Trifluoromethanesulfonic acid 三氟甲磺酸

CAS 1493-13-6 MFCD00007514

化学结构图

1493-13-6
SMILES: O=S(=O)(O)C(F)(F)F

化学属性

Refractive index1.3260 to 1.3310
SolubilitySoluble in water, DMSO, DMF, and acetonitrile.
TSCAYes
Flash PointNone
Melting Point-40
Vapor Density5.2 (vs air)
Vapor Pressure8 mmHg ( 25 °C)
Mol. FormulaCHF3O3S
Mol. Weight150
Density1.69
Appearance colorless to light brown fuming liq.
Stabilityhygroscopic
Boiling Point162

别名和识别编码

PubChem Substance ID62406
Beilstein Registry Number3(4)34
Reaxys-RN1812100
Merck Number9676
Synonym FC-24 Fluorad FC 24 TFMSA TRIFLIC ACID TRIFLUOROMETHANESULFONIC ACID TRIFLUOROMETHANESULFONIC ACID, REAGENTPLUS, >=99% TRIFLUOROMETHYLSULFONIC ACID TRIMESYLATE ACID Triflate Triflic acid, Triflate Triflic acid;Triflate Triflicacid Trifluoromethanesulfonnic acid Trifluoromethanesulphonic acid/Triflic acid perfluoromethanesulfonic acid trifluormethansulfonsäure trifluoro-methanesulfonic acid trifluoro-methanesulfonicaci trifluoromethane-sulfonic acid trifluoromethanesulfonic trifluoromethanesulfonic acid trifluoromethylsulfonic acid 三氟甲基磺酸 三氟甲烷磺酸 三氟甲烷磺酸, 98+% 三氟甲磺酸;全氟甲磺酸;三氟利克酸;三氟甲基磺酸
EC Number216-087-5
LabNetwork Molecule IDLN00007166
Chemical NameTrifluoromethanesulfonic acid
Chemical Name Translation三氟甲磺酸
InChIInChI=1S/CHF3O3S/c2-1(3,4)8(5,6)7/h(H,5,6,7)
MDL NumberMFCD00007514
CAS Number1493-13-6
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分类

  • Acid Solutions, Analytical Reagents, Analytical/Chromatography, By Reference Material, Chemical Synthesis, Non-aqueous Titration Reagents, Organic Acids, Reference Material Potassium hydrogen
  • {SNA} Acid Solutions, Acids, Acids & Bases, By Reference Material, Chemical Synthesis,

产品应用

  • 异构化和烷基化的催化剂。制备2,3-二氢-2-茚酮、四氢萘酮。去除糖蛋白中糖苷。

相关文献及参考

  • Adds to both internal and terminal alkynes to give vinyl triflates: J. Am. Chem. Soc., 91, 4600 (1969); Org. Synth. Coll., 9, 472 (1998). Reaction in the presence of a nitrile provides a route to sterically hindered 2,4,6-trisubstituted pyrimidines: Synthesis, 881 (1990):
  • Short: II/25B
  • One of the strongest available monoprotic acids. For a review of the chemistry of triflic acid and its derivatives, see: Chem. Rev., 77, 69 (1977).
  • Merck:9676 Beilstein:3(4)34
  • Simple triflic esters, readily prepared by reaction with alcohols, are powerful alkylating agents and must be handled with extreme care because of their irritating effect on the lungs. For a review, see: Synthesis, 85 (1982).
  • For use in direct electrophilic amination of arenes, see Trimethyl­silyl­ azide, L00173. Effects direct oxy-functionalization of aromatics in combination with bis(TMS) peroxide: J. Org. Chem., 54, 1204 (1989); or sodium perborate: Synlett, 39 (1991).
  • Merck:9676

安全信息

GHS Symbol
WGK Germany2
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H302+H312
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 8 C
Precautionary statements
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P330+P331
  • P301+P330+P331+P310
  • P303+P361+P353+P310+P363
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 3265 UN 3265 8/PG 2 UN3265
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R10 Flammable 易燃
  • R20/22 Harmful by inhalation and if swallowed 吸入和不慎吞咽有害
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R35 Causes severe burns 会导致严重灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition -20°C Hygroscopic 储存温度2-8℃ ,充氩保存 储存温度2-8℃ 密封阴凉干燥保存。
RTECSPB2771000
Packing GroupII
Hazard Class8

其他信息

  • color:slightly brown
  • 用途一:用于有机合成
  • MOL 文件:1493-13-6.mol
  • 下游产品:三氟甲磺酸酐 --> 2,2-双(4-羧基苯基)六氟丙烷 --> 4-硝基喹啉-N-氧化物 --> 4-溴-7-氮杂吲哚 --> 三氟甲烷磺酸甲酯 --> C10-18 脂酸甘油三酯类 --> 叔丁基二甲硅基三氟甲磺酸酯 --> 三氟甲磺酸二丁硼 --> 2,6-二叔丁基-4-甲基吡啶 --> 三氟甲烷磺酸锌 --> 三氟甲烷磺酸镧 --> 三氟甲烷磺酸酮
  • Acros Organics:三氟甲磺酸 Trifluoromethanesulfonic acid, extra pure, 99%(1493-13-6)
  • F:3-10
  • 三氟甲磺酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 C169890500 三氟甲烷磺酸 50ml 983元 2011/08/23 LA1017301 三氟甲烷磺酸 10g 218元 2011/08/23 L0670601 三氟甲烷磺酸, 10g 218元
  • 湿空气中发烟,易吸湿形成一水合物。强酸性。与水混溶,溶于多数极性有机溶剂,如二甲基亚砜、二甲基砜。有腐蚀性。
  • 用途二:异构化和烷基化的催化剂。制备2,3-二氢-2-茚酮、四氢萘酮。去除糖蛋白中糖苷。
  • TCI Shanghai:三氟甲磺酸 Trifluoromethanesulfonic Acid,>;98.0%(T)(1493-13-6)
  • Hazard Note:Corrosive/Hygroscopic
  • MSDS 信息:Trifluoromethanesulfonic acid(1493-13-6).msds
  • Alfa Aesar:三氟甲烷磺酸,98+% Trifluoromethanesulfonic acid, 98+%(1493-13-6)
  • 蒸气压:8 mm Hg ( 25 °C)
  • Sigma Aldrich:1493-13-6(sigmaaldrich)
  • 图谱信息:三氟甲磺酸(1493-13-6)红外图谱(IR1)
  • 蒸气密度:5.2 (vs air)
  • 存储注意事项:惰性气体保护
  • 制备方法:黄棕色液体。沸点167~170℃。折射率1.331。相对密度1.708。为最强的有机酸,极易溶于水。 以二硫化碳为原料,与五氟化碘反应生成三氟甲基二硫化物。与汞反应得三氟甲硫基汞(CF3S)2Hg,后者经过氧化氢氧化即得三氟甲磺酸。
  • 海关编码:29049020
  • 敏感性:Hygroscopic

系列性分类