Cyclohexylamine 环己胺

CAS 108-91-8 MFCD00001486

化学结构图

108-91-8
SMILES: NC1CCCCC1

化学属性

Mol. FormulaC6H13N
Mol. Weight99.17
Density0.867
Refractive index1.4580 to 1.4600
Autoignition Point559 °F
Vapor Density3.42 (vs air)
Boiling Point-
Vapor Pressure10 mmHg ( 22 °C)
Melting Point-17
Flash Point-
TSCAYes
Solubility溶于水，可混溶于多数有机溶剂。
Stability对湿度和空气敏感

别名和识别编码

Chemical NameCyclohexylamine
CAS Number108-91-8
EC Number203-629-0
Beilstein Registry Number471175
MDL Number-
Synonym Cyclohexylamine {LY} Cyclohexylamine {} {LY} Cyclohexylamine {} {} {LY} Cyclohexylamine {} {} {} {LY} Cyclohexylamine {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclohexylamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cycloh
Merck Number2729
PubChem Substance ID7965
Reaxys-RN471175
Chemical Name Translation环己胺
Wiswesser Line NotationL6TJ AZ
LabNetwork Molecule IDLN00001939
InChIInChI=1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2
Canonical SMILESNC1CCCCC1
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分类

  • {Chemicalbook} 农药中间体: 除草剂中间体: 除草剂中间体
  • {uni_hamburg} no charge; carbocycle; alicycle; 6RingOnly; 6ring; 1fragment
  • {SNA} Amines, Building Blocks, C6, Chemical Synthesis, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 酸性气体吸收剂，有机合成。

相关文献及参考

  • Merck:14,2729 Beilstein:12,5
  • Short: III/47
  • Short: III/38B
  • Short: II/5
  • Merck:14,2729
  • For protection of an aldehyde as its cyclohexyl imine, see, e.g.: Org. Synth. Coll., 8, 586 (1993). Cyclohexyl imines of aldehydes have found use in the directed aldol synthesis: reaction with a less reactive ketone takes place in preference to self-condensation of the aldehyde. See, e.g.: Org. Synth. Coll., 6, 901 (1988):

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Risk Statements
  • R10 Flammable 易燃
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R34 Causes burns 会导致灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310
  • P301+P330+P331+P310
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P403+P233
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H301+H311
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302 Harmful if swallowed 吞食有害
  • H302+H312
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSGX0700000
Packing GroupII
UN Number 2357 UN 2357 8/PG 2 UN2357
Storage condition RT, stored under argon {LY} RT, stored under argon {} {LY} RT, stored under argon {} {} {LY} RT, stored under argon {} {} {} {LY} RT, stored under argon {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under argon {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} RT, stored under
Hazard Codes 8 C T
Hazard Class8/3
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal

T

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Vascular - shock
   Liver - other changes
REFERENCE :
   AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
   (Chicago, IL)  V.2-10, 1950-54. For publisher information, see AEHLAU.
   Volume(issue)/page/year: 5,311,1952

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 150 ppm/7H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IMSUAI Industrial Medicine and Surgery.  (Northbrook, IL)  V.18-42, 1949-73.
    For publisher information, see IOHSA5.  Volume(issue)/page/year:
   19,317,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 770 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   14,654,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 320 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIHAAP American Industrial Hygiene Association Journal.  (AIHA, 475 Wolf
   Ledges Pkwy., Akron, OH 44311)  V.19-    1958-  Volume(issue)/page/year:

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - hamster Leukocyte
DOSE/DURATION           : 450 mg/kg/3D (Continuous)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 31,5,1975

TYPE OF TEST            : Dominant lethal test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 500 mg/kg/5D (Intermittent)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 14,126,1972

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 10 umol/L/5H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 39,1,1976

TYPE OF TEST            : Specific locus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
REFERENCE :
   PCBRD2 Progress in Clinical and Biological Research.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1975- Volume(issue)/page/year:
   109,339,1982

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Mammal - domestic
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,407,1974

TYPE OF TEST

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - species unspecified Kidney
DOSE/DURATION           : 50 mg/L/8H (Continuous)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (Lon

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 10,29,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5600 mg/kg
SEX/DURATION            : male 4 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 19,291,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 120 mg/kg
SEX/DURATION            : female 6-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   SEIJBO Senten Ijo.  Congenital Anomalies.  (Nippon Senten Ijo Gakkai, c/o
   Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
   Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
   information, see CGANE7.  Volume(issue)/page/year: 11,51,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 77 mg/kg

