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• 试剂商城
• 直接询价

分类

• {SNA} A to C, A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Carbonic anhydrase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, 细胞生物学
• {SNA} A to C, Carbonic anhydrase, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, 生化试剂, 酶、抑制剂和底物
• {SA} A to C, A-AM, Bioactive Small Molecules, Biochemicals and Reagents, Carbonic anhydrase, Cell Biology, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates

相关文献及参考

• [2]. Bayat Mokhtari R, et al. Acetazolamide potentiates the anti-tumor potential of HDACi, MS-275, in neuroblastoma. BMC Cancer. 2017 Feb 24;17(1):156.
• [3]. Gao H, et al. Combined treatment with acetazolamide and cisplatin enhances chemosensitivity in laryngeal carcinoma Hep-2 cells. Oncol Lett. 2018 Jun;15(6):9299-9306.
• [4]. Kassamali R, et al. Acetazolamide: a forgotten diuretic agent. Cardiol Rev. 2011 Nov-Dec;19(6):276-8.
• 1. Gao, J., et al., Acetazolamide inhibits osmotic water permeability by interaction with aquaporin-1 Anal. Biochem. 350 , 165-170, (2006) 摘要
• 2. Tanimura, Y., et al., Acetazolamide reversibly inhibits water conduction by aquaporin-4 J. Struct. Biol. 166 , 16-21, (2009) 摘要
• Bazzu, G., et al., Real-time Monitoring Of Brain Tissue Oxygen Using A Miniaturized Biotelemetric Device Implanted In Freely Moving Rats. Anal. Chem. 81 , 2235-41, (2009) 摘要
• Hauge, A., et al., Acute effects of acetazolamide on cere

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ABMGAJ Acta Biologica et Medica Germanica.  (Berlin, Ger. Dem. Rep.) V.1-41,
   1958-82.  For publisher information, see BBIADT. Volume(issue)/page/year:
   21,193,1968

TYPE OF TEST            : TDLo - Low

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 39,255,1976

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   56(4),134S,1960

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,15,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 300 mg/kg
SEX/DURATION            : female 9-10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 29,427,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6600 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JHMJAX Johns Hopkins Medical Journal.  (Baltimore, MD)  V.120-151, 1967-82.
   Discontinued.  Volume(issue)/page/year: 130,105,1972

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 5-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Effects on Newborn - sex ratio
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 34,452,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Rep

其他信息

• 灭火剂:干粉、泡沫、砂土和水
• 用途一:该品为利尿药。为碳酸酐酶抑制剂，服后抑制肾小管上皮细胞中的碳酸酐酶，使H2CO3的形成减少，H+的产生随之下降。因此，H+与Na+的交换大为减慢，结果HCO3-，Na+，K+排出增加，尿量增多。该品尚能抑制房水分泌过程，使眼压下降。用于治疗青光眼，轻度心脏性水肿等。
• 储运特性:库房通风低温干燥
• 毒性分级:中毒
• 上游原料:乙酰氯 --> 磺酰氯 --> 焦亚硫酸钠 --> 硫氰酸铵 --> 2-乙酰氨基-5-巯基-1,3,4-噻二唑
• Sigma Aldrich:59-66-5(sigmaaldrich)
• MOL 文件:59-66-5.mol
• 图谱信息:乙酰唑胺(59-66-5)红外图谱(IR1) 乙酰唑胺(59-66-5)红外图谱(IR2)
• 急性毒性:腹腔-大鼠LD50:2750毫克/公斤;口服-小鼠 LD50: 4300 毫克/公斤
• 乙酰唑胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 U1005004 乙酰唑胺 2g 1990元 2010/05/25 L07562 乙酰唑胺, 99% Acetazolamide, 99% 5g 209元 2010/05/25 L07562 乙酰唑胺, 99% Acetazolamide, 99% 25g 582元
• Alfa Aesar:乙酰唑胺,99% Acetazolamide, 99%(59-66-5)
• 可燃性危险特性:可燃;加热分解释放极毒氮氧化物, 硫氧化物烟雾
• 方法一:1.氯化、氧化2-乙酰氨基-5-巯基-1,3,4-噻二唑加入冰醋酸及水混合液中，冷却至-2℃通氯，终温不超过5℃。当物料温度显著下降，液面有大量泡沫出现，液氯耗用至规定量时停止通氯，过滤，滤饼用冰水洗涤至pH为4，得氯氧化物（2-乙酰氯基-5-磺酰氯-1,3,4-噻二唑）。2.胺化 将氨水与碎冰混合，降温至5℃以下。加入氯氧化物，加毕，保温反应半小时。用盐酸调节pH至5-6，过滤，滤饼洗涤至pH为7，干燥，得乙酰唑胺粗品。将粗品、水、活性炭及偏重亚硫酸钠加热至95℃，脱色1-1.5h，趁热过滤，滤液冷却结晶，过滤，洗涤，干燥，得乙酰唑胺。
• MSDS 信息:2-Acetamido-5-sulfamoyl-1,3,4-thiadiazole(59-66-5).msds
• 类别:有毒物品