N-(4-((2-Imino-6-Methyl-1,2-Dihydropyrimidin-4-Yl)Amino)Phenyl)-4-(Quinolin-4(1H)-Ylideneamino)Benzamide N-[4-[(2-氨基-6-甲基-4-嘧啶基)氨基]苯基]-4-(4-喹啉基氨基)苯甲酰胺
CAS 1020149-73-8 MFCD120149738
化学结构图
SMILES: Cc1cc(Nc2ccc(NC(=O)c3ccc(Nc4ccnc5ccccc45)cc3)cc2)nc(N)n1
化学属性
| Mol. Weight | 461.52 |
|---|---|
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | N-(4-((2-Imino-6-Methyl-1,2-Dihydropyrimidin-4-Yl)Amino)Phenyl)-4-(Quinolin-4(1H)-Ylideneamino)Benzamide |
|---|---|
| Formula | C27H23N7O |
| Synonym | SGI1027; SGI 1027; SGI1027. |
| IUPAC Name | N-(4-((2-amino-6-methylpyrimidin-4-yl)amino)phenyl)-4-(quinolin-4-ylamino)benzamide |
| InChIKey | QSYLKMKIVWJAAK-UHFFFAOYSA-N |
| InChI | InChI=1S/C27H23N7O/c1-17-16-25(34-27(28)30-17)32-20-10-12-21(13-11-20)33-26(35)18-6-8-19(9-7-18)31-24-14-15-29-23-5-3-2-4-22(23)24/h2-16H,1H3,(H,29,31)(H,33,35)(H3,28,30,32,34) |
| Canonical SMILES | O=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3 |
| Chemical Name Translation | N-[4-[(2-氨基-6-甲基-4-嘧啶基)氨基]苯基]-4-(4-喹啉基氨基)苯甲酰胺 |
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产品应用
- SGI-1027 is a potent DNMT inhibitor, which reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Treatment of different cancer cell lines with SGI-1027 resulted in selective degradation of DNMT1 with minimal or no effects on DNMT3A and DNMT3B. At a concentration of 2.5 to 5 micromol/L (similar to that of decitabine), complete degradation of DNMT1 protein was achieved within 24 h without significantly affecting its mRNA level. SGI-1027 may have the potential for use in epigenetic cancer therapy.
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