Restrict 危险品

其他信息

  • 理化性质:环己胺又称氨基环己烷、六氢苯胺。无色透明液体。有强烈的鱼腥味和氨气味。易燃。相对分子质量99.18。相对密度0.8191。熔点-17.7℃。沸点 134.5℃、118.9℃(6.67×104Pa)、 102.5℃(4.00×104Pa)、72.0℃ (1.33×104Pa)、56.0℃(6.67×103Pa)、45.1℃ (4.00×103Pa)、41.3℃(3.33×103Pa)、36.4℃ (2.67×103Pa)、30.5℃(1.99×103Pa)、25.0℃ (1.17×103Pa)。折射率1.4372。闪点32℃。燃点265℃。溶于水，能与乙醇、乙醚、丙酮、乙酸乙酯、氯仿、庚烷、苯等一般有机溶剂混溶。环己胺能随水蒸气一起挥发。能吸收空气中的二氧化碳，形成白色结晶的碳酸盐。与水形成共沸物，共沸点96.4℃，含水55.8%。水溶液呈碱性。0.01%浓度的水溶液pH=10.5。其蒸气与空气形成爆炸混合物。本品有毒，刺激皮肤和粘膜，引起坏疽;吸入其蒸气时，有麻醉作用，但不会引起血液中毒。大鼠经口LD50710mg/kg。工作场所最高允许浓度10×10-6。 环己胺与碘化氢于封管中在200℃共热得甲基环戊烷，在乙醚中与硫酸二甲酯共热得甲基环己胺及少量二甲基环己胺，其盐酸盐与亚硝酸钠作用得环己醇，与过量氨及氯化锌反应可得到2-甲基吡啶。 制备方法：可由苯胺在高温、高压下进行催化(镍或钴)还原而制得环己胺成品;也可由苯酚经催化还原得到的环己醇、环己酮为原料，再与氨进行胺化而制得。工业上环己胺主要用作橡胶的噻唑类硫化促进剂，也可用作清罐剂、染色助剂和表
  • 防护措施:环已胺呈强碱性，因此刺激皮肤和粘膜。吸入蒸气可引起恶心和
  • 防护措施:环已胺呈强碱性，因此刺激皮肤和粘膜。吸入蒸气可引起恶心和麻醉，经皮肤吸收能引起过敏症。小鼠吸入LC100为4.3mg
  • 凝固点:-17.7℃
  • 主要用途:环己胺可用作表面活性剂的原料，生产烷基苯磺酸环己胺，用于乳化剂及发泡剂; 香料原料，生产环己基丙酸烯丙酯; 染料原料，生产酸性蓝62、分散荧光黄、分散荧光黄H5GL、弱酸性蓝BRN、分散蓝6和染料助剂; 食品添加剂甜味料的原料;环己胺可用于生产环己胺磺酸盐和环己基氨基磺酸
  • 毒性分级:高毒
  • 主要用途:环己胺可用作表面活性剂的原料，生产烷基苯磺酸环己胺，用于乳化剂及发泡剂; 香料原料，生产环己基丙酸烯丙酯; 染料原料，生产酸性蓝62、分散荧光黄、分散荧光黄H5GL、弱酸性蓝BRN、分
  • 用途三:用作橡胶硫化促进剂，也用作合成纤维、染料、气相缓蚀剂的原料
  • 理化性质:环己胺又称氨基环己烷、六氢苯胺。无色透明液体。有强烈的鱼腥味和氨气味。易燃。相对分子质量99.18。相对密度0.8191。熔点-17.7℃。沸点 134.5℃、118.9℃(6.67×104Pa)、 102.5℃(4.00×104Pa)、72.0℃ (1.33×104Pa)、56.0℃(6.67×103Pa)、45.1℃ (4.00×103Pa)、41.3℃(3.33×103Pa)、36.4℃ (2.67×103Pa)、30.5℃(1.99×103Pa)、25.0℃ (1.17×103Pa)。折射率1.4372。闪点32℃。燃点265℃。溶于水，能与乙醇、乙醚、丙酮、乙酸乙酯、氯仿、庚烷、苯等一般有机
  • 职业标准:TWA 40 毫克/ 立方米
  • 用途五:本品用以制备环己醇、环己酮、己内酰胺、醋酸纤维和尼龙6等。环己胺本身为溶剂，可在树脂、涂料、脂肪、石蜡油类中应用。也可用于制取脱硫剂、橡胶抗氧剂、硫化促进剂、塑料及纺织品化学助剂、锅炉给水处理剂、金属缓蚀剂、乳化剂、防腐剂、抗静电剂、胶乳凝固剂、石油添加剂、杀菌剂、杀虫剂及染料中间体。环己胺的磺酸盐，作为人工甘味料，用于食品、饮料和医药。
  • 环己胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80040118 环己胺;六氢苯胺; 氨基环己烷 500ml 24元 2011/08/23 80040128 环己胺;六氢苯胺; 氨基环己烷 500ml 23元 2011/08/23 xp400382 环己胺;六氢苯胺; 氨基环己烷 5ml 45元
  • 用途六:酸性气体吸

系列性分类

  1. C6 - Amines
  1. C10 - Amines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amines 胺
  6. C11 to C38