Boron trifluoride etherate 三氟化硼乙醚

CAS 109-63-7 MFCD00013194

化学结构图

109-63-7
SMILES: CC[O+](CC)[B-](F)(F)F

化学属性

Mol. FormulaBF3.C4H10O
Mol. Weight68
Density1.15
Refractive index1.3430 to 1.3470
Vapor Density4.9 (vs air)
Boiling Point124°C
Vapor Pressure4.2 mmHg ( 20 °C)
Melting Point-58
Flash Point47°(116°F)
TSCAYes
Solubility起反应
Stability对空气敏感,易吸潮
Appearance liquid 无色发烟液体。

别名和识别编码

Chemical NameBoron trifluoride etherate
MDL NumberMFCD00013194
CAS Number109-63-7
Synonym Boron fluoride (BF3), compd. wi Ethyl ether, compd. with boron fluoride (BF3) (1:1) 三氟化硼乙醚 BORON TRIFLUORIDE-DIETHYL ETHER 三氟化硼 BF3 ETHERA boron fluoride(bf3),compd. with ethyl ether(1:1) 1’-oxybis[ethane]]-trifluoro[(beta-4)-boro ethane, 1,1'-oxybis-, compd. with trifluoroborane(1:1) Boron fluoride-ethyl ether complex BORON TRIFLUORIDE DIETHYL ETHER COMPLEX (Diethyl ether)trifluoroboron Boron fluoride diethyl etherate borane,trifluoro-,cmpdwith1,1’-oxybis(ethane)(1:1) Boron fluoride etherate Diethyl ether trifluoroborane 二氟化硼乙醚 C4H10BF3O 醚合三氟化 b Boron trifluoride-ethyl ether complex BOR
EC Number 203-689-8
Beilstein Registry Number3909607
Merck Number1350
PubChem Substance ID8000
Reaxys-RN3909607
Chemical Name Translation三氟化硼乙醚
LabNetwork Molecule IDLN01313861
InChIInChI=1S/C4H10O.BF3/c1-3-5-4-2;2-1(3)4/h3-4H2,1-2H3;
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分类

  • {uni_hamburg} no charge; ether; 2fragments
  • {SNA} 25mL Sure/Seal Reagents, Boron, Catalysis and Inorganic Chemistry, Chemical Synthesis, Lewis Acids, Organometallic Reagents, Synthetic Reagents
  • {SNA}
  • {SNA} 25mL Sure/Seal Reagents, Boron, Chemical Synthesis, Essential Chemicals, Inorganic Salts, Solutions and Reagents,
  • {SNA} 25mL Sure/Seal Reagents, Acids, Acids & Bases, Boron, Catalysis and Inorganic Chemistry, Chemical Synthesis, Lewis Acids,
  • {SNA} Acids, Acids & Bases, Boron, Catalysis and Inorganic Chemistry, Chemical Synthesis, Lewis Acids, Synthetic Reagents

产品应用

  • 常用作由芳基环丙酮通过 [3+2] 环加成反应制备环戊基和环庚基[b]吲哚的催化剂。

相关文献及参考

  • Reaction with Sodium borohydride, 35788, can be used for the in situ generation of diborane. For use in the hydroboration of ɑ-pinene, see: Org. Synth. Coll., 6, 943 (1988).
  • Lewis acid catalyst in a wide variety of applications, for example:
  • Mild dehydration of tertiary alcohols to alkenes: Tetrahedron Lett., 32, 6489 (1991). In the Diels-Alder reaction: J. Am. Chem. Soc., 99, 8116 (1977). In THP protection of alcohols: Synthesis, 81, (1972).
  • Short: IV/20A
  • Reaction with ortho esters gives high yields of crystalline dialkoxycarbenium salts, useful as powerful and selective alkylating agents, (compare Triethyl­oxonium tetrafluoroborate, A14420 and Trimethyl­oxonium tetrafluoroborate, A15175): Synth. Commun., 19, 2307 (1989).
  • For use in the cleavage of ethers, see Tetra-n-butyl­ammonium iodide, A15484.
  • Catalyst for rearrangement of epoxides to carbonyl compounds, e.g. stilbene oxide to diphenylacetaldehyde and ring-contraction of isophorone oxide: Org. Synth. Coll., 4, 375 and 957 (1963), respectively.
  • Short: EINECS
  • Short: IV/20B
  • Merck:14,1350
  • Short: III/35A
  • Merck:14,1350 Beilstein: 1,IV,1321
  • Has also been used in conjunction with BMS in the reduction of amides: J. Org. Chem., 47, 3153 (1982).
  • For analogous 1,4-addition to p-benzoquinones, see 2,3-Dimethoxy-5-methyl-1,4-benzoquinone, B24777.
  • Catalyst for the reaction of allyltin reagents with aldehydes and ketones. Addition to the carbonyl group proceeds with allylic rearrangement: Chem. Lett., 919, 977 (1979); Acc. Chem. Res., 20, 243 (1987):

