Lepidine 4-甲基喹啉

CAS 491-35-0 MFCD00006784

化学结构图

491-35-0
SMILES: Cc1ccnc2ccccc12

化学属性

Mol. FormulaC10H9N
Mol. Weight143
Density1.083
Refractive index1.6170 to 1.6210
Boiling Point261-263
Melting Point9-10
Flash Point>110°(230°F)
TSCAYes
Solubility略溶于水
Stability对光敏感

别名和识别编码

Chemical NameLepidine
CAS Number491-35-0
Alfabeta NameLEPIDINE
MDL NumberMFCD00006784
Synonym 4-Lepidine 4-METHYLCHINOLINE 4-METHYLQUINUOLINE 4-Methyl-chinolin 4-Methylchinolin 4-Methylquinoline 4-Methylquinoline, Lepidine 4-甲喹啉 4-甲基-喹啉 4-甲基喹啉 4-甲基喹啉 勒皮啶 p-Methylquinoline ?-Methylquinoline Cincholepidine LEPIDINE LEPIDINE, 99% (4-METHYLQUINOLINE) Lepidin Lepidine Lepidine,98% Quinoline, 4-methyl- Quinoline,4-methyl- gamma-Methylquinoline γ-Methylquinoline γ-甲基喹啉 勒吡啶
EC Number207-734-2
Beilstein Registry Number110926
PubChem Substance ID87571993
Merck Number5441
Chemical Name Translation4-甲基喹啉
Reaxys-RN110926
Wiswesser Line NotationT66 BNJ E1
LabNetwork Molecule IDLN00171532
InChIInChI=1S/C10H9N/c1-8-6-7-11-10-5-3-2-4-9(8)10/h2-7H,1H3
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分类

  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; 1fragment
  • {SNA} Alphabetical Listings, Flavors and Fragrances, M-N
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines

产品应用

  • 用作染料、医药、感光材料的中间体。

相关文献及参考

  • Short: II/27B
  • Lepidine and similar compounds can be alkylated at the 2-position by free radicals generated by the action of t-butyl hydroperoxide and a salt of Fe(II) on a primary or secondary alkyl iodide: Acta Chem. Scand., 43, 995 (1989). Similarly, 2-formylation can be achieved in high yield using 1,3,5-trioxane in the presence of TFA, t-BuOOH and FeSO4 in acetonitrile: J. Org. Chem., 51, 536 (1986).
  • Merck: 14,5441 Beilstein:20,395
  • Short: III/35B
  • Merck: 14,5441

安全信息

Warnings 危化品目录(2015) IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSOH0316000
Storage condition 密封避光保存 Light Sensitive
Hazard Codes Xn Xi Xi,Xn
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 42,335,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 12,217,1991

其他信息

  • 可燃性危险特性:受热分解有毒氧化氮气体
  • 检测方法:GC,NMR
  • 敏感性:Light Sensitive
  • 用途一:用作染料、医药、感光材料的中间体。
  • 灭火剂:二氧化碳、砂土、泡沫、水
  • 类别:有毒物品
  • Sigma Aldrich:491-35-0(sigmaaldrich)
  • Alfa Aesar:4-甲基喹啉,98% Lepidine, 98%(491-35-0)
  • 方法一:从煤油中回收可得到该品。重吡啶残渣油中精馏截取的260-267℃馏分段内含4-甲基喹啉35%-56%。将此馏分在酒精中与浓度为98%的浓硫酸反应,温度控制在35℃,生成磺酸盐,经冷却、结晶、过滤后,所得结晶用3倍重量的酒精重结晶,得熔点大于220℃的结晶,再用20%的深氨水在室温下分解至pH=8,得粗制4-甲基喹啉。然后在20块理论板的蒸馏塔蒸馏,切取262.3-266.8℃馏分,得纯度大于95%的4-甲基喹啉。
  • 上游原料:乙醇 --> 乙酸乙酯 --> 硫酸 --> 乙酸 --> 三氯氧磷 --> 氢氧化铵 --> 二甲苯 --> 氨基苯 --> 锌粉 --> 五氯化磷 --> 氯化锌 --> 碘 --> 红磷 --> 六水三氯化铁 --> N-乙酰乙酰苯胺 --> 丁烯酮
  • 存储注意事项:光敏感
  • 能与乙醇、乙醚、苯混溶,微溶于水,见光变成红棕色。
  • MOL 文件:491-35-0.mol
  • 图谱信息:4-甲基喹啉(491-35-0)核磁图( 13 CNMR) 4-甲基喹啉(491-35-0)质谱(MS) 4-甲基喹啉(491-35-0)红外图谱(IR1)
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 4-甲基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 A15828303 4-甲基喹啉99% 100g 3637元 2011/04/16 L0024 勒皮啶 Lepidine 25ML 759元 2011/04/16 L0024 勒皮啶 Lepidine 500ML 7880元
  • MSDS 信息:4-甲基喹啉(491-35-0).msds
  • 外观性质:无色油状液体,遇光变成红棕色。
  • TCI Shanghai:4-甲基喹啉 Lepidine,>;97.0%(GC)(491-35-0)
  • 下游产品:喹啉-4-羧酸 --> 4-喹啉甲醛 --> 8-氨基喹啉-4-羧酸甲酯
  • F:8-10
  • Acros Organics:4-甲基喹啉 Lepidine, 99%(491-35-0)

系列性分类


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