2-(2-Amino-3-Methoxyphenyl)-4H-Chromen-4-One 2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮
CAS 167869-21-8 MFCD00671789
化学结构图
SMILES: COc1cccc(-c2cc(=O)c3ccccc3o2)c1N
化学属性
| Mol. Formula | C16H13NO3 |
|---|---|
| Mol. Weight | 267.28 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 2-(2-Amino-3-Methoxyphenyl)-4H-Chromen-4-One |
|---|---|
| Synonym | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one PD98059 PD98059; PD-98059; PD 98059; PD098059 |
| MDL Number | MFCD00671789 |
| PubChem Substance ID | 24278666 |
| CAS Number | 167869-21-8 |
| Chemical Name Translation | 2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮 |
| LabNetwork Molecule ID | LN00001912 |
| Formula | C16H13NO3 |
| IUPAC Name | 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one |
| InChIKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
| InChI | InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3 |
| Canonical SMILES | O=C1C=C(C2=CC=CC(OC)=C2N)OC3=C1C=CC=C3 |
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分类
- {SA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Mitogen-Activated Protein Kinase Kinase (MAPKK), P, Phosphorylation Analysis, Post-Translational Modification, Protein Kinase Inhibitors, Proteomics, Se
- {SNA} Bioactive Small Molecule Alphabetical Index, Kinase/Phosphatase Biology, Mitogen-Activated Protein Kinase Kinase (MAPKK), P-PH, Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 分子生物学, 生物活性小分子, 磷酸化分析, 细胞信号转导和神经科学, 细胞生物学, 翻译
产品应用
- PD98059 also known as PD-98059, is a potent and selective inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). It mediates its inhibitory properties by binding to the ERK-specific MAP kinase MEK, therefore preventing phosphorylation of ERK1/2 (p44/p42 MAPK) by MEK1/2. MAPK ERK1/2 is involved in TLR-induced production of cytokines.
相关文献及参考
- Alessi, et al., PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 270 , 27489-27494, (1995) 摘要
- Dudley, et al., A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl. Acad. Sci. U. S. A. 92 , 7686, (1995) 摘要
- Pang, et al., Inhibition of MAP kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270 , 13585-13588, (1995) 摘要
- Hamazaki T, Kehoe SM, Nakano T, Terada N, The Grb2/Mek pathway represses Nanog in murine embryonic stem cells. Mol. Cell. Biol. , 7539-49, (1995)
- Chen X, et. al., Dedifferentiation of adult human myoblasts induced by ciliary neurotrophic factor in vitro. Mol. Biol. Cell , 3140-51, (2005) 摘要
- Perales M, Mas P, A functional link between rhythmic changes in chromatin structure and the Arabidopsis biological clock. Plant Cell , 2111-23, (2005)
- Brown SE, Szyf M, Epigenetic programming of the rRNA promoter by MBD3. Mol. Cell. Biol. , 4938-52, (2007) 摘要
- Yan J, Gao Z, Yu G, He Q, Weng J, Ye J, Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha. Mol. Endocrinol. , 1630-41, (2007) 摘要
安全信息
GHS Symbol
- P301+P310
- H301 Toxic if swallowed 吞食有毒
- R22 Harmful if swallowed 吞咽有害
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