Diethylamine 二乙胺

CAS 109-89-7 MFCD00009032

化学结构图

109-89-7
SMILES: CCNCC

化学属性

Mol. FormulaC4H11N
Mol. Weight73
Refractive indexn20/D 1.385(lit.)
Density0.707
Autoignition Point594 °F
Vapor Density2.5 (vs air)
Boiling Point55
Vapor Pressure14.14 psi ( 55 °C)
Melting Point-50
Flash Point-17°C(lit.)
TSCAYes
Solubility溶于水、醇、醚。
Stability对空气敏感

别名和识别编码

Chemical NameDiethylamine
MDL NumberMFCD00009032
CAS Number109-89-7
Synonym 氨基二乙胺 N-Ethylethanamine; N,N-Diethylamine; DEA N,N-Diethylamine Dwuetyloamina ethanamine,n-ethyl diethylamine C4H11N (diethylamine) DEA N,N-Diethylamin n-ethyl-ethanamin Diaethylamin (C2H5)2NH 二乙胺 N-Ethylethanamine Ethanamine, N-ethyl- Dietilamina N-乙基乙胺 Diethyl-amine 氨基二乙烷,N-乙基乙胺 二乙基胺 Diethamine DIISOPROPYLAMINE, >=99.5% Diäthylamin ai3-24215 Diethyl amine N-ETHYLETHANAMINE DIETHYLAMINE N-Ethylethanemine DEN N-Ethylethylamin Diethylamine N,N'-
Beilstein Registry Number605268
EC Number203-716-3
PubChem Substance ID8021
Merck Number3111
Reaxys-RN605268
Chemical Name Translation二乙胺
Wiswesser Line Notation2M2
LabNetwork Molecule IDLN00194205
InChIInChI=1S/C4H11N/c1-3-5-4-2/h5H,3-4H2,1-2H3
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分类

  • {SNA} Hordeum vulgare (Barley), Humulus lupulus (Hops), Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
  • {SNA} Analytical Reagents for General Use, C-D, Puriss p.a., Puriss p.a., 分析/色谱, 分析试剂
  • {uni_hamburg} no charge; 1fragment
  • {SA} Chemical Synthesis, Organic Bases, Synthetic Reagents
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 有机磷类杀虫剂
  • {SNA

产品应用

  • 检定锑、铂和锡,测定二硫化碳和镁,有机合成。
  • 二乙胺为溶剂和化工原料中间体,可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药,也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂(硫氮9号);纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。

相关文献及参考

  • In combination with Lithium aluminum hydride, A18116, generates lithium tris(diethylamino)aluminum hydride, which is a useful selective reducing agent, for example: esters to aldehydes: J. Org. Chem., 52, 5486 (1987); amides to aldehydes: Tetrahedron Lett., 32, 6903 (1991).
  • Merck:14,3111
  • Short: II/27B
  • Merck:14,3111 Beilstein:4,95
  • Short: II/25C
  • Alkali metal diethylamides, generated with n-BuLi or NaH, have been used for the cleavage of ethers: J. Organomet. Chem., 55, 41 (1973); Synthesis, 638 (1980), and of alkyl aryl sulfides, for which HBr and HI are usually poor: Synthesis, 583 (1982).

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302+H332
  • H332 Harmful if inhaled 吸入有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302 Harmful if swallowed 吞食有害
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US)
RTECSHZ8750000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P305+P351
  • P305+P351+P338
  • P308+P311
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Packing GroupII
UN Number 1154
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R35 Causes severe burns 会导致严重灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S29 Do not empty into drains 不要排入下水道;
  • S3 Keep in a cool place 保存在阴凉处;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Storage condition 密封阴凉保存。 Store at RT Air Sensitive
Hazard Codes 3 F,C
Hazard Class3/8
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 820 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 4,119,1951

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 5000 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
   Toxicology of New Industrial Chemical Substances.  For English translation,
   see TNICS*.  (Izdatel'stvo Meditsina, Moscow, USSR)  No.1-    1961-
   Volume(issue)/page/year: 14,80,1975

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 20 gm/m3
TOXIC EFFECTS :
   Sense Organs and Special Senses (Olfaction) - effect, not otherwise
   specified
   Lungs, Thorax, or Respiration - emphysema
   Liver - fatty liver degeneration
REFERENCE :
   12OVAW "Voprosy Promyshlennoi Toksikologii," Pravdin, N.S., ed., Akademiya
   Meditsinskikh Nauk-SSSR, Moscos, Russia, 1960  Volume(issue)/page/year:
   -,176,1960

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4000 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEHLAU Archives of Environmental Health

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 400 uL/plate
REFERENCE :
   EJMBA2 Egyptian Journal of Microbiology.  (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.7-
   1972-  Volume(issue)/page/year: 15,113,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 uL/plate
REFERENCE :
   EJMBA2 Egyptian Journal of Microbiology.  (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.7-
   1972-  Volume(issue)/page/year: 15,113,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 50 uL/plate
REFERENCE :
   EJMBA2 Egyptian Journal of Microbiology.  (National Information and
   Documentation Centre, A1-Tahrir St., Awqaf P.O. Dokki, Cairo, Egypt)  V.7-
   1972-  Volume(issue)/page/year: 16,133,1981