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H330 Fatal if inhaled 吸入致命
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+P340+P310
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P370+P378
  • P305+P351+P338+P310
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P301+P330+P331+P310
  • P303+P361+P353
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P403+P235
  • P241+P242+P243
  • P303+P361+P353+P310+P363
  • P405 Store locked up. 上锁保管。
  • P233 Keep container tightly closed. ?保持容器密闭。
Signal word
Packing GroupI
UN Number 2604
Risk Statements
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S8 Keep container dry 保持容器干燥;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
Storage condition Moisture Sensitive 充氩2-8°C避光保存。 除湿,充氩2-8°C避光保存。 2-8°C 储存温度2-8℃,充氩保存
Hazard Codes T
Hazard Class8/3
Warnings 危化品目录(2015)

其他信息

  • 在湿空气中立即水解冒烟。在光的作用下,逐渐变色。易燃。有毒。有腐蚀性,能腐蚀织物,对皮肤有刺激性。分解产生的氟化物烟雾有毒。
  • 上游原料:乙醚 --> 硫酸 --> 发烟硫酸 --> 氢氟酸 --> 硼酸 --> 氟化钙 --> 萤石粉
  • MOL 文件:109-63-7.mol
  • 图谱信息:三氟化硼乙醚(109-63-7)质谱(MS) 三氟化硼乙醚(109-63-7)红外图谱(IR1)
  • 参考质量标准:参考标准 指标名称 指标 三氟化硼(BF3)/% 46.8~47.8 水(H2O)/%≤ 0.5
  • 方法一:吸收法将硼酸与发烟硫酸和萤石粉一起加热进行反应,生成三氟化硼气体,再用乙醚吸收,减压精馏,制得三氟化硼乙醚络合物成品。其 3H2SO4+2H33BO3
  • Sigma Aldrich:109-63-7(sigmaaldrich)
  • F:10
  • 用途五:用作有机合成催化剂(乙酰化、烷基化、聚合、脱水和缩合反应的催化剂)及分析试剂。
  • 爆炸物危险
  • TCI Shanghai:三氟化硼乙醚复合物 Boron Trifluoride - Ethyl Ether Complex,>;98.0%(W)(109-63-7)
  • color:brown
  • Alfa Aesar:三氟化硼乙醚,98+% Boron trifluoride diethyl etherate, 98+%(109-63-7)
  • 可燃性危险特性:易燃; 与水或水蒸汽反应生成有毒,腐蚀性,可燃气体
  • 三氟化硼乙醚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80018728 三氟化硼乙醚 500ml 52元 2011/08/23 30236280 三氟乙基醚络合物 250ml 209.4元 2011/0
  • 方法二:将硫酸、氟化钙(萤石粉)、硼酸共热产生的三氟化硼气体,与乙醚反应,得到的三氟化硼-乙醚粗制品精制即为成品。原料消耗定额:硼酸(≥98%) 560kg/t、氟化钙(≥90%)1150kg/t、发烟硫酸(104.5%)4100kg/t、乙醚(≥99%)725kg/t。
  • 毒性:参见三氟化硼。
  • Acros Organics:三氟化硼乙醚溶液 Boron trifluoride etherate, ca. 48% BF3(109-63-7)
  • 用途三:用作有机合成中烃化和缩合反应等的催化剂(如顺丁橡胶、聚甲醛、古马隆、合成树脂等),
  • TSCA:Yes
  • 下游产品:佛手苷内酯 --> 4,5,6,7-四氢-2-甲基呋喃[2,3-C]并吡啶 --> 1-(4-(吡咯烷-1-基)丁基)肼 --> 3-羟甲基氮杂环丁烷-1-羧酸叔丁酯 --> 1-(4-吗啉基丁基)肼 --> 1-(3-(吡咯烷-1-基)丙基)肼 --> 4-硝基苯-Β-D-吡喃葡萄糖苷 --> 3,4-二羟基苯乙醇 --> 4-硝基苯基-D-吡喃葡糖苷 --> 2-溴-5-羟基吡啶 --> 溴甲基环丁烷 --> 2-溴吡啶-4-甲醛 --> 2-吗啉异烟酰醛 --> 2,5-二甲基1,3-唑-4-羰基 氯 --> (2-吗啉基吡啶-4-基)甲醇 --> 2-氟-5-羟基苯甲 酸 --> 2-氯-5-碘-3-甲基吡啶 --> 3-环戊烯-1-醇 --> 3,3-二苯基四氢呋喃-2-亚基二甲基溴化胺 --> 2-乙酰-3-甲基苯并[B]噻吩 --> 2-乙氧基-1-乙氧碳酰基-1,2-二氢喹啉 --> 2-甲基-1,3-二噻烷 --> 正丁基缩水甘油醚 --> 5-溴-7-氮杂吲哚 --> 2-(三氟乙酰基)噻吩 --> 2-(2-萘基)-1H-吲哚-3-甲醛 --> 叔丁基缩水甘油基醚 --> 2-乙酰-3-甲基噻吩
  • 类别:腐蚀物品
  • 用途四:用作有机合成乙酰化、烷基化、聚
  • 储运特性:库房通风低温干燥; 防水; 不可久存
  • 方法一:吸收法将硼酸与

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