4-Hydroxyquinazoline 4-羟基喹唑啉

CAS 491-36-1 MFCD00511302

化学结构图

491-36-1
SMILES: O=c1[nH]cnc2ccccc12

化学属性

Mol. FormulaC8H6N2O
Mol. Weight146.15
Melting Point216-219
TSCANo
Appearance 本品为白色结晶,m.p.214~215℃,不溶于水。

别名和识别编码

Chemical Name4-Hydroxyquinazoline
CAS Number491-36-1
Alfabeta NameQUINAZOLINONE H43()--
MDL NumberMFCD00511302
Synonym 4(3H)-喹唑酮 4-HQN 4-Quinazolinol 4-Quinazolone 4-喹唑酮 AKOS BBS-00002691
EC Number207-735-8
Beilstein Registry Number607148
PubChem Substance ID135408753
Chemical Name Translation4-羟基喹唑啉
Reaxys-RN607148
Wiswesser Line NotationT66 BVM ENJ
LabNetwork Molecule IDLN00164643
InChIInChI=1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
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分类

  • {SNA} Bioactive Small Molecules, Building Blocks, Chemical Synthesis, H, Heterocyclic Building Blocks, Quinazolines, 细胞生物学
  • {SNA} Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, H, Heterocyclic Building Blocks, Quinazolines
  • {Chemicalbook} 农药中间体: 杀螨剂中间体
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Quinazolines

安全信息

Warnings IRRITANT
RTECSVA2300000
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xi Xi,Xn
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,1204,1962

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 609 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,1204,1962

其他信息

  • 方法二:由邻氨基苯甲酸与甲酰胺环合而得。将邻氨基苯甲酸和甲胺加入不锈钢反应锅内,搅拌加热4h,油浴温度140-150℃。在搅拌下加入冷水,待温度降至60℃以下时,将产物加水搅拌均匀,放置过夜。过滤、水洗、醇洗,在100-120℃干燥,得喹唑酮,收率80%。
  • Sigma Aldrich:491-36-1(sigmaaldrich)
  • 用途二:该品是抗心律失常药常咯啉的中间体。
  • TCI Shanghai:4-羟基喹唑啉 4-Hydroxyquinazoline,>;98.0%(T)(491-36-1)
  • 海关编码:29335995
  • 4-羟基喹唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 H0803 4-羟基喹唑啉 4-Hydroxyquinazoline 25G 986元 2010/06/21 121880050 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 5 GR 328元 2010/06/21 121880250 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 25 GR 1297元
  • 方法一:其制备方法是在四口烧瓶中加入邻氨基苯甲酸和甲酰胺,搅拌下加热至125~130℃,反应4h得浅红色固体,重结晶得成品。
  • 4-羟基喹唑啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 H0803 4-羟基喹唑啉 4-Hydroxyquinazoline 25G 999元 2010/06/21 121880050 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 5 GR 328元 2010/06/21 121880250 4-羟基喹唑啉 4-Hydroxyquinazoline 98% 25 GR 1297元
  • Alfa Aesar:4-羟基喹唑啉,98% 4-Hydroxyquinazoline, 98%(491-36-1)
  • 图谱信息:4-羟基喹唑啉(491-36-1)核磁图( 13 CNMR) 4-羟基喹唑啉(491-36-1)质谱(MS) 4-羟基喹唑啉(491-36-1)红外图谱(IR1) 4-羟基喹唑啉(491-36-1)红外图谱(IR2)
  • Acros Organics:4-羟基喹唑啉 4-Hydroxyquinazoline, 98%(491-36-1)
  • 敏感性:Hygroscopic
  • 上游原料:邻氨基苯甲酸 --> 2-羟基喹喔啉 --> 四口烧瓶 --> 不锈钢反应锅 --> 浅红
  • 用途一:4-(3H)喹唑啉酮是杀螨剂喹螨醚的中间体。
  • 下游产品:4-氯喹唑啉
  • MOL 文件:491-36-1.mol
  • MSDS 信息:4-Hydroxyquinazoline(491-36-1).msds

系列性分类


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