Ethyl formate 甲酸乙酯

CAS 109-94-4 MFCD00003294

化学结构图

109-94-4
SMILES: CCOC=O

化学属性

Autoignition Point851 °F
Refractive index1.3590 to 1.3630
Vapor Density2.5 (vs air)
Boiling Point52-54
Vapor Pressure15.16 psi ( 55 °C)
Melting Point-80
Flash Point-20°C(lit.)
TSCAYes
SolubilitySoluble in water (105 g/l at 20 °C).
Stability对湿度敏感
Density0.921
Mol. FormulaC3H6O2
Mol. Weight74.00

别名和识别编码

Chemical NameEthyl formate
CAS Number109-94-4
EC Number203-721-0
Beilstein Registry Number906769
MDL NumberMFCD00003294
Synonym Aethylformiat Ameisensäure-ethylester Areginal C3H6O2 (formic acid ethyl ester) Ethyl formate Ethyl methanoate Ethyl methanoate 蚁酸乙酯 Ethyl methanoate; Formic acid ethyl ester Ethyle (formiate d') Ethylester kyseliny mravenci Ethylformiaat Ethylformiat Etile (formiato di) Formic acid ethyl ester Formic acid, ethyl ester Formic ether Mrowczan etylu ethyl formate formic acid ethyl ester Äthylformiat 甲酸乙酯 蚁酸乙酯
PubChem Substance ID8025
Merck Number3807
Reaxys-RN906769
Chemical Name Translation甲酸乙酯
Wiswesser Line NotationVHO2
LabNetwork Molecule IDLN00163927
InChIInChI=1S/C3H6O2/c1-2-5-3-4/h3H,2H2,1H3
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分类

  • {SNA} Ethyl Ester,
  • {SNA} A-F, Alcoholic & Nonalcoholic Beverages, All Alphabetically Sorted, Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Animal Products, Beer, Brandy & Cognac, Butter, Cabbage, Chemical Class, Chromatography, Dairy Products, E, E-L,
  • {SNA} Ethyl Ester, Fatty Acyls, Fatty Esters, 生化试剂, 脂类
  • {SNA} Alphabetical Listings, Certified Food Grade Products, E-F, E-G, E-H,
  • {SNA} Alphabetical Listings,
  • {SNA} Alphabetical Listings,

产品应用

  • 有机溶剂,有机合成,制酒香料。医药工业原料。

相关文献及参考

  • Merck:14,3807
  • Many illustrations of use in formylation of carbanions are given in Organic Syntheses: For more recent examples, see: Org. Synth. Coll., 6, 590, Note 1 (1988); Org. Synth. Coll., 9, 180 (Note 4), 239, 548 (1998).
  • ɑ-Formylation of the dilithio derivatives of carboxylic acids, followed by facile decarboxylation, provides an indirect conversion to the corresponding aldehydes: Tetrahedron Lett., 699 (1970); 603 (1974).
  • Short: II/19b
  • Short: II/14a
  • Amines readily give N-formyl derivatives, more easily cleaved by hydrolysis than N-acetyl: Can. J. Chem., 60, 3055 (1982); for an example (L-valinol), see: Org. Synth. Coll., 8, 204 (1993).
  • Short: II/25C
  • Merck:14,3807 Beilstein: 2,IV,23

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S24 Avoid contact with skin 避免皮肤接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P301+P317
  • P303+P361+P353
  • P304+P312
  • P304+P317
  • P304+P340
  • P304+P340+P312
  • P305+P351+P338
  • P305+P351+P338+
  • P307+P311
  • P308+P316
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P337+P313
  • P337+P317
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H302+H332
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)
RTECSLQ8400000
Packing GroupII
UN Number 1190
Hazard Codes 3
Storage condition 密封干燥保存。
Hazard Class3
Warnings 危化品目录(2015)
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 gm/kg/9W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   9,177,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 1110 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - gastritis
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 16,737,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2075 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IMSUAI Industrial Medicine and Surgery.  (Northbrook, IL)  V.18-42, 1949-73.
    For publisher information, see IOHSA5.  Volume(issue)/page/year: 41,31,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >20 mL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 10,61,1954

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
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Restrict 危险品

其他信息

  • 有令人愉快的气味。不稳定,易水解。有吸湿性。能与醇和和醚混溶,能溶于10份水,同时逐渐分解出甲酸及乙醇,能刺激皮肤和粘膜,浓度高时有麻醉性。
  • 有令人愉快的气味。不稳定,易水解。有吸湿性。能与醇和和醚混溶,能溶于13份水,同时逐渐分解出甲酸及乙醇,能刺激皮肤和粘膜,浓度高时有麻醉性。
  • 有令人愉快的气味。不稳定,易水解。有吸湿性。能与醇和和醚混溶,能溶于12份水,同时逐渐分解出甲酸及乙醇,能刺激皮肤和粘膜,浓度高时有麻醉性。
  • 有令人愉快的气味。不稳定,易水解。有吸湿性。能与醇和和醚混溶,能溶于15份水,同时逐渐分解出甲酸及乙醇,能刺激皮肤和粘膜,浓度高时有麻醉性。
  • 有令人愉快的气味。不稳定,易水解。有吸湿性。能与醇和和醚混溶,能溶于11份水,同时逐渐分解出甲酸及乙醇,能刺激皮肤和粘膜,浓度高时有麻醉性。

系列性分类