Trifluoromethanesulfonic anhydride 三氟甲磺酸酐
CAS 358-23-6 MFCD00000408
化学结构图
SMILES: O=S(=O)(OS(=O)(=O)C(F)(F)F)C(F)(F)F
化学属性
| Refractive index | 1.3210 to 1.3230 |
|---|---|
| Vapor Density | 5.2 (vs air) |
| Vapor Pressure | 8 mmHg ( 20 °C) |
| TSCA | Yes |
| Melting Point | -80°C |
| Solubility | 起反应 VIOLENTLY WITH WATER |
| Flash Point | 81-83°C |
| Mol. Formula | C2F6O5S2 |
| Mol. Weight | 282 |
| Density | 1.677 |
| Appearance | colorless liq. |
| Stability | moisture sensitive |
| Boiling Point | 81-83°C |
| pH | :A |
别名和识别编码
| Chemical Name | Trifluoromethanesulfonic anhydride |
|---|---|
| Synonym | TRIFLUOROMETHANESULFONIC ACID ANHYDRIDE Trifluoromethylsulfonic acid anhydride Trifluoromethanesulphonicanhydride99% trifluormethanesulfonic anhydride TRIFLUOROMETHANESULFONYL ANHYDRIDE 三氟甲烷磺酸酐 三氟甲磺酸酐 溶液 Tirflic anhydride TRIFLUOROMETHANESULFONIC ANHYDRIDE SET W ITH 10 X 1 ML Perfluoromethanesulfonic anhydride solution 三氟甲烷磺酸酐 溶液 Trifluoromethanesulfonic acid anhydride TRIFLIC ANHYDRIDE 三氟甲磺酸酐，三氟甲基磺酸酐 TriFluoroMethaneSulfonic Anhydride（TFMSAA） Trifluoromethanesulfonic anhydride ######## Trifluoromethanesulfonicanhydride,98% Trifluorme TRIFLUOROMETHANESULFONIC ANHYDRIDE, 99+% Trifluoromethanesufonic anhydride {uni_ |
| EC Number | 206-616-8 |
| Beilstein Registry Number | 1813600 |
| PubChem Substance ID | 67749 |
| Reaxys-RN | 1813600 |
| Chemical Name Translation | 三氟甲磺酸酐 |
| LabNetwork Molecule ID | LN00008016 |
| InChI | InChI=1S/C2F6O5S2/c3-1(4,5)14(9,10)13-15(11,12)2(6,7)8 |
| MDL Number | MFCD00000408 |
| CAS Number | 358-23-6 |
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分类
- {SNA} Chemical Reagents, Chemical Synthesis, Coupling, Development Quantities for Research, Synthetic Reagents, Triflate Formation
- {uni_hamburg}
- Aliphatics
- {SNA} Chemical Synthesis, Coupling, Synthetic Reagents, Triflate Formation
- Miscellaneous Reagents
产品应用
- 广泛地用于合成烷基和乙烯基三氟甲基磺酸盐。在化工和制药合成中，催化应用于三氟酐、酸和酯。
相关文献及参考
- For use in the Vilsmeier formylation of less active substrates, see N,N-Dimethylformamide, A13547.
- Beilstein: 3,IV,35
- Enolizable carbonyl compounds in the presence of base can be converted to vinyl (enol) triflates: Synthesis, 85 (1982); Org. Synth. Coll., 6, 757 (1988). For conditions employing preferred base, 2,6-Di-tert-butyl-4-methylpyridine, L14143, see: Org. Synth. Coll., 8, 97, 126 (1993). Enol triflates behave as a source of vinyl cations. For reviews, see: Angew. Chem. Int. Ed., 17, 333 (1978);
- Cai, D. et al.: Org. Synth., 10, 112 (2004);
- Enolizable carbonyl compounds in the presence of base can be converted to vinyl (enol) triflates: Synthesis, 85 (1982); Org. Synth. Coll., 6, 757 (1988). For conditions
- For formation of keteniminium triflates, see N,N-Dimethylacetamide, A10924.
- Short: EINECS
- For a review of chemical transformations induced by the reagent, see: Tetrahedron, 56, 3077 (2000). For a brief feature on uses in synthesis, see: Synlett, 390 (2004).
