Prednisone 泼尼松

CAS 53-03-2 MFCD00003608

化学结构图

53-03-2
SMILES: C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]1CC[C@]2(O)C(=O)CO

化学属性

Mol. FormulaC21H26O5
Mol. Weight358.43
Melting Point236-238
Appearance 25 +172°(二噁烷),本品乙酸溶液在240nm波长处有最大吸收。 白色或类白色结晶性粉末,无气味,味微苦。几乎不溶于水,微溶于乙醇(1:190)和氯仿(1:200)。Mp233-235℃(分解),比旋光度[α] D
Refractive index170 ° (C=0.5, Dioxane)
Density1.3
Stability对光敏感
SolubilityDMSO 72 mg/mL (200 mM); Water <1 mg/mL (<1 mM),

别名和识别编码

Chemical NamePrednisone
CAS Number53-03-2
Alfabeta NameDIHYDROXYPREGNADIENETRIONE 17211431120-----,,,,
MDL NumberMFCD00003608
Synonym (8S,9S,10R,13S,14S,17R)-17-HYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-7,8,9,10,12,13,14,15,16,17-DECAHYDRO-6H-CYCLOPENTA[A]PHENANTHRENE-3,11-DIONE 1 1,4-PREGNADIEN-17,21-DIOL-3,11,20-TRIONE 1,4-PREGNADIEN-17ALPHA,21-DIOL-3,11,20-TRIONE 1,4-PREGNADIENE-17ALPHA,21-DIOL-3,11,20-TRIONE 1,4-Pregnadiene-17,21-diol-3,11,20-trione, 1-Cortisone, 17,21-Dihydroxy-1,4-pregnadiene-3,11,20-trione, Dehydrocortisone 1,4-Pregnadiene-17a,21-diol-3,11,20-trione; 17,21-Dihydroxypregna-1,4-diene-3,11,20-trione 1,4-pregnadiene-16-alpha,21-diol-3,11,20-trione 1-CORTISONE 1-DEHYDROCORTISONE 11,20-trione,17,21-dihydroxy-pregna-4-diene-3 11,20-trione,17,21-hydroxy-pregna-4-diene-3 17,21-Dihydroxypregna-1,4-diene-3,11 170,21-二羟基-Δ1,4-孕甾二烯-3,11,20-三酮,17Α,21-DIHYDROXY-1,4-PREGNADIENE-3,11,20-TRIONE Acsi
Beilstein Registry Number2065301
EC Number200-160-3
PubChem Substance ID5865
Chemical Name Translation泼尼松
Merck Number7722
Wiswesser Line NotationL E5 B666 CV OV AHTTT&J A1 E1 FV1Q FQ
LabNetwork Molecule IDLN00009241
InChIInChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, P, Steroid Hormones

产品应用

  • Downregulates TNF-α production and NF-κB expression

相关文献及参考

  • [2]. Zhang H, et al. Prednisone adding to usual care treatment for refractory decompensated congestive heart failure. Int Heart J. 2008 Sep;49(5):587-95.
  • Lennon, V., et al.: Lancet, 364, 2106
  • Merck:7722 Beilstein: 8,IV,3531
  • [1]. RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1(4):488-96.
  • [1]. RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1(4):488-96.
  • [2]. Zhang H, et al. Prednisone adding to usual care treatment for refractory decompensated congestive heart failure. Int Heart J. 2008 Sep;49(5):587-95.

安全信息

Warnings IRRITANT
GHS Symbol
WGK Germany3
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P308+P313
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
RTECSTU4154100
Signal word
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes Xn
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Storage condition 密封保存 储存温度-20°C
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 860 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - tumors
   Skin and Appendages - tumors
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 40,1935,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 400 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   IJMSAT Irish Journal of Medical Science.  (Royal Academy of Medicine, 6
   Kildare St., Dublin 2, Ireland)  1922-67; Ser. 7: V.1-    1968-
   Volume(issue)/page/year: 155,234,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 113 mg/kg
TOXIC EFFECTS :
   Blood - hemorrhage
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   243,1260,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 2400 ug/kg/2D-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - sensory change involving peripheral nerve
REFERENCE :
   NEURAI Neurology.  (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN
   55802)  V.1-    1951-  Volum

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3333 ug/plate
REFERENCE :
   NTPTB* NTP Technical Bulletin.  (National Toxicology Program, Landow Bldg.
   3A-06, 7910 Woodmont Ave., Bethesda, MD 20205)  Volume(issue)/page/year:
   JAN1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 333 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 24 mg/kg
SEX/DURATION            : female 13-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - behavioral
REFERENCE :
   PBBHAU Pharmacology, Biochemistry and Behavior.  (ANKHO International Inc.,
   P.O. Box 426, Fayetteville, NY 13066)  V.1-    1973-
   Volume(issue)/page/year: 12,213,1980

其他信息

  • MOL 文件:53-03-2.mol
  • 图谱信息:泼尼松(53-03-2)质谱(MS) 泼尼松(53-03-2)红外图谱(IR2) 泼尼松(53-03-2)红外图谱(IR1)
  • Sigma Aldrich:53-03-2(sigmaaldrich)
  • 方法一:以醋酸可的松或醋酸二氢可的松为原料,用二氧化硒脱氢,再水解制得。
  • 用途一:生化研究;肾上腺皮质激素类药物,具有抗炎、抗过敏等作用。
  • 用途二:常用于联合化疗中,可改善病人一般情况,还可用于急性白血病及其他肿瘤等。
  • 上游原料:二氧化硒 --> 氢化可的松 --> 醋酸可的松
  • 比旋光度:169 ° (c=0.5, dioxane)
  • Prednisone 是一种人工合成的皮质类固醇剂,是特别有效的免疫抑制剂的化合物。
  • MSDS 信息:1,4-Pregnadiene-17a,21-diol-3,11,20-trione(53-03-2).msds
  • 下游产品:11Β,17Α-二羟基-1,4-孕二烯-3,20-二酮17-丙酸酯

系列性分类


相关产品推荐