Methyllithium 甲基锂

CAS 917-54-4 MFCD00008253

化学结构图

917-54-4
SMILES: [Li]C

化学属性

Mol. FormulaCH3Li
Mol. Weight21.98
Density0.732
Flash Point-17°(1°F)
TSCAYes
Vapor Density3 (vs air)
Appearance 无色透明至黄色的乙醚溶液,遇水剧烈反应,易燃。沸点35℃,密度 0.702 。
Stability对空气,热和湿度敏感

别名和识别编码

Chemical NameMethyllithium
Synonym {uni_hamburg} methyl-lithiu Methyllithium solution 1-2MinEther Methyllithium lithium bromide complex solution Methyllithium, 1.6 M solution in diethyl ether (± 5% w/v) Methyllithium, 1-2M in ether, packaged under Argon in resealable ChemSealTM bottles MethyllithiumcomplexedwithlithiumbromideinethyletherMc MeLi Methyllithium (2.8% in Ethyl Ether, ca. Lithium methanide MeLi Lithiummethyl methyllithium, 1-2m in ether, packaged under argon in resealable chemseal 甲基锂, 1-2M IN ETHER, PACKAGED UNDER ARGON IN RESEALABLE 甲基锂, 1-2M IN ETHER METHYLLITHIUM Lithium methanide METHYLLITHIUM, 2.5M SOLUTION IN DIETHOX& METHYLLITHIUM SOLUTION, ~5 % IN DIETHYL ETHER Lowhalide {uni_h
CAS Number917-54-4
EC Number213-026-4
Beilstein Registry Number3587162
MDL NumberMFCD00008253
PubChem Substance ID2724049
Reaxys-RN3587162
Chemical Name Translation甲基锂
InChIKeyDVSDBMFJEQPWNO-UHFFFAOYSA-N
LabNetwork Molecule IDLN00164399
InChIInChI=1S/CH3.Li/h1H3;/q-1;+1
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分类

  • {SNA} 12 Principles Aligned Products, Alkyl, Chemical Synthesis, Greener Alternative Products, Organolithium, Organometalics, Organometallic Reagents
  • {SNA} 25mL Sure/Seal Reagents, Alkyl, Chemical Synthesis, Organic Bases, Organolithium, Organometallic Reagents, Synthetic Reagents
  • {SNA} 25mL Sure
  • {SA} 25mL Sure/Seal Reagents, Alkyl, Chemical Synthesis, Organic Bases, Organolithium, Organometallic Reagents, Synthetic Reagents
  • {SNA} Alkyl, Chemical Synthesis, Organolithium, Organometallic Reagents
  • {uni_hamburg} no charge; metal-organic; 1fragment
  • {SNA} 25mL Sure/Seal Reagents,
  • {SNA} 25mL Sure/Seal Reagents,

产品应用

  • ⑴.本品较为稳定。
  • ⑵. 碱性试剂和还原剂。用于丙二烯合成。a一轻酮转变成顺式二醇,从梭酸制酮。分解醋酸醋。使烯醇乙酸醋成烯醇负离子制a一溴代酮或a,一不饱和酮。合成螺戊烷。从丫一酮酸醋制日一二酮。与日、丫一不饱和酸反应成醋a芳香醛酮的甲基化一还.原。烯基砜的锉化。
  • ⑶. 可以对多种官能团进行甲基化,可以脱除保护基团,合成其它甲基化有机金属试剂,可以作为碱以及还原过渡金属等。溶剂和卤素对用到非溶剂化的甲基锂的反应有很大的影响。
  • ①.加成反应 ;与甲基格氏试剂相比,甲基锂与环烃、杂环以及脂肪族化合物的1,2
  • 有机催化剂反应。

相关文献及参考

  • Short: III/35C4
  • Short: III/20a
  • Short: II/2
  • Beilstein:4(4)4417

安全信息

Signal word
GHS Symbol
WGK Germany2
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用(指明具体的消防器材种类,如果用水增加危险,注明“禁止用水”
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
Risk Statements
  • R12 Extremely flammable 极端易燃
  • R15 Contact with water liberates extremely flammable gases 遇水会释放出极端易燃的气体
  • R17 Spontaneously flammable in air 在空气中能够自燃
  • R22 Harmful if swallowed 吞咽有害
  • R34 Causes burns 会导致灼伤
  • R66 Repeated exposure may cause skin dryness or cracking 反复接触可能导致皮肤干燥或皴裂
  • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
Precautionary statements
  • P222 Do not allow contact with air. 不要与空气接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P370+P378
  • P223 Keep away from any possible contact with water, because of violent reaction and possible flash fire. 远离任何与水接触的可能,因为会剧烈反应可能产生闪火。
  • P422 Store contents under… 存储目录在…之下。
  • P231+P232
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P308+P313
  • P403+P233
  • P305+P351+P338+P310
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
  • H260 In contact with water releases flammable gases which may ignite spontaneously 与水接触时释放可燃气体,可自燃。
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H250 Catches fire spontaneously if exposed to air 暴露于空气自发着火
  • H224 Extremely flammable liquid and vapour 极端易燃液体和蒸气
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupI
UN Number
Storage condition 储存温度2-8°C ,充氩保存 Air & Moisture Sensitive 2-8°C
Hazard Codes 4.2
Hazard Class4.2/4.3

其他信息

  • ⑴. 密封保存在低温、干燥并且有惰性气体保护的容器中。 ⑵. 避免与氧化物、酸、水分接触。

系列性分类


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