6-((2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2(1H)-ylidene)amino)ethyl)imino)-3-nitro-1,6-dihydropyridin-2-amine N2-(2-((4-(2,4-二氯苯基)-5-(1H-咪唑-2-基)嘧啶-2-基)氨基)乙基)-5-硝基吡啶-2,6-二胺
CAS 556813-39-9 MFCD56813399
化学结构图
SMILES: Nc1nc(NCCNc2ncc(-c3ncc[nH]3)c(-c3ccc(Cl)cc3Cl)n2)ccc1[N+](=O)[O-]
化学属性
| Mol. Weight | 486.31 |
|---|---|
| Mol. Formula | C20H17Cl2N9O2 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| CAS Number | 556813-39-9 |
|---|---|
| Chemical Name | 6-((2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2(1H)-ylidene)amino)ethyl)imino)-3-nitro-1,6-dihydropyridin-2-amine |
| Synonym | CHIR98014; CHIR-98014; CHIR 98014; CT 98024; CT-98024; CT98024; Chir 98014 Chir-98014 Chir98014 N6-[2-[[4-(2,4-Dichlorophenyl)-5-(1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro- |
| Chemical Name Translation | N2-(2-((4-(2,4-二氯苯基)-5-(1H-咪唑-2-基)嘧啶-2-基)氨基)乙基)-5-硝基吡啶-2,6-二胺 |
| LabNetwork Molecule ID | LN00200946 |
| PubChem Substance ID | 9957049 |
| InChI | InChI=1S/C20H17Cl2N9O2/c21-11-1-2-12(14(22)9-11)17-13(19-25-6-7-26-19)10-28-20(30-17)27-8-5-24-16-4-3-15(31(32)33)18(23)29-16/h1-4,6-7,9-10H,5,8H2,(H,25,26)(H3,23,24,29)(H,27,28,30) |
| Formula | C20H17Cl2N9O2 |
| IUPAC Name | N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine |
| InChIKey | NDFXSHIIGXVOKT-UHFFFAOYSA-N |
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分类
- Amines
- Aromatics
- Heterocycles
- Inhibitors
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- CHIR98014, also known as CT-98024, is a reversible, cell-permeable inhibitor of GSK3α and GSK3β (IC50 = 0.65 and 0.58 nM, respectively). It is inactive against a series of other serine/threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin-dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also reduces tau phosphorylation in rat brains and supports Wnt signaling during osteogenesis.
相关文献及参考
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安全信息
- H301 Toxic if swallowed 吞食有毒
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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