N-Methyl-4-(4-(3-(Trifluoromethyl)Benzamido)Phenoxy)Picolinamide N-甲基-4-(4-(3-(三氟甲基)苯甲酰氨基)苯氧基)吡啶-2-甲酰胺

CAS 1125780-41-7 MFCD20261423

化学结构图

1125780-41-7
SMILES: CNC(=O)c1cc(Oc2ccc(NC(=O)c3cccc(C(F)(F)F)c3)cc2)ccn1

化学属性

Mol. Weight415.36525
Appearance white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameN-Methyl-4-(4-(3-(Trifluoromethyl)Benzamido)Phenoxy)Picolinamide
FormulaC21H16F3N3O3
Synonym SKLB610; SKLB 610; SKLB-610.
IUPAC NameN-methyl-4-(4-(3-(trifluoromethyl)benzamido)phenoxy)picolinamide
InChIKeyWACDHHMEVMSODJ-UHFFFAOYSA-N
InChIInChI=1S/C21H16F3N3O3/c1-25-20(29)18-12-17(9-10-26-18)30-16-7-5-15(6-8-16)27-19(28)13-3-2-4-14(11-13)21(22,23)24/h2-12H,1H3,(H,25,29)(H,27,28)
Canonical SMILESO=C(NC)C1=NC=CC(OC2=CC=C(NC(C3=CC=CC(C(F)(F)F)=C3)=O)C=C2)=C1
Chemical Name TranslationN-甲基-4-(4-(3-(三氟甲基)苯甲酰氨基)苯氧基)吡啶-2-甲酰胺
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产品应用

  • SKLB610 is a VEGFR inhibitor that potently suppresses human tumor angiogenesis. SKLB610 inhibited angiogenesis-related tyrosine kinase VEGFR2, fibroblast growth factor receptor 2 (FGFR2) and platelet-derived growth factor receptor (PDGFR) at rate of 97%, 65% and 55%, respectively, at concentration of 10μM in biochemical kinase assays. SKLB610 exhibited its antitumor activity as a multi-targeted inhibitor with more potent inhibition of VEGFR2 activity. Its potential to be a candidate of anticancer agent is worth being further investigated.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. PDGFR

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