Testosterone Propionate 丙酸睾酮

CAS 57-85-2 MFCD00003653

化学结构图

57-85-2
SMILES: CCC(=O)OC1CCC2C3CCC4=CC(=O)CCC4(C)C3CCC12C

化学属性

Mol. FormulaC22H32O3
Mol. Weight344.54
Melting Point118-122°C
SolubilityThis product is soluble in chloroform (50 mg/ml).
Appearance solid
Stability光敏感性固体
Density1.1

别名和识别编码

Chemical NameTestosterone propionate
CAS Number57-85-2
Synonym 17β-Propionyloxy-4-androsten-3-one 17-(1-oxopropoxy)-(17b)-androst-4-en-3-one 17BETA-HYDROXY-4-ANDROSTEN-3-ONE 17-PROPIONATE 17BETA-PROPIONYLOXY-4-ANDROSTEN-3-ONE 17β-(Propionyloxy)androst-4-en-3-one 17β-Hydroxy-4-androsten-3-one 17-propionate 17β-Hydroxyandrost-4-en-3-one-17β-propionate 17β-propionyloxy-androst-4-en-3-one 17丙酸睾丸激素 3-Oxoandrost-4-en-17-yl propionate 4-ANDROSTEN-17BETA-OL-3-ONE 17-PROPIONATE Agovirin Androlon Andronate Androst-4-en-3-one, 17-(1-oxopropoxy)-(17-beta)- Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17beta)- Androst-4-en-3-one, 17-(1-oxopropoxy)-, (17β)- Androst-4-en-3-one, 17bet Anertan Aquaviron Bio-testiculina Eifelfango, Testosteron Pro
PubChem Substance ID5995
EC Number200-351-1
Beilstein Registry Number3221760
MDL NumberMFCD00003653
Chemical Name Translation丙酸睾酮
Merck Number9180
Wiswesser Line NotationL E5 B666 OV MUTJ A1 E1 FOV2 -B&AEF
InChIInChI=1S/C22H32O3/c1-4-20(24)25-19-8-7-17-16-6-5-14-13-15(23)9-11-21(14,2)18(16)10-12-22(17,19)3/h13,16-19H,4-12H2,1-3H3/t16-,17-,18-,19-,21-,22-/m0/s1
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分类

  • Androgen, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Lipids, Steroid Hormones, Steroids (C19) and Derivatives, Sterol Lipids, T
  • {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 13ring; 14ring; 17ring; ester; ketone; chiral; 1fragment
  • {SNA} Androgen, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Lipids, Steroid Hormones, Steroids (C19) and Derivatives, Sterol Li

产品应用

  • 用于治疗乳腺癌、卵巢癌、子宫肌瘤、多发性骨髓瘤及肾癌等。丙酸睾丸酮已被用于研究对怀孕母羊的影响作用

相关文献及参考

  • Short: III/5b
  • Merck:13,9255
  • Glass, A., et al.: J. Clin. Endocrinol. Metab., 45, 1211 (1977),
  • Short: EINECS
  • Merck:13,9255 Beilstein:8(3)897
  • Merck 14 ,9180

安全信息

GHS Symbol
WGK Germany3
Hazard Codes T
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H350 May cause cancer 可能致癌
  • H351 Suspected of causing cancer 怀疑致癌
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSXA3115000
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P203
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P312
  • P301+P317
  • P302+P352
  • P304+P312
  • P304+P340
  • P308+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P318
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
UN Number 2811
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Risk Statements
  • R45 May cause cancer 可能致癌
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 360 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Musculoskeletal - tumors
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   25,141,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JSONDX Journal of Soviet Oncology.  (New York, NY)  V.1-5, 1980-84.
   Volume(issue)/page/year: 5,396,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 432 mg/kg/48W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Reproductive - Tumorigenic effects - prostate tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   37,1929,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5200 mg/kg/65W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 192,1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,487,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).

