Apremilast 阿普斯特

CAS 608141-41-9 MFCD08141419

化学结构图

608141-41-9
SMILES: CCOc1cc([C@@H](CS(C)(=O)=O)N2C(=O)c3cccc(NC(C)=O)c3C2=O)ccc1OC

化学属性

Mol. FormulaC22H24N2O7S
Mol. Weight461
Appearance White to off-white powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical NameApremilast
Chemical Name Translation阿普斯特
LabNetwork Molecule IDLN00216442
FormulaC22H24N2O7S
Synonym CC10004; CC-10004; CC 10004; Apremilast; brand name: Otezla.
IUPAC Name(S)-N-(2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxoisoindolin-4-yl)acetamide
InChIKeyIMOZEMNVLZVGJZ-QGZVFWFLSA-N
InChIInChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
Canonical SMILESCC(NC1=CC=CC(C(N2[C@@H](C3=CC=C(OC)C(OCC)=C3)CS(=O)(C)=O)=O)=C1C2=O)=O
MDL Number
CAS Number608141-41-9
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产品应用

  • Apremilast, also known as CC-10004, is a thalidomide analog and is an orally available small molecule inhibitor of phosphodiesterase 4 (PDE4). Apremilast specifically inhibits PDE4 and inhibits spontaneous production of TNF-alpha from human rheumatoid synovial cells. It has anti-inflammatory activity. Apremilast was approved by the USFDA in March 2014 for treatment of adults with active psoriatic arthritis. It is also being tested for its efficacy in treating other chronic inflammatory diseases such as ankylosing spondylitis, Behcet's disease, and rheumatoid arthritis.

安全信息

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Medical Research Areas
  2. Apoptosis
  3. TNF-alpha

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