3-Methylcholanthrene 3-甲基胆蒽

CAS 56-49-5 MFCD00003704

化学结构图

56-49-5
SMILES:

化学属性

Mol. FormulaC21H16
Mol. Weight268
Boiling Point280 °C/80 mmHg(lit.)
Melting Point178-180 °C(lit.)
Density1.0
Flash Point-5 °C

别名和识别编码

Chemical Name3-Methylcholanthrene
CAS Number56-49-5
Synonym {uni_hamburg} cholanthrene, 3-methyl- 3-mch 3-MC 3-甲基胆蒽 Methylcholanthrene 3-甲基胆蒽 溶液 3-methylbenz(j)aceanthrene 3-methyl-cholanthrene 1,2-Dihydro-3-methylbenz(j)aceanthrylen 3-Methylcholanthrene-(20) 3-METHYLCHOLANTHRENE 20-Methylcholanthrene 3-meca MCA 1,2-Dihydro-3-methyl-benz[j]aceanthrylene 20-methylchlolanthrene 3-Methyl-cholanthren (20) 3-Methyl-1,2-dihydrobenzo[j]aceanthrylene 3-methylcholanthren 20-METHYLCHOLANTHRENE 1,2-dihydro-3-methyl-benz[j]aceanthrylen 1,2-dihydro-3-methyl-benz(j)aceanthrylen 3-MCA RCRA waste number U157 3-Methoxycholanthrene 3-methyl-i,j-cyclopentabenz(a)anthracene 3-methyl-cholanthren Benz(j)aceanthrylene, 1,2-dihydro-3-methyl- 3-Methylcholanthrene (20) 3-Methylcholanthren (20-) 3-甲基胆蒽溶液 3-methylcholanthrene 3-methylcyclopentabenzophenanthrene 20-MC Benz[j]aceanthrylene, 1,2-dihydro-3-methyl- 2O-Methylcholanthren 3-Methylcholanthrene benz[j]aceanthrylene, 1,2-dihydro-3-methyl- 甲基膽蒽 1,2-dihydro-3-methylbenz[j]aceanthrylene
MDL NumberMFCD00003704
PubChem Substance ID57647926
EC Number200-276-4
Beilstein Registry Number1913890
Chemical Name Translation3-甲基胆蒽
Merck Number13,6072
Wiswesser Line NotationL E6 D6656 1A T&&&T&J R1
LabNetwork Molecule IDLN01301455
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; alicycle; large ring; fused rings; 5ring; 6ring; 9ring; 10ring; 11ring; 13ring; 14ring; 15ring; 17ring; 18ring; 19ring; 1fragment
  • {SNA} Carcinogens, Cell Biology, 癌症研究
  • Mutagenesis Research Chemicals
  • {SNA} Alphabetical Index of Analytical Standards, All PAH Standards, Alpha Sort, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, M, META - METH, PAHs,
  • {
  • {SNA} Alpha Sort, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chromatography, Environmental Standards, M, META - METH, Volatiles/ Semivolatiles
  • {SNA} Carcinogens, 癌症研究, 细胞生物学

产品应用

  • 致癌物质，常用来诱导培养细胞的转化；在实验动物身上诱导纤维肉瘤和皮肤癌。

相关文献及参考

  • Merck:13,6072 Beilstein: 5,IV,2648
  • Short: II/27B
  • Merck:13,6072
  • Short: II/3

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H332 Harmful if inhaled 吸入有害
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H312 Harmful in contact with skin 皮肤接触有害
  • H302 Harmful if swallowed 吞食有害
  • H350 May cause cancer 可能致癌
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Signal word Danger
RTECSFZ3675000
Hazard Codes T F,Xn T,Xn,F
Risk Statements
  • R45 May cause cancer 可能致癌
  • R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
  • R36 Irritating to eyes 刺激眼睛
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R11 Highly flammable 非常易燃
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
Storage condition 储存温度2-8°C 2-8°C
Packing GroupIII
Hazard Class6.1(b)
UN Number 2811 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher infor

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg/15D-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,1155,1962

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   29,1927,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JCROD7 Journal of Cancer

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intrapleural
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer.  (Paris,
   France)  V.1-52, 1908-65. For publisher information, see BUCABS.
   Volume(issue)/page/year: 27,706,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intrarenal
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   24,1969,1964

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   64,637,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 750 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

{h

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 1 ug/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere P

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Fish - not otherwise specified Cells - not otherwise
                          specified
DOSE/DURATION           : 1 mg/L/48H
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,181,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 74,107,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 20 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 74,113,1980

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 189 mg/kg
SEX/DURATION            : female 15-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   72,417,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 64 mg/kg
SEX/DURATION            : female 9-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,567,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 19-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   73,457,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproduc

其他信息

  • Sigma Aldrich:56-49-5(sigmaaldrich)
  • 用途一:致癌物质，常用来诱导培养细胞的转化；在实验动物身上诱导纤维肉瘤和皮肤癌。
  • 3-甲基胆蒽价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 S21394201 3-甲基胆蒽 98％ 100mg 2689元
  • MOL 文件:56-49-5.mol

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Carcinogens - Cancer Research
  1. Life Science 生命科学
  2. Cancer Research
  3. Carcinogens - Cancer Research
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. PAHs - Volatiles/ Semivolatiles
  7. All PAH Standards - PAHs
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. M - Alphabetic
  5. META - METH - M

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