{

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,487,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 970 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,487,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,487,1982

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Fish - not otherwise specified
DOSE/DURATION           : 500 ug
REFERENCE :
   BEXBBO Biochemistry and Experimental Biology.  (Padua, Italy)  V.10-16,
   1971/72-80.  Suspended.  Volume(issue)/page/year: 15,329,1980

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Fish - not otherwise specified
DOSE/DURATION           : 500 ug
REFERENCE :
   BEXBBO Biochemistry and Experimental Biology.  (Padua, Italy)  V.10-16,
   1971/72-80.  Suspended.  Volume(issue)/page/year: 15,329,1980

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 10 mg/kg
REFERENCE :
   AMTUA3 Acta Medica Turcica.  (Dr. Ayhan Okcuoglu, Cocuk Hastalikari Klinigi,
   c/o Ankara Univ., Tip Facultesi, Cebeci, Ankara, Turkey) V.1-10/11, 1948-58;
   New series: V.1-    1964-  Volume(issue)/page/year: 8,68,1971

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 1 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 16,1329,1995

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 300 umol/L
REFERENCE :
   SinJF# Personal Communication from J.F. Sina, Merck Institute for
   Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
   Volume(issue)/page/year: 26OCT1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 92 mg/kg
SEX/DURATION            : male 23 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   29,409,1941

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 mg/kg
SEX/DURATION            : female 10 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   ECJPAE Endocrinologia Japonica.  (Japan Pub. Trading Co., Ltd., POB 5030,
   Tokyo International, Tokyo, Japan)  V.1-    1954-  Volume(issue)/page/year:
   23,327,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6250 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
   JPHYA7 Journal of Physiology.  (Cambridge Univ. Press, 32 E. 57th St., New
   York, NY 10022) V.1-    1878-  Volume(issue)/page/year: 172,393,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1500 ug/kg
SEX/DURATION            : female 27-29 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - postpartum
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants p

其他信息

  • MSDS 信息:17-(1-Oxopropoxy)-(17b)-androst-4-en-3-one(57-85-2).msds
  • MOL 文件:57-85-2.mol
  • 外观性质:白色或淡黄色结晶性粉末。不溶于水,易溶于醇、醚、吡啶、植物油。熔点:118~122℃
  • color:white
  • 不溶于水,易溶于醇、醚、吡啶、植物油。
  • TCI Shanghai:丙酸睾酮酯 Testosterone Propionate,>;98.0%(GC)(E)(57-85-2)
  • 丙酸睾丸素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 T0028 丙酸睾酮酯 Testosterone Propionate 5G 857元 2011/04/16 T0028 丙酸睾酮酯 Testosterone Propionate 25G 2540元
  • 药理作用:丙酸睾丸素又称丙酸睾酮、丙酸睾丸酮,常温下为白色结晶或类白色结晶性粉末,无臭。不溶于水,易溶乙醇或乙醚,略溶于植物油,极易溶于氯仿。药理作用与甲睾酮相似,但作用较后者略强。因口服易被肝脏破坏,故口服无效。常肌注其油溶液,吸收缓慢,作用强而持久,可维持时间数日。丙酸睾丸素能促进男性器官及第二性征的发育,促进蛋白质合成及骨质形成,对抗雌激素,抑制子宫内膜生长及卵巢、垂体功能。用于无睾症、隐睾症、男性性腺机能减退症、妇科疾病如月经过多、子宫肌瘤、老年性骨质疏松及再生障碍性贫血等。 本品在体内先转化为5α-二氢睾酮 (5α-dihyrotesterone),以后再与细胞受体结合,进入细胞核,与染色质作用,激活RNA多聚酶,促进蛋白质合成和细胞代谢。此外,丙酸睾酮可通过红细胞生成素刺激红细胞的生成和分化。丙酸睾丸素口服虽可吸收,但在肝中会迅速破坏而失效,故一般采用肌内注射。肌内注射丙酸睾酮后,吸收较慢,其延效时间2~4日。在血中,98%的睾酮与性激素球蛋白结合,仅2%为游离状。半衰期为10~20min。睾酮在肝内灭活后,代谢产物为雄酮、异雄酮及原胆烷醇酮。它们90%是与葡萄醛酸及硫酸结合的形式从尿中排出。约6%非结合形式的产物是由胆汁排出,其中少部分仍可再吸收,形成肠肝循环。
  • Sigma Aldrich:57-85-2(sigmaaldrich)
  • 用途一:用于治疗乳腺癌、卵巢癌、子宫肌瘤、多发性骨髓瘤及肾癌等。

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