(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-Yl)Ethoxy)-1H-Indazol-3-Yl)Vinyl)-1H-Pyrazol-1-Yl)Ethan-1-Ol (R,E)-2-(4-(2-(5-(1-(3,5-二氯吡啶-4-基)乙氧基)-1H-吲唑-3-基)乙烯基)-1H-吡唑-1-基)乙醇

CAS 1254473-64-7 MFCD354473647

化学结构图

1254473-64-7
SMILES: C[C@@H](Oc1ccc2[nH]nc(/C=C/c3cnn(CCO)c3)c2c1)c1c(Cl)cncc1Cl

化学属性

Mol. Weight444.31
Appearance Yellow solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation(R,E)-2-(4-(2-(5-(1-(3,5-二氯吡啶-4-基)乙氧基)-1H-吲唑-3-基)乙烯基)-1H-吡唑-1-基)乙醇
Chemical Name(R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-Yl)Ethoxy)-1H-Indazol-3-Yl)Vinyl)-1H-Pyrazol-1-Yl)Ethan-1-Ol
FormulaC21H19Cl2N5O2
Synonym LY2874455; LY 2874455; LY-2874455.
IUPAC Name(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol.
InChIKeyGKJCVYLDJWTWQU-CXLRFSCWSA-N
InChIInChI=1S/C21H19Cl2N5O2/c1-13(21-17(22)10-24-11-18(21)23)30-15-3-5-20-16(8-15)19(26-27-20)4-2-14-9-25-28(12-14)6-7-29/h2-5,8-13,29H,6-7H2,1H3,(H,26,27)/b4-2+/t13-/m1/s1
Canonical SMILESC[C@H](C1=C(Cl)C=NC=C1Cl)OC2=CC3=C(NN=C3/C=C/C4=CN(CCO)N=C4)C=C2
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产品应用

  • LY2874455 is a novel and potent FGF/FGFR Inhibitor. It exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FGFR

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