Ethyldiisopropylamine N,N-二异丙基乙胺

CAS 7087-68-5 MFCD00008868




Mol. FormulaC8H19N
Mol. Weight129
Refractive index1.4120 to 1.4150
Boiling Point127
Flash Point12°C(lit.)
Melting Point<-50
Vapor Pressure31 mmHg ( 37.7 °C)


Chemical NameEthyldiisopropylamine
Synonym 'HUNIG'S BASE' (CH3)2CHN(C2H5)CH(CH3)2 1,1'-Dimethyltriethylamine 1,1'-Dimethyltriethylamine 2-Propanamine,N-ethyl-N-(1-methylethyl)- Bis(1-methylethyl)ethylamine DIEA DIPEA Diisopropylethylamine HUENIG'S BASE HUNIG'S BASE N,N'-diisopropylethylamine N,N-Diisopropylethylamine N,N-Diisopropylethylamine, N,N-Diisopropylethylamine; N-Ethyldiisopropylamine; Huenig's base; DIEA; EDIA N,N-diisopropylethylamine N,N-diisopropylethylamine hydrochloride N,N-二异丙基乙胺 N,N-二异丙基乙胺/DIPEA/DIEA N-Ethyldiisopropylamine N-ethyldiisopropylamine N-乙基二异丙基胺 N-乙基二异丙胺 N-乙基二异丙胺 DIPEA `Hünig's base' 二异丙基乙胺 N-乙基二异丙胺 溶液 NEthyldiisopropylamine N,N-二异丙基乙胺 {}
MDL NumberMFCD00008868
CAS Number7087-68-5
EC Number230-392-0
Beilstein Registry Number605301
PubChem Substance ID87568082
Chemical Name TranslationN,N-二异丙基乙胺
LabNetwork Molecule IDLN00194060
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  • {SNA} Acids & Bases, Bases, Chemical Biology, Chemical Synthesis, Organic Bases,
  • {SNA}
  • {SNA} ReagentPlus, ReagentPlus Solvent Grade Products, ACS and Reagent Grade Solvents,
  • {uni_hamburg} no charge; 1fragment
  • {SNA} Chemical Synthesis, Organic Bases, Synthetic Reagents
  • {SNA} Biotech Solvents, Solvent Bottles, Solvent Packaging Options, Solvent by Application, Solvents, Sure/Seal Bottles
  • {SNA} Acids & Bases, Bases, Chemical Synthesis, Organic Bases, Synthetic Reagents
  • {SA} Chemical Biology, Chemical Synthesis, Organic Bases, Peptide Chemistry, Solvents and Mixtures for Peptide Synthesis, Synthetic Reagents


  • 常用作质子清除剂,用于肽偶联、烯醇硼化、钯(0)催化的烯丙基磷酸酯和醋酸酯的烷氧基羰基化;也可在烯基砜合成中用作催化剂。


  • Merck: 14,10482
  • Short: II/27B
  • Short: III/38B
  • Has been recommended as a base for the Horner-Wadsworth-Emmons olefination reaction, where the reagents contain groups sensitive to base-catalyzed epimerization or condensation. The reaction is carried out in the presence of LiCl, and gives high (E):(Z) ratios: Tetrahedron Lett., 25, 2183 (1984).
  • Useful base in peptide coupling reactions: J. Am. Chem. Soc., 91, 6488 (1969). See Appendix 6.
  • Merck: 14,10482 Beilstein: 4,IV,511
  • Hindered non-nucleophilic base with high proton affinity: Chem. Ber., 91, 380 (1958).
  • For use in the introduction of TBDMS protecting groups, see tert-Butyl­dimethyl­chlorosilane, A13064. Used in preparation of silyl enol ethers from both aldehydes and ketones: Helv. Chim. Acta, 60, 1801 (1977).


