(-)-Pseudoephedrine (1R,2R)-(-)-伪麻黄碱

CAS 321-97-1 MFCD00002203

化学结构图

321-97-1
SMILES: CN[C@H](C)[C@H](O)c1ccccc1

化学属性

Mol. FormulaC6H5CH[CH(NHCH3)CH3]OH
Mol. Weight165.23
Melting Point118-120 °C(lit.)

别名和识别编码

Chemical Name(1R,2R)-(-)-Pseudoephedrine
Synonym R,R(-)-PSEUDOEPHEDRINE (1r,2r)-ephedrine CPDD 0049 (1R,2R)-Ephedrine 伪麻黄碱(无法供) [R-(R*,R*)]-alpha-[1-(methylamino)ethyl]benzyl alcohol (1R,2R)-(-)-伪麻黄碱 Benzenemethanol, α-[(1R)-1-(methylamino)ethyl]-, (αR)- (-)-Pseudoephedrine 右旋麻黄碱 (1R,2R)-2-(METHYLAMINO)-1-PHENYLPROPAN-1-OL (IR,2R)-1-Pseudephedrine Base 伪麻黄碱 l-Pseudoephedrine base 右旋伪麻黄碱 (1R,2R)-(-)-PSEUDOEPHEDRINE (1S,2S)-2-甲氨基-1-苯基丙-1-醇 (1r,2r)-(-)-2-(methylamino)-1-phenylpropanol l-(1R,2R)-Pseudoephedrine l-Pseudoephedrine (1R,2R)-2-METHYLAMINO-1-PHENYL-1-PROPANOL Benzenemethanol, alpha-(1-(methylamino)ethyl)-, (R-(R*,R*))- alpha-(1-(methylamino)ethyl)-,(r-(r*,r*))-benzenemethano (-)-y-Ephedrine (-)-threo-Ephedrine (1R,2R)-(-)-Pseudoephedrine; (1R,2R)-(-)-2-(Methylamino)-1-phenylpropanol; alpha-(1-Methylaminoethyl)benzyl alcohol 假麻黄碱 Benzenemethanol, α-[1-(methylamino)ethyl]-, [R-(R*,R*)]- D-Pseudoephedrine α-(1-甲氨基乙基)苄醇 (-)-ψ-麻黄碱 (-)-伪麻黄碱 (1R,2R)-(-)-2-(甲氨基)-1-苯丙醇 l-伪麻黄碱 (αR)-α-[(1R)-1-(methylamino)ethyl]benzenemethanol 左旋伪麻黄碱 (-)-PSI-EPHEDRINE (-)-PSEUDOEPHEDRINE R,R(-PSEUDOEPHEDRINE,1.0MG/MLINMETHANOL
PubChem Substance ID62946
EC Number206-292-8
Beilstein Registry Number2803417
MDL NumberMFCD00002203
CAS Number321-97-1
Chemical Name Translation(1R,2R)-(-)-伪麻黄碱
InChIKeyKWGRBVOPPLSCSI-SCZZXKLOSA-N
InChIInChI=1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m1/s1
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分类

  • {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb), 细胞生物学, 营养研究
  • {SA} Alphabetic, Analytical Standards, Analytical/Chromatography, P, PON - PT
  • {SNA} Alkaloid, Asymmetric Synthesis, Chemical Synthesis, Chiral Auxiliaries, Ephedra sinica, Ephedrine Derivatives, Nutrition Research, Phytochemicals by Chemical Classification, Phytochemicals by Plant (Food/Spice/Herb)

相关文献及参考

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
RTECSUL5750500
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P317
  • P301+P330+P331
  • P302+P352
  • P302+P361+P354
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P316
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P333+P313
  • P337+P317
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Warning
Hazard Codes Xn
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition Refrigerator (+4°C)
Restrict 易制毒化学品
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 148,158,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 248 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPMSAE Journal of Pharmaceutical Sciences.  (American Pharmaceutical Assoc.,
   2215 Constitution Ave., NW, Washington, DC 20037)  V.50-    1961-
   Volume(issue)/page/year: 53,987,1964

其他信息

  • 比旋光度:-51 ° (c=0.6, EtOH)
  • MSDS 信息:(1R,2R)-(-)-Pseudoephedrine(321-97-1).msds
  • 左旋伪麻黄碱价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 258860050 左旋伪麻黄碱 (1R,2R)-(-)-Pseudoephedrine 98% 5 GR 627元
  • MOL 文件:321-97-1.mol
  • Sigma Aldrich:321-97-1(sigmaaldrich)
  • 用途一:呼吸系统用药。
  • Acros Organics:伪麻黄碱(无法供) (1R,2R)-(-)-Pseudoephedrine,98%(321-97-1)

系列性分类


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