2-((5-Nitrofuran-2-yl)methylene)hydrazine-1-carboxamide 2-(5-硝基呋喃-2-基)亚甲基)肼-1-甲酰胺

CAS 59-87-0 MFCD00003225

化学结构图

59-87-0
SMILES: NC(=O)NN=Cc1ccc([N+](=O)[O-])o1

化学属性

Mol. FormulaC6H6N4O4
Mol. Weight198
Melting Point242-244
TSCAYes
Solubility<0.1 G/100 ML AT 19 ºC
Flash Point2 °C
Appearance 黄色结晶性粉末。熔点236-240℃（分解）。1份该品可溶于4200份水、590份乙醇，几乎不溶于乙醚、氯仿。饱和溶液的pH为6.0-6.5。无臭，味苦。日光下色渐变深。
Density1.7
Stability对光线敏感

别名和识别编码

Chemical Name2-((5-Nitrofuran-2-yl)methylene)hydrazine-1-carboxamide
CAS Number59-87-0
Synonym ######## (5-Nitro-2-furfurylideneamino)urea 2((5-Nitro-2-fu 2-((5-nitro- 2-Furancarboxaldehyde, 5-n 5-NITRO-2-FURALDEHYDE SEMICARB 5-NITRO-2-FURFURYLIDENE SEMICARBAZONE 5-Nitrofurfural semicarbazone 5-Nitrofurfurolsemicarbazon Amifur Cocafurin Coxistat Dermofural Furaci Furacilin Furacilinum Furacycline Furan-ofteno Furosem Hemofuran Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]- LABOTEST-BB LT00134617 Mammex Monafuracin NCI-C56064 NFS NSC-2100 Nfz mix Nitrofuraldehyde semi Nitrofuran Nitrofurazan Nitrofurazone USAF
MDL NumberMFCD00003225
PubChem Substance ID87573571
Beilstein Registry Number86403
EC Number200-443-1
Reaxys-RN86403
Merck Number6600
Chemical Name Translation2-(5-硝基呋喃-2-基)亚甲基)肼-1-甲酰胺
Wiswesser Line NotationT5OJ BNW E1UNMVZ
InChIInChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+
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分类

  • {uni_hamburg} no charge; oxygen heterocycle; aromatic; 5ring; urea; 1fragment
  • {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Drugs & Metabolites, Forensic and Veterinary Standards, Neat Compounds
  • {SA} Building Blocks, C4 to C7, Chemical Synthesis, Furans, Heterocyclic Building Blocks
  • Heterocycles
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standard

产品应用

  • 该品味硝基呋喃类抗菌药。这类药物还包括呋喃唑酮、呋喃妥因。呋喃西林口服毒性大，用于外科局部或表面消毒。

相关文献及参考

  • Merck:14,6600 Beilstein: 17,V,9,335
  • Short: EINECS
  • Short: III/5a
  • Morris, et al.: Cancer Res., 29, 2145 (1969),
  • Merck:14,6600

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P305+P351+P338
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H312 Harmful in contact with skin 皮肤接触有害
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
Hazard Codes Xn F,Xn Xn,F
RTECSLT7700000
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Signal word Danger Warning
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Risk Statements
  • R11 Highly flammable 非常易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36 Irritating to eyes 刺激眼睛
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R62 Possible risk of impaired fertility 有削弱生殖能力的危险
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
Storage condition Light Sensitive 2-8°C
Packing GroupIII
Hazard Class6.1(b)
UN Number 3249 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31 gm/kg/45W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Skin and Appendages - tumors
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 25,419,1966

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10094 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 25,419,1966

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11176 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   27,129,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8652 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-337,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 249 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
   (Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
   London W1N 4EY, UK)  V.14-    1920-  Volume(issue)/page/year: 74,43,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 753 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 102,185,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 10,530,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 590 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   133,299,1947

{hazard_

{haz

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 ug/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-337,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 250 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,781,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 umol/L/90M (Continuous)
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   40,94,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   BJCSB5 British Journal of Cancer, Supplement.  (Macmillan Press Ltd.,
   Houndmills, Basingstoke, Hants. RG21 2ZS, UK)  No.1-    1973-
   Volume(issue)/page/year: 3,124,1978

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,3,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 40 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 175,149,1986

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : male 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   APJAAG Acta Pathologica Japonica.  (Japan Publications Trading Co., Ltd.,
   POB 5030, Tokyo International, Tokyo 101-31, Japan)  V.1-    1951-
   Volume(issue)/page/year: 14,261,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1792 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 840 mg/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   53,585,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 900 mg/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Developm

其他信息

  • 可燃性危险特性:可燃, 火场排出氮氧化物辛辣刺激烟雾
  • 用途一:硝基呋喃类抗菌药，主要用于家禽、家畜及水产鱼类的防病、抗菌
  • Sigma Aldrich:59-87-0(sigmaaldrich)
  • 急性毒性:口服- 大鼠 LD50 590 毫克/ 公斤; 口服- 小鼠 LD50: 249 毫克/公斤
  • 毒性分级:高毒
  • TCI Shanghai:5-硝基-2-呋喃醛缩氨基脲 Nitrofurazone,>;98.0%(LC)(E)(59-87-0)
  • 用途三:该品味硝基呋喃类抗菌药。这类药物还包括呋喃唑酮、呋喃妥因。呋喃西林口服毒性大，用于外科局部或表面消毒。
  • F:8
  • 图谱信息:呋喃西林(59-87-0)红外图谱(IR2) 呋喃西林(59-87-0)红外图谱(IR1) 呋喃西林(59-87-0)质谱(MS)
  • 呋喃西林价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0200 呋喃西林 Nitrofurazone 25G 95元 2014/06/02 N0200 呋喃西林 Nitrofurazone 250G 570元 2010/05/25 A18593 5-硝基-2-亚糠基半卡巴腙, 98+% 5-Nitro-2-furaldehyde semicarbazone, 98+% 250g 818元
  • 1份该品可溶于4200份水、590份乙醇，几乎不溶于乙醚、氯仿。饱和溶液的ph为6.0-6.5。无臭、味苦。日光下色渐变深。
  • 储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
  • Alfa Aesar:5-硝基-2-亚糠基半卡巴腙,98+% 5-Nitro-2-furaldehyde semicarbazone, 98+%(59-87-0)
  • 灭火剂:水, 二氧化碳, 干粉, 砂土
  • MSDS 信息:Furacilin(59-87-0).msds
  • MOL 文件:59-87-0.mol
  • 方法一:由糠醛经硝化、酯化、水解，制得5-硝基糠醛，再与盐酸氨基缩合而得呋喃西林。
  • 类别:有毒物品
  • 上游原料:乙酐 --> 尿素 --> 水合肼 --> 5-硝基糠醛
  • 用途二:该品为硝基呋喃类抗菌药。这类药物还包括呋喃唑酮、呋喃妥因。呋喃西林口服毒性大，用于外科局部或表面消毒。
  • 敏感性:Light Sensitive

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs &amp; Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs &amp; Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Furans 呋喃
  5. C4 to C7 - Furans

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