AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells. AG14361

CAS 328543-09-5 MFCD28543095

化学结构图

328543-09-5
SMILES: CN(C)Cc1ccc(-c2nc3cccc4c3n2CCNC4=O)cc1

化学属性

Mol. FormulaC19H20N4O
Mol. Weight320.3883
Appearance Solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameAG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells.
Chemical Name TranslationAG14361
Chemicalbook IDCB72525863
FormulaC19H20N4O
Synonym AG14361; AG-14361; AG 14361.
IUPAC Name1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one.
InChIKeySEKJSSBJKFLZIT-UHFFFAOYSA-N
InChIInChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
Canonical SMILESO=C1C2=C3C(N=C(C4=CC=C(CN(C)C)C=C4)N3CCN1)=CC=C2
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产品应用

  • AG14361 is a PARP-1 inhibitor with Ki < 5 nmol/L. AG14361 is at least 1000-fold more potent than the benzamides. The IC50 for AG14361 is 29 nM in permeabilized SW620 cells and 14 nM in intact SW620 cells.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. DNA Damage
  3. PARP
  1. Medical Research Areas
  2. Epigenetics
  3. PARP

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