NVP-TAE 226 2-[[5-氯-2-[[2-甲氧基-4-(4-吗啉)苯基]氨基]-4-嘧啶]氨基]-N-甲基苯甲酰胺
CAS 761437-28-9 MFCD61437289
化学结构图
SMILES: CNC(=O)c1ccccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2OC)ncc1Cl
化学属性
| Mol. Weight | 468.936 |
|---|---|
| Appearance | White to light yellow solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name Translation | 2-[[5-氯-2-[[2-甲氧基-4-(4-吗啉)苯基]氨基]-4-嘧啶]氨基]-N-甲基苯甲酰胺 |
|---|---|
| Chemical Name | NVP-TAE 226 |
| Formula | C23H25ClN6O3 |
| Synonym | NVPTAE226, NVP TAE226, NVP-TAE226, TAE226, TAE226, TAE 226 |
| IUPAC Name | 2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide |
| InChIKey | UYJNQQDJUOUFQJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C23H25ClN6O3/c1-25-22(31)16-5-3-4-6-18(16)27-21-17(24)14-26-23(29-21)28-19-8-7-15(13-20(19)32-2)30-9-11-33-12-10-30/h3-8,13-14H,9-12H2,1-2H3,(H,25,31)(H2,26,27,28,29) |
| Canonical SMILES | O=C(NC)C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCOCC4)C=C3OC)=NC=C2Cl |
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产品应用
- TAE226 is a novel and potent ATP competitive inhibitor of FAK and IGF-IR with potential anticancer activity. TAE226 can block FAK and IGF-IR signaling pathways. TAE226 inhibited the phosphorylation of FAK as well as the downstream effectors AKT, extracellular signal-related kinase, and S6 ribosomal protein in multiple glioma cell lines. TAE226 induced a concentration-dependent decrease in cellular proliferation with an associated G(2) cell cycle arrest in every cell line and an increase in apoptosis in a cell-line-specific manner. TAE226 also decreased glioma cell adhesion, migration, and invasion through an artificial extracellular matrix.
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