N,O-Dimethylhydroxylamine Hydrochloride N,O-二甲基羟胺盐酸盐

CAS 6638-79-5 MFCD00012485

化学结构图

6638-79-5
SMILES: CNOC.Cl

化学属性

Mol. FormulaC2H8ClNO
Mol. Weight97.54
Density1.422
Melting Point112-115°C
TSCAYes
Solubility可溶
Stability易吸湿
Appearance 易溶于水,溶于乙醇。

别名和识别编码

Chemical NameN,O-Dimethylhydroxylamine Hydrochloride
CAS Number6638-79-5
Alfabeta NameDIMETHYLHYDROXYLAMINEHYDROCHLORIDE NO-,
MDL NumberMFCD00012485
Synonym N,O-Dimethylhydroxylamine (hydrochloride) {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} N,O-Dimethylhydroxylamine (hydrochloride) {} {} {} {} {} {} {}
EC Number229-642-1
Beilstein Registry Number3650353
PubChem Substance ID81138
Chemical Name TranslationN,O-二甲基羟胺盐酸盐
Reaxys-RN3650353
InChIKeyUSZLCYNVCCDPLQ-UHFFFAOYSA-N
LabNetwork Molecule IDLN00173933
InChIInChI=1S/C2H7NO.ClH/c1-3-4-2;/h3H,1-2H3;1H
Canonical SMILESCONC.[H]Cl
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分类

  • {SA} Active Esters/Additives, Chemical Synthesis, Coupling, Synthetic Reagents
  • {SNA} Active Esters/Additives, Chemical Synthesis, Coupling, Synthetic Reagents
  • {uni_hamburg} no charge; 2fragments; ionic

产品应用

  • 制备 Weinreb 酰胺的试剂,Weinreb 酰胺最近用于由 2-噁唑氯化镁合成 2-酰基噁唑。

相关文献及参考

  • Short: III/20a
  • Short: EINECS
  • Reaction with Grignard or organolithium reagents gives ketones: Tetrahedron Lett., 22, 3815 (1981). Reduction with Lithium aluminum hydride, A18116, gives the aldehyde: Synthesis, 676 (1983). For subsequent conversion of Boc-amino acid derived aldehydes and ketones to pyrrole derivatives, see: J. Org. Chem., 61, 4999 (1996). Coupling with alkyl acetoacetates gives ß δ
  • Reaction with Grignard or organolithium reagents gives ketones: Tetrahedron Lett., 22, 3815 (1981). Reduction with Lithium aluminum hydride, A18116, gives the aldehyde: Synthesis, 676 (1983). For subsequent conversion of Boc-amino acid derived aldehydes and ketones to pyrrole derivatives, see: J. Org. Chem., 61, 4999 (1996). Coupling with alkyl acetoacetates gives ß δ -diketo esters: Tetrahedron Lett., 29, 6467 (1988). For conversion to ɑ -diketones or ɑ -keto esters, see: J. Org. Chem., 54, 3913 (1989).
  • The N-methoxy-N-methylamides (Weinreb amides) of carboxylic acids, N-protected amino acids and peptides are readily prepared from the acid chloride or mixed anhydride, or from the acid in the presence of 2-Chloro-1-methyl­pyridinium iodide, A12820: Synth. Commun., 25, 1277 (1995); or BOP Reagent (1H-Benzotriazol-1-yl­oxytris(dimethyl­amino)­phosphonium hexafluorophosphate, A16140): J. Org. Chem., 61, 4999 (1996). The products undergo a number of useful transformations, e.g.:

安全信息

Warnings IRRITANT
Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Hygroscopic Store at RT. Store at room temperature {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {}
Hazard Codes Xi

其他信息

  • MOL 文件:6638-79-5.mol
  • 二甲羟胺盐酸盐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1899 N,O-二甲基羟胺盐酸盐 N,O-Dimethylhydroxylamine Hydrochloride 25G 189元 2014/06/02 D1899 N,O-二甲基羟胺盐酸盐 N,O-Dimethylhydroxylamine Hydrochloride 500G 1370元 2010/06/21 116340250 二甲羟胺盐酸盐 N,O-Dimethylhydroxylamine hydrochloride 98% 25 GR 1131元
  • 敏感性:Hygroscopic
  • 存储注意事项:湿度敏感
  • TCI Shanghai:N,O-二甲基羟胺盐酸盐 N,O-Dimethylhydroxylamine Hydrochloride,>;98.0%(T)(6638-79-5)
  • MSDS 信息:N,O-Dimethylhydroxylamine hydrochloride(6638-79-5).msds
  • 检测方法:T,NMR
  • Alfa Aesar:N,O-二甲基羟胺盐酸盐,98% N,O-Dimethylhydroxylamine hydrochloride, 98%(6638-79-5)
  • 用途一:用于医药、农药的合成
  • Sigma Aldrich:6638-79-5(sigmaaldrich)
  • 海关编码:29280090
  • 用途二:有机中间体。
  • 下游产品:1,4-二乙酰基哌啶
  • 图谱信息:二甲羟胺盐酸盐(6638-79-5)Raman光谱 二甲羟胺盐酸盐(6638-79-5)红外图谱(IR1) 二甲羟胺盐酸盐(6638-79-5)质谱(MS)
  • Acros Organics:N,O-二甲基羟胺盐酸盐 N,O-Dimethylhydroxylamine hydrochloride, 98%(6638-79-5)

系列性分类


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