4-[4-Fluoro-3-[(4-Methoxy Piperidin-1-Yl)Carbonyl]Benzyl]Phthalazine-1(2H)-One 4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮
CAS 1174043-16-3 MFCD274043163
化学结构图
SMILES: COC1CCN(C(=O)c2cc(Cc3n[nH]c(=O)c4ccccc34)ccc2F)CC1
化学属性
| Mol. Weight | 395.43 |
|---|---|
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 4-[4-氟-3-[(4-甲氧基哌啶-1-基)羰基]苄基]酞嗪-1(2H)-酮 |
|---|---|
| Chemical Name | 4-[4-Fluoro-3-[(4-Methoxy Piperidin-1-Yl)Carbonyl]Benzyl]Phthalazine-1(2H)-One |
| Formula | C22H22FN3O3 |
| Synonym | AZD2461; AZD-2461; AZD 2461. |
| IUPAC Name | 4-(4-fluoro-3-(4-methoxypiperidine-1-carbonyl)benzyl)phthalazin-1(2H)-one |
| InChIKey | HYNBNUYQTQIHJK-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H22FN3O3/c1-29-15-8-10-26(11-9-15)22(28)18-12-14(6-7-19(18)23)13-20-16-4-2-3-5-17(16)21(27)25-24-20/h2-7,12,15H,8-11,13H2,1H3,(H,25,27) |
| Canonical SMILES | O=C1NN=C(CC2=CC=C(F)C(C(N3CCC(OC)CC3)=O)=C2)C4=C1C=CC=C4 |
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产品应用
- AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein. AZD2641 is currently in Phase I clinical study. The study is being conducted to see how it may work to treat solid tumors. The main purpose is to establish a safe dosage of the drug and provide additional information on any potential side effects this drug may cause. The study will also assess the blood levels and action of AZD2461 in the body over a period of time and will indicate whether the drug has a therapeutic effect on solid tumors.
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