细胞松驰素 E 细胞松驰素 E

CAS 36011-19-5 MFCD00005178

化学结构图

36011-19-5
SMILES: C[C@]12O[C@H]1[C@@H]1C=CC[C@H](C)C(=O)[C@](C)(O)C=COC(=O)O[C@]31[C@H]([C@H](CC1C=CC=CC=1)NC3=O)[C@@H]2C |c:28,30,t:6,16,32|

化学属性

Mol. FormulaC28H33NO7
Mol. Weight496
Melting Point225

别名和识别编码

Chemical NameCytochalasin E from Aspergillus clavatus
MDL NumberMFCD00005178
PubChem Substance ID24892467
Beilstein Registry Number1096975
EC Number252-835-7
Synonym Cytochalasin E from Aspergillus clavatus 松胞菌素 E 来源于棒曲霉
Chemical Name Translation细胞松驰素 E
CAS Number36011-19-5
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分类

  • {SNA} Actin Inhibitors and Probes, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Mold, Toxins and Venoms
  • {SNA} Actin Inhibitors and Probes, Bioactive Small Molecule Alphabetical Index, CI-CZ, Cytoskeleton and Extracellular Matrix, Mold, Toxins and Venoms, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P310
  • P302+P350
Hazard statements
  • H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
  • H330 Fatal if inhaled 吸入致命
  • H310 Fatal in contact with skin 皮肤接触致命
  • H300 Fatal if swallowed 吞食致命
RTECSHA5360000
Signal word Danger
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes 6.1 T+
Safety Statements
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有剧毒
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
UN Number 1544
Packing GroupII
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 9100 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,135,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 500 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,135,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2600 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,135,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1300 ug/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Behavioral - coma
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   32,135,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3900 ug/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 25,11,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3600 ug/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 25,11,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 8100 ug/kg
SEX/DURATION            : female 7-9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 38,438,1979

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