- Enolizable carbonyl compounds in the presence of base can be converted to vinyl (enol) triflates: Synthesis, 85 (1982); Org. Synth. Coll., 6, 757 (1988). For conditions employing preferred base, 2,6-Di-tert-butyl-4-methylpyridine, L14143, see: Org. Synth. Coll., 8, 9
- Enolizable carbonyl compounds in the presence of base can be converted to vinyl (enol) triflates: Synthesis, 85 (1982); Org. Synth. Coll., 6, 757 (1988). For conditions employing preferred base, 2,6-Di-tert-butyl-4-methylpyridine, L14143, see: Org. Synth. Coll., 8, 97, 126 (1993
- The Ritter reaction is normally most successful with tertiary alcohols. In contrast, a useful variation allows conversion of primary or secondary alcohols to amides in good yield: Tetrahedron Lett., 30, 581 (1989):
- Triflic anhydride has also been found to promote the nitration of arenes, even deactivated ones, under mild conditions: Synth
安全信息
GHS Symbol
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S43 In case of fire use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add -?Never use water) 着火时使用（指明具体的消防器材种类，如果用水增加危险，注明“禁止用水”
- S8 Keep container dry 保持容器干燥；
- S30 Never add water to this product 切勿将水加入该产品中；
- S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
- R35 Causes severe burns 会导致严重灼伤
- R14 Reacts violently with water 遇水会猛烈反应
- R22 Harmful if swallowed 吞咽有害
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
- P303+P361+P353+P310+P363
- P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P330+P331
- P405 Store locked up. 上锁保管。
- P304+P340
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P304+P340+P310
- H290 May be corrosive to metals 可能腐蚀金属。
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H302 Harmful if swallowed 吞食有害
- H351 Suspected of causing cancer 怀疑致癌
其他信息
- 接触空气发烟、吸湿性、带有刺激性气味的液体,和水能剧烈反应。
- 上游原料:五氧化二磷 --> 三氟甲磺酸
- TCI Shanghai:三氟甲磺酸酐 Trifluoromethanesulfonic Anhydride,>;98.0%(T)(358-23-6)
- 下游产品:(S)-7,7'-双[二(3,5-二甲基苯基羟亚磷基))-1,1'-螺二氢茚 --> (R)-7,7'-二联苯羟亚膦-1,1'-螺旋菌 --> (S)-7,7'-双(二苯基磷酰)-1,1'-螺二氢茚 --> (S)-7,7'-双[二(对甲基苯基羟亚磷基))-1,1'-螺二氢茚 --> 1-氟-4-(三氟甲基硫代)苯 --> 双二苯基磷酰联萘 --> 双二苯基磷酰联萘 --> 2-乙酰基-3-氨基吡啶 --> S-(-)-1,1'-联萘-2,2'-双二苯膦 --> N-苯基双(三氟甲烷磺酰)亚胺 --> 5-氨基-1,2,3-噻重氮-4-羧酸乙酯 --> 二甲基异唑四异氰酸酯 --> 2-(三甲基硅)苯基三氟甲烷磺酸盐 --> 曲格列酮
- 用途一:化工中间体 无色澄清液体
- MSDS 信息:Trifluoromethanesulfonic anhydride(358-23-6).msds
- 三氟甲磺酸酐价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L0815102 三氟甲烷磺酸酐98％ 50g 1800元 2011/04/16 T1100 三氟甲磺酸酐 Trifluoromethanesulfonic Anhydride 10G 550元 2011/04/16 T1100 三氟甲磺酸酐 Trifluoromethanesulfonic Anhydride 250G 5500元
- 图谱信息:三氟甲磺酸酐(358-23-6)质谱(MS) 三氟甲磺酸酐(358-23-6)红外图谱(IR1) 三氟甲磺酸酐(358-23-6)核磁图( 13 CNMR)
- 蒸气密度:5.2 (vs air)
- Alfa Aesar:三氟甲烷磺酸酐,98% Trifluoromethanesulfonic anhydride, 98%(358-23-6)
- 用途二:广泛地用于合成烷基和乙烯基三氟甲基磺酸盐。在化工和制药合成中，催化应用于三氟酐、酸和酯。
- 蒸气压:8 mm Hg ( 20 °C)
- MOL 文件:358-23-6.mol
- Hazard Note:Corrosive
- F:10-21
- 存储注意事项:氮气保护
- Acros Organics:三氟甲烷磺酸酐 Trifluoromethanesulfonic anhydride, 98+%(358-23-6)
- 敏感性:Moisture Sensitive
- 海关编码:29049020
- Sigma Aldrich:358-23-6(sigmaaldrich)
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