GNE-0877

CAS 1374828-69-9 MFCD N/A

化学结构图

1374828-69-9
SMILES: CNc1nc(Nc2cn(C(C)(C)C#N)nc2C)ncc1C(F)(F)F

化学属性

Mol. Weight339.31895
Appearance white to off-white solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name Translation
Chemical NameGNE-0877
FormulaC14H16F3N7
Synonym GNE0877; GNE 0877; GNE-0877.
IUPAC Name2-methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)propanenitrile .
InChIKeyZPPUMAMZIMPJGP-UHFFFAOYSA-N
InChIInChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
Canonical SMILESCC(N1N=C(C)C(NC2=NC=C(C(F)(F)F)C(NC)=N2)=C1)(C)C#N
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品牌质保精细包装    现货库存    一流品牌服务   

产品应用

  • GNE-0877 is a highly potent and selective LRRK2 inhibitor. Leucine-rich repeat kinase 2 (LRRK2) has drawn significant interest in the neuroscience research community because it is one of the most compelling targets for a potential disease-modifying Parkinson's disease therapy.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Autophagy
  3. LRRK2

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