4-Chloro-3-Methylphenol 4-氯-3-甲基苯酚

CAS 59-50-7 MFCD00002323

化学结构图

59-50-7
SMILES: Cc1cc(O)ccc1Cl

化学属性

Mol. FormulaC7H7ClO
Mol. Weight143
Density1.37
Flash Point118°(244°F)
TSCAYes
Melting Point63-65
Boiling Point235
Solubility不溶于水,易溶于多数有机溶剂。

别名和识别编码

Chemical Name4-Chloro-3-Methylphenol
Synonym 1-Chloro-2-methyl-4-hydroxybenzene 2-CHLORO-5-HYDROXYTOLUEN 2-Chloro-5-hydroxytoluene 3-Methyl-4-chlorophenol 4-CHLORO-3-CRESOL 4-CMC 4-Chloro-m-cresol 4-Chloro-m-cresol 4-chloro-3-methyl-phenol 4-chloro-m-creso 4-氯(代)-3-甲基(苯)酚 4-氯-3-甲酚 m-Cresol, 4-chloro- p-Chlor-m-cresol p-Chloro-m-cresol Aptal CHLORO(4-)-3-METHYLPHENOL Chlorocres Chlorophenol, 4-, methyl, 3- Neopredisan Ottafact P-氯-M-甲酚 PARA CHLORO META CRESOL PCMC Parol Raschit Rasen-Anicon ai3-00075 p {} {} {Chemicalbook} {} {} {uni_ha 对氯间甲酚,4-氯间甲酚
MDL NumberMFCD00002323
CAS Number59-50-7
EC Number200-431-6
Merck Number2133
Beilstein Registry Number1237629
PubChem Substance ID87565327
Reaxys-RN1237629
Chemical Name Translation4-氯-3-甲基苯酚
Wiswesser Line NotationQR DG C
LabNetwork Molecule IDLN00221861
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分类

  • {SNA} 2000/60/EC, Alphabetical Index of Analytical Standards, Method and Regulation Specific, Alpha Sort, Analytical Standards, Analytical/Chromatography, C, CH, Chromatography, Environmental Standards, European Community: ISO, DIN and DL 152, Volatiles/ Semivolatiles
  • {SNA} Building Blocks,

产品应用

  • 用于有机合成,如染料、影片防腐剂等。

相关文献及参考

  • Merck:14,2133 Beilstein: 6,IV,2064
  • Short: III/35D2
  • Short: III/20b
  • Merck:14,2133

安全信息

RTECSGO7100000
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S7 Keep container tightly closed 保存在严格密闭容器中;
Packing GroupIII
UN Number 2669/3077 3077 3437 UN 3077 9/PG 3 UN3437
Risk Statements
  • R21/22 Harmful in contact with skin and if swallowed 皮肤接触和不慎吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
  • R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
  • R50 Very toxic to aquatic organisms 对水生生物极毒
GHS Symbol
WGK Germany2
Hazard statements
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H302+H312
  • H318 Causes serious eye damage 严重伤害眼睛
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P301+P330+P331+P310
  • P302+P350
  • P305+P351+P338
  • P305+P351+P338+P310
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes 9
Hazard Class6.1
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(issue)/page/year: 36(1-4),10,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - tremor
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   12,212,1939

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1830 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SchP## Personal Communication from P. Schmitz, Bayer AG, 5090 Leverkusen,
   Bayerwerk, Fed. Rep. Ger., April 4, 1986  Volume(issue)/page/year: 04APR1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   QJPPAL Quarterly Journal of Pharmacy & Pharmacology.  (London, UK)  V.2-21,
   1929-48.  For publisher information, see JPPMAB.  Volume(issue)/page/year:
   12,212,1939

TYPE OF TEST            :

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 307,141,1994

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 25 ug/plate
REFERENCE :
   TECSDY Toxicological and Environmental Chemistry.  (Gordon & Breach Science
   Pub. Inc., 1 Park Ave., New York, NY 10016)  V.3(3/4)-    1981-
   Volume(issue)/page/year: 14,143,1987

Restrict 危险品

其他信息

  • 酚类单一化合物标准液
  • Acros Organics:4-氯-3-甲基苯酚 4-Chloro-3-methylphenol, 99+%(59-50-7)
  • Sigma Aldrich:59-50-7(sigmaaldrich)
  • MSDS 信息:4-氯-3-甲酚(59-50-7).msds
  • 20℃时1g能溶于250ml水,在热水中溶解更多,易溶于苯、乙醚、乙醇、丙酮、氯仿和石油醚。能随水蒸气挥发。
  • 毒性分级:中毒
  • Alfa Aesar:4-氯-3-甲基苯酚,99% 4-Chloro-3-methylphenol, 99%(59-50-7)
  • 急性毒性:口服-大鼠 LD50: 1830 毫克/公斤; 口服-小鼠 LD50: 600 毫克/公斤
  • 上游原料:磺酰氯 --> 间甲酚 --> 干燥剂
  • 用途一:用于有机合成,如染料、影片防腐剂等。
  • 储运特性:库房通风低温干燥; 与氢氧化钠分开储运
  • 图谱信息:4-氯-3-甲酚(59-50-7)红外图谱(IR1)
  • 外观性质:无色结晶,带有苯酚气味。
  • 可燃性危险特性:受热放出有毒氯化物, 光气烟雾
  • 灭火剂:二氧化碳、砂土、泡沫、干粉
  • 海关编码:29081000
  • TCI Shanghai:间甲基对氯苯酚(区域精制法精制,熔段数:26) 4-Chloro-m-cresol Zone Refined (number of passes:26)(59-50-7)
  • MOL 文件:59-50-7.mol
  • 4-氯-3-甲酚价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw090001 棕榈酸异丙酯 25ml 120元 2011/08/23 xw090004 棕榈酸异丙酯 100ml 150元 2011/04/16 C0628 4-氯间甲酚l(区域精制法精制,熔段数:26) 4-Chloro-m-cresol Zone Refined (number of passes:26) 1SAMPLE 966元
  • 方法一:由间甲酚与二氯硫酰反应。在搅拌下,将间甲酚慢慢加入二氯硫酰,反应温度控制在30-50℃。加完后保温16h,用水洗,用碳酸钠溶液洗至碱性,再用热水洗至中性。分出油层用无水氯化钙干燥,滤去干燥剂后减压蒸馏,将蒸馏液倒入石油醚中,冷却,过滤,干燥得成品。
  • 类别:有毒物品

系列性分类


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