Hexachlorophene 六氯酚

CAS 70-30-4 MFCD00002171

化学结构图

70-30-4
SMILES: Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl

化学属性

Mol. FormulaCH2[C6H(Cl)3OH]2
Mol. Weight406.90
Melting Point163-165 °C(lit.)
Flash Point11 °C
Appearance crystalline
Solubility不溶于水,溶于醇、丙酮、乙醚、氯仿、丙二醇、油类、稀碱液。
Density1.713

别名和识别编码

Chemical NameHexachlorophene
CAS Number70-30-4
Synonym AT 7 2,2'-亚甲基双(3,4,6-三氯苯酚) bis(3,5,6-trichloro-2-hydroxy phenyl)methane Hexa HCP Bis(2-hydroxy-3,5,6-trichlorophenyl)methane SERIBAK Gamophene Compound G-11 2,2'-Methylenebis(3,4,6-trichlorophenol) DIHYDROXYHEXACHLORODIPHENYLMETHANE Hexabalm Acigena 3,3',4,4',6,6'-hexachloro-2,2'-methylenediphenol 2,2'-methylenebis(3,4,6-trichlorophenol) 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane 毒菌酚 ######## NCI-C02653 B 32 {uni_hambur 六氯芬 2,2'-DIHYDROXY-3,5,6,3',5',6'-HEXACHLORODIPHENYL METHANE 2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane Hexafen Hexachlorofen Septofen 2,2'-dihydroxy-3,3',5,5',6,6'-hexachlo Ritosept Hexo AT-17 Fesia-sin Phenol, 2,2' 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane Exofene Hexosan {uni 3,3',5,5',6,6'-HEXACHLORO-2,2'-DIHYDROXYDIPHENYLMETHANE BIS-(3,4,6-T AT-7 Methane, bis(2,3,5-trichloro-6-hydroxyphenyl) Septisol 2,2'-Methylenebis[3,4,6-trichlorophenol] Fostril 2,2′-亚甲基双(3,4,6-三氯苯酚) hexachlorophene G 11 甲双三氯酚 雙(3,5,6-三氯-2-羥苯)甲烷 Fomac Gamophen G 11 (bactericide) S 2,2'-Methylen-bis-(3,4,6-trichlorphenol) hexachlorophene (INN) Steraskin Germa-Medica {Che
Beilstein Registry Number2064407
EC Number200-733-8
MDL NumberMFCD00002171
PubChem Substance ID3598
Chemical Name Translation六氯酚
Merck Number4680
Wiswesser Line NotationQR BG DG EG F1R BQ CG EG FG
InChIInChI=1S/C13H6Cl6O2/c14-6-2-8(16)12(20)4(10(6)18)1-5-11(19)7(15)3-9(17)13(5)21/h2-3,20-21H,1H2
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分类

  • {SNA} Analytical Standards, Food and Cosmetic Component Standards, H-M, Other, Standards for Personal Care and Cosmetic Products, neats, prohibited substances (EU-REGULATION No 1223/2009), 农残和代谢标准品, 分析/色谱, 按照字母排序
  • {SNA} Analytical Standards, Food and Cosmetic Component Standards, H-M, Other, Standards for Personal Care and Cosmetic Products, neats,
  • {SNA} All alphabetically sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, H, H-M, HA -HT,

产品应用

  • 六氯酚对革兰氏阳性菌特别有效,而对革半氏阴性菌效力差,对高酸菌、霉菌及牙胞杆菌、病毒、螺旋体等无效。石炭酸系数为125。该品曾大量用于痱子、襁褓斑疹、面疱的治疗药及婴儿扑粉、药皂等。对氯酚对皮肤几乎没有刺激作用。

相关文献及参考

  • Gaines, T.B. and Linder, R.E.: Fundam. Appl. Toxicol., 7, 299 (1986)
  • Short: III/20b
  • Short: EINECS
  • Merck: 14,4680 Beilstein: 6,IV,6659
  • Merck: 14,4680
  • Short: IV/8A

安全信息

Precautionary statements
  • P301+P310
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
GHS Symbol
WGK Germany3
Signal word Danger
Hazard statements
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H301 Toxic if swallowed 吞食有毒
  • H301+H311
Hazard Codes T,N,F T,N T;N
RTECSSM0700000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Safety Statements
  • S37 Wear suitable gloves 戴适当手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
Risk Statements
  • R24/25 Toxic in contact with skin and if swallowed 皮肤接触及吞食都有毒
  • R11 Highly flammable 非常易燃
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
  • R52/53
  • R50/53
UN Number 2875 UN 2875 6.1/PG 3
Packing GroupIII
Hazard Class6.1(b)
Storage condition 2-8°C
Warnings 危化品目录(2015) 危险化学品
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 33500 ug/m3/52W
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 33(1),62,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8400 mg/kg/21W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   19,413,1959

