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分类

• {SNA} Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Protection and Derivatization, Synthetic Reagents
• {SNA} Chemical Synthesis, Deprotecting Reagents, Fluoride Sources, Other Supported Reagents, Protection and Derivatization, Solid Supported Synthesis, Specialty Synthesis, Supported Reagent

产品应用

• 用于酰基化,硅化反应和硅醚解理的催化剂

相关文献及参考

• Fluoride ion as a base in organic synthesis: Chem. Rev., 80, 429 (1980). Synthetic aspects of the use of organosilicon compounds under nucleophilic catalysis conditions: Tetrahedron, 44, 2675 (1988). For a brief feature on uses of TBAF, see: Syn
• For the cleavage of disilanes to give "metal-free" silyl anions, see Hexamethyl­disilane, A13155.
• Merck: 14,9187
• For nucleophilic displacement of halide or tosylate by TBAF in the preparation of alkyl and acyl fluorides, see: J. Org. Chem., 49, 3216 (1984); Org. Synth. Coll., 8, 258 (1993).
• Mild catalyst for the silylation of OH by silazanes: Tetrahedron Lett., 35, 8409 (1994), or by hydrosilanes and disilanes: Tetrahedron Lett., 35, 8413 (1994). See Appendix 4.
• Ester enolates can be displaced from silicon, and trapped by reaction with carbonyl compounds without ɑ-hydrogens: Tetrahedron Lett., 1699 (1976). Under similar conditions, ketones with ɑ-hydrogens are converted under kinetic control to their silyl enol ethers with high (Z)-stereoselectivity (see Ethyl­ (trimethyl­silyl)­acetate, A17707): J. Am. Chem. Soc., 98, 2346 (1976); Org. Synth. Coll., 7, 512 (1990):
• Reagent for deprotection of N-Boc groups under mild conditions: Tetrahedron Lett., 43, 589 (2002).
• Promotes the directed aldol condensation of silyl enol ethers with aldehydes at low temperatures under very mild conditions: J. Org. Chem., 48, 932 (1983); alkali metal fluorides give poor results.
• Many other examples exist where the reagent acts as a base in organic synthesis:
• Specific reagent for the cleavage of silyl ethers, including TBDMS: J. Am. Chem. Soc., 94, 6190 (1972), (see tert-Butyl­dimethyl­chlorosilane, A13064), as well as the more stable TBDPS: Org. Synth. Coll., 9, 4 (1998), and TIPS: J. Org. Chem., 45, 4797 (1980); (see also tert-Butyl­diphenyl­chlorosilane, A12721 and Chlorotriisopropyl­silane, A17376).
• Reviews:

安全信息

GHS Symbol

其他信息

• MOL 文件:22206-57-1.mol
• 四丁基氟化铵水合物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T1037 四丁基氟化铵水合物[用于酰基化,硅化反应和硅醚解理的催化剂] Tetrabutylammonium Fluoride Hydrate [for Catalyst of acylation, silylation and cleavage of silyl ether] 25G 1350元 2011/04/16 T1037 四丁基氟化铵水合物[用于酰基化,硅化反应和硅醚解理的催化剂] Tetrabutylammonium Fluoride Hydrate [for Catalyst of acylation, silylation and cleavage of silyl ether] 250G 7680元
• F:3
• TCI Shanghai:四丁基氟化铵水合物[用于酰基化,硅化反应和硅醚解理的催化剂] Tetrabutylammonium Fluoride Hydrate [for Catalyst of acylation, silylation and cleavage of silyl ether],>;98.0%(T)(22206-57-1)
• Sigma Aldrich:22206-57-1(sigmaaldrich)