CAS 75-09-2 MFCD00000881-Dichloromethane 二氯甲烷 -LabNovo

Dichloromethane 二氯甲烷

CAS 75-09-2 MFCD00000881

化学结构图

SMILES: ClCCl

化学属性

Refractive index	n20/D 1.424(lit.)
Boiling Point	39-40
Melting Point	-97
TSCA	Yes
Autoignition Point	1223 °F
Vapor Density	2.9 (vs air)
Vapor Pressure	24.45 psi ( 55 °C)
Solubility	20 G/L (20 ºC)
Stability	对光敏感
Density	1.305
Mol. Formula	CH2Cl2
Mol. Weight	85.00
Danger-Level	乙类
pH	-:-
Redox	-

别名和识别编码

Chemical Name	Dichloromethane
Synonym	Aerothene MM CH₂Cl₂ (dichloro-methane) Dichlormethan Dichloromethane F 30 (chlorocarbon) Methane dichloride Methylenchlorid Methylene bichloride Methylene chloride Methylene dichloride R 30 R 30 (refrigerant) R-30 R30 (refrigerant) Solaesthin Solmethine dichloromethane methylene chloride 二氯甲烷亚甲基氯溶液甲叉二氯,氯化次甲基,亚甲基二氯,亚甲基氯,甲撑氯
CAS Number	75-09-2
PubChem Substance ID	6344
EC Number	200-838-9
Beilstein Registry Number	1730800
MDL Number	MFCD00000881
Reaxys-RN	1730800
Merck Number	14,6063
Chemical Name Translation	二氯甲烷
Wiswesser Line Notation	G1G
LabNetwork Molecule ID	LN00162825
InChI	InChI=1S/CH2Cl2/c2-1-3/h1H2

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分类

{SNA} 3-MCPD, Acrylamide, Adulterants, Allergens, Benzene, Beverage Testing, Bisphenol A (BPA), BADGE, BFDGE, and NOGE, Chromatography Reagents & Solvents, Derivatization of Fatty Acids to FAMEs, Dioxins/Furans/PCBs, Disinfection Product Residues and Solvents, Edible Oils, Essential Oils, FAMEs by Boiling Point Elution, FAMEs by Degree of Unsaturation, Fats (fatty acids, FAMEs, glycerides), Edible Oils, Sterols, Flavors & Fragrances, Fractionation of FAMEs Using Silver-Ion SPE, Free Fatty Acids, Furans, GC Solvents, Honey, Melamine, Mono-, Di-, and Triglycerides,
{SNA} ACS Gr

安全信息

GHS Symbol

WGK Germany2

Hazard Codes 6.1 C,N Xn

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H302 Harmful if swallowed 吞食有害
H371 May cause damage to organs 可能导致器官损伤
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H315 Causes skin irritation 会刺激皮肤
H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
H319 Causes serious eye irritation 严重刺激眼睛
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US)

RTECSPA8050000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P303+P361+P353
P304+P340
P305+P351+P338
P308+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger Warning

Safety Statements

S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥

Storage condition 储存温度2-8℃ 密封避光保存。充氩保存 0-10°C 0-10 储存温度 2-8°C ,充氩储存

UN Number 1593 1593/1912 UN1593

Packing GroupIII

Hazard Class3/6.1

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2000 ppm/5H/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-306,1986

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3500 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   4,30,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Human
DOSE/DURATION           : 500 ppm/8H
TOXIC EFFECTS :
   Behavioral - euphoria
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   176,295,1972

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 14400 ppm/7H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIHBAZ National Institutes of Health, Bulletin.  (Bethesda, MD)
   Volume(issue)/page/year: 191,1,1949

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 350 mg/kg
TOXIC EFF

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   7,205,1934

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   7,205,1934

TYPE OF TE

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 3000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 367,143,1996

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 5000 ppm/1H (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 4000 ppm/6H (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 15,991,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 6300 ppm
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   20,211,1992

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 13880 mg/m3/6H/2W (Intermittent)
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   15,221,1990

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 6628 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 116,361,1983

TYPE

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1250 ppm/7H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,84,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1250 ppm/7H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,84,1975

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4500 ppm/24H
SEX/DURATION            : female 1-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   52,29,1980

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