,8H2,1H3
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; ether; 1fragment
  • {SNA} Amines, Building Blocks, C7, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • An aromatic compound used in the detection of aldehydes or ketones in oils.

相关文献及参考

  • Short: II/27B
  • Merck:14,667
  • Short: II/5
  • Short: III/20a

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S1/2 None 上锁保管并避免儿童触及;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R33 Danger of cumulative effects 有累积作用的危险
  • R45 May cause cancer 可能致癌
  • R50 Very toxic to aquatic organisms 对水生生物极毒
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P301+P310+P330
  • P302+P350
  • P302+P352+P312+P361+P364
  • P304+P340+P311
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P307+P311
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P332+P313
  • P337+P313
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H301+H311+H331
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H301 Toxic if swallowed 吞食有毒
  • H350 May cause cancer 可能致癌
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSBZ5450000
Packing GroupIII
UN Number 2431/2811 2811 UN 2811 6.1/PG 3 UN2431
Hazard Codes 6.1 T+,N T+,N,Xi
Hazard Class6.1
Storage condition 密封避光保存 密封避光保存 充氩保存 2-8°C
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo
   Instituta.  (Leningrad, Russia) V.1-145, 1949-82.  Discontinued.
   Volume(issue)/page/year: 128,14,1979

TYPE OF TEST            : LD50 - Lethal

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene.  (Berlin, Ger.)
   V.1-18, 1930-61.  For publisher information, see IAEHDW.
   Volume(issue)/page/year: 15,447,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 806 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,900,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - other changes
   Blood - normocytic anemia
   Blood - other changes
REFERENCE :
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-

{h

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 196 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 202 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 392 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,193,1988

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION           : 780 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 272,161,1992

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 160 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

其他信息

  • 可燃性危险特性:明火可燃;
  • 毒性分级:中毒
  • 对甲氧基苯胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80080726 对甲氧基苯胺 100g 84.2元 2011/08/23 TA080202 对茴香胺 25g 187元 2011/04/16 A0487 对茴香胺 p-Anisidine 25G 175元
  • {Chemica
  • 方法一:(1)传统硫化钠法原料对硝基氯苯与甲醇、液碱进行甲氧基化反应,生成对硝基苯甲醚,用硫化钠还原对硝基苯甲醚,反应产物经分离、减压蒸馏后,得成
  • 方法一:(1)传统硫化钠法原料对硝基氯苯与甲醇、液碱进行甲氧基化反应,生成对硝基苯甲醚,用硫化钠还原对硝基苯甲醚,反应产物经分离、减压蒸馏后,得成品对氨基苯甲醚。在还原锅加入23%的硫化钠,搅拌加热至90℃,在4h内加入对硝基苯甲醚,加料温度控制在9
  • 方法一:(1)传统硫化钠法原料对硝基氯苯与甲醇、液碱进行甲氧
  • 检测方法:GC,NMR
  • TCI Shanghai:对氨基苯甲醚 p-Anisidine,>;98.0%(GC)(104-94-9)
  • 方法一:(1)传统硫化钠法原料对硝基氯苯与甲醇、
  • 上游原料:氢氧化钠 --> 甲醇 --> Α-球蛋白 --> 硫化钠 --> 4-硝基氯苯 --> 4-硝基苯甲醚
  • color:dark gray to brown
  • 防护措施:高毒。空气中最高容许浓度0.5mg/m3。防护方法参见“邻氨基苯甲醚”。
  • 用途一:用作染料和医药中间体
  • Acros Organics:4-甲氧基苯胺 p-Anisidine, 99%(104-94-9)
  • 常规方法:用铁桶包装,每桶净重200kg。贮存于通风、干燥处,避免日晒。按有毒危险品规定贮运。
  • 图谱信息:对甲氧基苯胺(104-94-9)红外图谱(IR2) 对甲氧基苯胺(104-94-9)红外图谱(IR1) 对甲氧基苯胺(104-94-9)质谱(MS) 对甲氧基苯胺(104-94-9)红外图谱(IR3) 对甲氧基苯胺(104-94-9)核磁图( 13 CNMR) 对甲氧基苯胺(104-94-9)核磁图( 1 HNMR)
  • 灭火剂:雾状水、
  • 下游产品:杂氮双环磷酸酯 --> 4-氨基嘧啶 --> 分散兰 79 --> 2-氰基-6-甲氧基苯并噻唑 --> 6-甲氧基喹啉 --> 6-羟基喹啉 --> 2-氨基-6-甲氧基苯并噻唑 --> 冰染重氮组分 1 --> 叔丁基-4-羟基苯甲醚 --> 5-甲氧基苯并咪唑 --> 5-甲氧基-3-吲唑羧酸 --> 碱性兰54 --> 1-(4-甲氧基苯基)哌嗪盐酸盐 --> 6-甲氧基苯并噻唑-2-羧酸 --> 1-(4-甲氧基苯基)哌嗪 --> 5-甲氧基靛红 --> 6-甲氧基-2-甲基喹啉 --> 对甲氧基苯基硫脲 --> 间-油酰氨基-邻-甲氧基苯磺酸钠,净洗剂MA,洗净剂SL --> 4-氯苯甲酸1-(4-甲氧苯基)酰肼 --> 4'-甲氧基乙酰苯胺 --> 2-(4-甲氧苯基)肼基磺酸钠 --> 凡拉明蓝盐B --> 四氟硼酸-4-甲氧基重氮苯正酯 --> 颜料红 190 --> 吲哚美辛 --> 对甲氧基苯异氰酸酯 --> 阳离子黄X-6G --> 2-羟基-N-(4-甲氧基苯基)-11H-苯并[a]咔唑-3-甲酰胺 --> 6-甲氧基-4-甲基喹啉 --> 4-甲氧基氰苯 --> 6-甲氧基-2-甲基苯并噻唑 --> 4-氨基-2,5-二氯苯酚 --> 阳离子金黄X-GL --> 3-羟基-4'-甲氧基-2-萘甲酰苯胺 --> 活性红紫X-2R --> 显色盐蓝
  • {C
  • 海关编码:292222
  • Sigma Aldrich:104-94-9(sigmaaldrich)
  • 用途三:该品主要用于染料工业,制取冰染染料,是枣红色基GP、蓝色盐VB、色酚AS-RL、色酚AS-SG、C
  • 类别:有毒物品

系列性分类