(5-Amino-1-(2-Methyl-1H-Benzo[D]Imidazol-6-Yl)-1H-Pyrazol-4-Yl)(1H-Indol-2-Yl)Methanone (5-氨基-1-(2-甲基-1H-苯并[d]咪唑-6-基)-1H-吡唑-4-基)(1H-吲哚-2-基)甲酮

CAS 1265229-25-1 MFCD365229251

化学结构图

1265229-25-1
SMILES:

化学属性

Mol. Weight356.38
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation(5-氨基-1-(2-甲基-1H-苯并[d]咪唑-6-基)-1H-吡唑-4-基)(1H-吲哚-2-基)甲酮
Chemical Name(5-Amino-1-(2-Methyl-1H-Benzo[D]Imidazol-6-Yl)-1H-Pyrazol-4-Yl)(1H-Indol-2-Yl)Methanone
FormulaC20H16N6O
Synonym Debio-1347; Debio 1347; Debio1347; CH5183284; CH 5183284; CH-5183284; FF284; FF-284; FF 284.
IUPAC Name(5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone
InChIKeyBEMNJULZEQTDJY-UHFFFAOYSA-N
InChIInChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24)
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产品应用

  • Debio-1347, also known as FF284 and CH5183284, is an orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Angiogenesis
  3. FGFR

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