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - infant
DOSE/DURATION           : 257 mg/kg/7D-I
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Gastrointestinal - hypermotility, diarrhea
   Vascular - shock
REFERENCE :
   AJDCAI American Journal of Diseases of Children.  (AMA, 535 N. Dearborn St.,
   Chicago, IL 60610) V.1-80(3), 1911-50; V.100-    1960-
   Volume(issue)/page/year: 1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(10),26,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 8500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JSCCA5 Journal of the Society of Cosmetic Chemists.  (Soc. of Cosmetic
   Chemists, 1995 Broadway, Suite 1701, New York, NY 10023)  V.1-    1947-
   Volume(issue)/page/year: 20,173,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 8-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   28,43,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 300 mg/kg
SEX/DURATION            : female 8-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   AEHLAU Archives of Environmental Health.  (Heldref Pub., 4000 Albemarle St.,
   NW, Washington, DC 20016)  V.1-    1960-  Volume(issue)/page/year:
   28,43,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 435 mg/kg
SEX/DURATION            : female 15-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
   per # born alive)
   Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
   alive at weaning per # alive at day 4)
REFERENCE :
   FCTXAV Food and Cosmetics

其他信息

  • MSDS 信息:双(3,5,6-三氯-2-羟基苯)甲烷(70-30-4).msds
  • 灭火剂:砂土、干粉、泡沫
  • 外观性质:白色或浅褐色粉末。
  • 上游原料:发烟硫酸 --> 连二亚硫酸钠 --> 多聚甲醛 --> 二氯乙烷 --> 2,4,5-三氯苯酚 --> 脱色炭
  • 类别:农药
  • 毒性分级:高毒
  • MOL 文件:70-30-4.mol
  • color:off-white to tan
  • 刺激数据:皮肤-兔子 0.03 毫克 轻度; 眼睛-兔子 1500 毫克/24小时 中度
  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 用途一:六氯酚对革兰氏阳性菌特别有效,而对革半氏阴性菌效力差,对高酸菌、霉菌及牙胞杆菌、病毒、螺旋体等无效。石炭酸系数为125。该品曾大量用于痱子、襁褓斑疹、面疱的治疗药及婴儿扑粉、药皂等。对氯酚对皮肤几乎没有刺激作用。
  • 不溶于水,溶于醇、醚、丙酮、氯仿、丙二醇、聚乙二醇、橄榄油、棉子油和稀碱液。无气味或微带苯酚气味。
  • 可燃性危险特性:可燃; 受热分解有毒氯化物气体
  • Sigma Aldrich:70-30-4(sigmaaldrich)
  • 方法一:由2,4,5-三氯酚与甲醛或聚甲醛反应而得。将三氯酚、聚甲醛和硫酸搅拌混合,升温至75℃,反应液由稀薄变得稠厚,又立即由稠厚变为稀薄,将反应液倒入大量冰水中。过滤,滤饼用热水洗至中性,用稀碱溶解后加热至90℃,加入保险粉和活性炭,脱色30min。过滤,滤液加盐酸调节pH至2-3,冷至50℃以下,甩滤,滤饼用水洗涤,于80℃干燥,得六氯酚粗品。粗品经重结晶、精制即得成品。收率66%。另一种操作方法是使反应在溶剂二氯乙烷中进行,即将70g三氯酚、125ml二氯乙烷和32g20%发烟硫酸混合,加热至70-88℃,在1h内边搅拌边加入5.8g聚甲醛。全部加完后,回流1.5h,慢慢加入125ml二氯乙烷。停止搅拌,从底部将重硫酸层分离,用62ml二氯乙烷分两次提取硫酸层。将提取液与反应液分出的二氯乙烷层合并,加3g脱色炭脱色,然后在80℃过滤,加125ml水后,用水蒸汽蒸馏,将馏出物中悬浮的生成物滤出,干燥,得67.5-70g六氯酚。
  • TCI Shanghai:2,2’-亚甲基双(3,4,6-三氯苯酚) Hexachlorophene,>;98.0%(T)(70-30-4)
  • 急性毒性:口服-大鼠 LD50: 56 毫克/公斤; 口服-小鼠 LD50: 67 毫克/公斤
  • 六氯芬价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 M0219 六氯酚 Hexachlorophene 25G 835元

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