Signal word Danger
GHS Symbol
WGK Germany2
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Risk Statements
  • R10 Flammable 易燃
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R23 Toxic by inhalation 吸入有毒
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R52/53
  • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P312
  • P301+P330+P331+P310
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P370+P378
  • P403+P233
  • P403+P235
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupII
UN Number 2733 UN 2734 8/PG 2
Hazard Codes 3 F,C T
Hazard Class3/8
Storage condition Store in dark! 充氩保存
Warnings 危化品目录(2015)


  • 用途一:用作溶剂,用于氨基酸多肽合成等
  • TCI Shanghai:N,N-二异丙基乙胺(约10%的N,N-二甲基甲酰胺)[用于伯胺类的检出] N,N-Diisopropylethylamine (ca. 10% in N,N-Dimethylformamide) [for Detection of Primary Amines](7087-68-5)
  • 用途二:重要的有机合成中间体,主要应用于医药、农药中间体合成,也可用作溶剂、缩合剂、催化剂等。
  • MOL 文件:7087-68-5.mol
  • 溶于醇、醚等有机溶剂,呈碱性,易燃,易挥发,具有胺的气味,有刺激性。水中溶解度:3.9 g/L (20°C)。
  • Acros Organics:N,N-二异丙基乙胺 N,N-Diisopropylethylamine/1-Methyl-2-pyrrolidinone, 2 bottles kit for 2.0M solution, for peptide synt.(7087-68-5)
  • Alfa Aesar:N-乙基二异丙基胺,99% N-Ethyldiisopropylamine, 99%(7087-68-5)
  • 下游产品:N-二甲基-1,1-螺旋茚丹-7,7-二基磷铵 --> 1-BOC-3-羟甲基哌嗪 --> N-叔丁氧羰基-5,6,7,8-四氢-3-甲氧基-[1,2,4]三唑[4,3-A]吡嗪 --> 2-乙基哌嗪 --> 3-羟甲基氮杂环丁烷-1-羧酸叔丁酯 --> 1,2-双(2-氨基苯氧基)-乙烷-N,N,N`,N`-四乙酸四钠盐 --> 1,2-双(2-氨基苯氧基)-乙烷-N,N,N`,N`-四乙酸 --> 3-吖丁啶羧酸 --> 4,5-二氨基嘧啶 --> 3-Boc-氨甲基氮杂环丁烷 --> 1-Boc-3-氨甲基氮杂环丁烷 --> 1-Boc-3-氰基氮杂环丁烷 --> (R)-1-Boc-哌嗪-2-羧酸 --> 5,6,7,8-四氢吡啶并[4,3-D]嘧啶-4(3H)-酮 --> 4-氨基-5-硝基-6-氯嘧啶 --> N-(4-甲酰基吡啶-3-基)-2,2-二甲基丙酰胺 --> 5-硝基-2-糠酸甲酯 --> 4,6-二氯-5-氨基嘧啶 --> 4,6-二氯-5-硝基嘧啶 --> 4-(3-溴苯基)吗啉 --> 法罗培南钠 --> 4-羟基-5-氨基-6-氯嘧啶 --> 4,5-二氨基-6-氯嘧啶 --> 4-氯-5-氨基-6-肼基嘧啶 --> 4-乙炔基苯胺 --> 2-甲氧基-3-溴丙烯 --> 4-甲氧苄基异氰酸酯
  • 图谱信息:N,N-二异丙基乙胺(7087-68-5)红外图谱(IR1) N,N-二异丙基乙胺(7087-68-5)核磁图( 13 CNMR) N,N-二异丙基乙胺(7087-68-5)质谱(MS) N,N-二异丙基乙胺(7087-68-5)核磁图( 1 HNMR)
  • 外观性质:无色液体。
  • Sigma Aldrich:7087-68-5(sigmaaldrich)
  • F:9-34
  • 检测方法:GC,NMR
  • MSDS 信息:N-乙基二异丙胺(7087-68-5).msds
  • 海关编码:29211980
  • Hazard Note:Highly Flammable/Corrosive/Harmful
  • N,N-二异丙基乙胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010184 N,N-二异丙基乙胺;N-乙基二异丙胺; 1,1′-二甲基三乙胺 100ml 135元 2011/08/23 xw010205 N,N-二异丙基乙胺;N-乙基二异丙胺; 1,1′-二甲基三乙胺 500ml 398元 2011/04/16 D2937 N,N-二异丙基乙胺(约10%的N,N-二甲基甲酰胺)[用于伯胺类的检出] N,N-Diisopropylethylamine (ca. 10% in N,N-Dimethylformamide) [for Detection of Primary Amines] 10ML 545元