Y11

CAS 1086639-59-9 MFCD186639599

化学结构图

1086639-59-9
SMILES: OCC[N+]12C[N@]3C[N@](C1)C[N@@](C2)C3.[Br-]

化学属性

Mol. Weight265.15078
Mol. FormulaC8H17BrN4O
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

CAS Number1086639-59-9
Chemical NameY11
Synonym 1-(2-Hydroxyethyl)-3,5,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane Bromide Y11; Y-11; Y 11
Chemical Name Translation
FormulaC8H17BrN4O
IUPAC Name(3r,5r,7r)-1-(2-hydroxyethyl)-1,3,5,7-tetraazaadamantan-1-ium bromide.
Canonical SMILESOCC[N+]12C[N@]3C[N@](C2)C[N@](C3)C1.[Br-]
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分类

  • Heterocycles
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Y11 is a small molecule inhibitor targeting Y397 site of FAK. Y11 significantly and specifically decreased FAK autophosphorylation, directly bound to the N-terminal domain of FAK. In addition, Y11 decreased Y397-FAK autophosphorylation, inhibited viability and clonogenicity of colon SW620 and breast BT474 cancer cells and increased detachment and apoptosis in vitro. Moreover, Y11 significantly decreased tumor growth in the colon cancer cell mouse xenograft model. Finally, tumors from the Y11-treated mice demonstrated decreased Y397-FAK autophosphorylation and activation of poly (ADP ribose) polymerase and caspase-3.

相关文献及参考

  • Xing, Z., et al.: Mol. Biol. Cell, 5, 413 (1994),
  • Halder, J., et al.: Clin. Cancer Res., 11, 8829 (2005),
  • Beierle, E., et al.: J. Biol. Chem., 282, 12503 (2007),

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FAK
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. FAK

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