(4-((4-(Ethylamino)-5-(Trifluoromethyl)Pyrimidin-2-Yl)Amino)-2-Fluoro-5-Methoxyphenyl)(Morpholino)Methanone (4-((4-(乙基氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-2-氟-5-甲氧基苯基)(吗啉代)甲酮

CAS 1351761-44-8 MFCD451761448

化学结构图

1351761-44-8
SMILES: CCNc1nc(Nc2cc(F)c(C(=O)N3CCOCC3)cc2OC)ncc1C(F)(F)F

化学属性

Mol. Weight443.39535
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name(4-((4-(Ethylamino)-5-(Trifluoromethyl)Pyrimidin-2-Yl)Amino)-2-Fluoro-5-Methoxyphenyl)(Morpholino)Methanone
FormulaC19H21F4N5O3
Synonym GNE7915; GNE 7915; GNE-7915.
IUPAC Name(4-((4-(ethylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2-fluoro-5-methoxyphenyl)(morpholino)methanone
InChIKeyXCFLWTZSJYBCPF-UHFFFAOYSA-N
InChIInChI=1S/C19H21F4N5O3/c1-3-24-16-12(19(21,22)23)10-25-18(27-16)26-14-9-13(20)11(8-15(14)30-2)17(29)28-4-6-31-7-5-28/h8-10H,3-7H2,1-2H3,(H2,24,25,26,27)
Canonical SMILESO=C(C1=CC(OC)=C(NC2=NC=C(C(F)(F)F)C(NCC)=N2)C=C1F)N3CCOCC3
Chemical Name Translation(4-((4-(乙基氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-2-氟-5-甲氧基苯基)(吗啉代)甲酮
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产品应用

  • GNE-7915 is a potent LRRK2 kinase inhibitor, which possess an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. GNE-7915 was reported as a potent (IC50=9 nM) selective (1/187 kinases), brain-penetrant and non-toxic inhibitor of LRRK2.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Autophagy
  3. LRRK2

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