Restrict 危险品

其他信息

  • 急性毒性:口服- 大鼠 LD50: 540 毫克/ 公斤; 口服- 小鼠 LD50: 500 毫克/ 公斤
  • 下游产品:孟鲁司特 --> 4-碘代苯乙酮 --> 4,6-二甲基-3-氨基吡唑并[3,4-B]吡啶 --> 2-氨基-6-甲基-4,5,6,7-四氢-1-苯并噻吩-3-腈 --> 2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲腈 --> 1,4,6-三甲基-3-氨基吡唑并[3,4-B]吡啶 --> 乐可安 --> N,N-二乙基氯甲酰胺 --> 肉桂酸苄酯 --> 2-氨基-3-腈基-4,5,6,7--四氢苯并[B]噻吩 --> 2-氨基-3-腈基-4,5-二甲基噻吩 --> 柳酸苄酯 --> 5-氨基-3-甲基噻吩-2,4-二甲酸二甲酯 --> 3-氰基-4,6-二甲基-2-羟基吡啶 --> 1-二乙胺基甲酰基-4-甲基哌嗪 --> 红色基 ITR --> 2-(N,N-二乙基甲酰氨)苯基硼酸 --> 二乙基二硫代氨基甲酸锌 --> 酚磺乙胺 --> 2-氯-3-氰基-4,6-二甲基吡啶 --> 盐酸利多卡因 --> 1,1-二乙基胍盐酸盐 --> N,N-二乙基氰乙酰胺 --> 盐酸普鲁卡因 --> 双(二乙胺基)氯磷 --> 二乙胺盐酸盐 --> N-氰基二乙基胺 --> S-2-(4-氯苯基)-3-甲基丁酸 --> 桃红色基ITR --> 3-二乙胺基丙胺 --> 铁锚102涂层胶 --> 避蚊胺 --> N,N-二乙基烟酰胺 --> 二硫化四乙基秋兰姆 --> 二乙基二硫代氨基甲酸二乙铵盐 --> N,N-二乙基-2-氯丙酰胺 --> 六乙基亚磷酸胺
  • 用途五:检定锑、铂和锡,测定二硫化碳和镁,有机合成。二乙胺为溶剂和化工原料中间体,可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药,也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂(硫氮9号);纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。
  • 防护措施:本品为毒、腐蚀性易燃品。其蒸气或液体均对眼睛、皮肤和呼吸道粘膜有刺激和腐蚀作用,引起搔痒、红肿,严重时,会造成损伤。大量接触会穿透组织引起深度坏死。鼠类经口LD50为540mg/kg。生产现场最高容许浓度75mg/m3。生产设备应密闭。操作人员应戴防毒口罩、胶乳手套、橡胶围裙和眼镜等防护用品。溅及皮肤时,应用清水冲洗,以2%的醋酸、柠檬酸或硼酸溶液湿敷。如眼睛溅入二乙胺,要立即张开双眼,用水进行彻底冲洗,滴入2%的普鲁卡因或含有0.1%肾上腺素的0.5%的普鲁卡因溶液,随后涂擦消过毒的凡士林或橄榄油。戴上防护眼镜,请眼科医生诊治。
  • MOL 文件:109-89-7.mol
  • 毒性分级:高毒
  • F:10-23
  • Sigma Aldrich:109-89-7(sigmaaldrich)
  • 敏感性:Air Sensitive
  • 蒸气压:14.14 psi ( 55 °C)
  • 用途四:二乙胺为溶剂和化工原料中间体,可制取药物普鲁卡因、氯喹、尼可刹米、可拉明及磺胺等类药,也可用于生产农药、染料、橡胶硫化促进剂、选矿药剂(硫氮9号)、纺织助剂、杀菌剂、缓蚀剂、阻聚剂和抗冻剂等。需消耗二乙胺的医药产品及其二乙胺的消耗量:头孢唑啉钠0.789kg/kg、头孢拉啶0.059kg/kg、合成黄连素0.030kg/kg、磺胺嘧啶0.150kg/kg、磷酸氯喹0.340kg/kg、咳必清0.710kg/kg、灭吐灵0.960kg/kg、止血敏0.660kg/kg、盐酸普鲁卡因0.600kg/kg、盐酸利多卡因0.890kg/kg。
  • TCI Shanghai:二乙胺 Diethylamine,>;99.0%(GC)(109-89-7)
  • Alfa Aesar:二乙胺,99% Diethylamine, 99+%(109-89-7)
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 有强烈氨臭,强碱性,呈碱性反应。能与水、乙醇和乙醚等有机溶剂混溶。
  • 灭火剂:干粉、雾状水、二氧化碳、泡沫
  • 用途一:用作医药、
  • 用途二:用作分析试剂和防腐剂,也用于有机合成及染料的制造
  • 爆炸物

系列性分类