2-Benzylimidazoline 2-苯甲基咪唑啉

CAS 59-98-3 MFCD00005182

化学结构图

59-98-3
SMILES: c1ccc(CC2=NCCN2)cc1

化学属性

Mol. FormulaC10H12N2
Mol. Weight160
Melting Point64.0 to 68.0 deg-C
Boiling Point188°C/20mmHg(lit.)

别名和识别编码

Chemical Name2-Benzylimidazoline
Synonym 2-苄基咪唑啉 2-BENZYL-2-IMIDAZOLINE 2-苄基-4,5-二氢-1H-咪唑 Peripherine Tolazoline Benzazoline 2-苄-4,5-咪唑啉 Imidalin 2-Benzyl-2-imidazoline Artonil 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole 2-Benzylimidazoline; 2-Benzyl-4,5-dihydro-1H-imidazole; 4,5-Dihydro-2-(phenylmethyl)-1H-imidazole 2-Benzyl-4,5-dihydro-1H-imidazole Kasimid 4,5-dihydro-2-(phenylmethyl)-1h-imidazol ciba3259 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- TIMTEC-BB SBB003964 Ciba 3259 托拉佐林 TOLAZOLINE Benzylimidazoline LABOTEST-BB LT00772362 Lambril Priscol 2-Benzylimidazoline 2-Imidazoline, 2-benzyl- Priscoline Vasodil Phenylmethylimidazoline 2-benzyl-2-imidazolin 2-Benzyl-4,5-imidazoline Benzidazol 2-Benzyl-4,5-imidazoline hydrochloride Vasimid 妥拉苏林 Benzolin Divascol 2-苯甲基咪唑啉 Prefaxil 2-苄基-2-咪唑啉 2-苄基-4,5-二氢-1H-咪唑 Benzidazol NSC 35110 Phenylmethylimidazoline 托拉佐林 CIBA 3259 妥拉唑林 Olitensol Dilatol ASI Vasodilatan
CAS Number59-98-3
MDL NumberMFCD00005182
PubChem Substance ID135726884
EC Number200-448-9
Reaxys-RN128757
Merck Number9506
Chemical Name Translation2-苯甲基咪唑啉
Wiswesser Line NotationT5M CN BUTJ B1R
Beilstein Registry Number0128757
LabNetwork Molecule IDLN00246265
InChIInChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
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分类

  • {SNA} B, Bioactive Small Molecules, Building Blocks, Cell Biology, Chemical Synthesis, Heterocyclic Building Blocks, Imidazolines/Imidazolidines
  • {SNA} B, Bioactive Small Molecules, Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Imidazolines/Imidazolidines, 细胞生物学
  • {SNA} Building Blocks, Chemical Synthesis, Heterocyclic Building Blocks, Imidazolines/Imidazolidines

相关文献及参考

  • [1]. Tolazoline, From Wikipedia

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P304+P340+P312
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P332+P313
  • P302+P352+P312+P362+P364
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P305+P351+P338+P337+P313
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P302+P350
  • P337+P313
Hazard statements
  • H302+H312+H332
  • H332 Harmful if inhaled 吸入有害
  • H315 Causes skin irritation 会刺激皮肤
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSNJ1925000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Safety Statements
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition 0-10 0-10°C
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBPHAW Progress in Biochemical Pharmacology.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1965-  Volume(issue)/page/year:
   1,542,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 350 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 22,514,1974

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - species unspecified
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 192,141,1939

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 37,198,1974

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 62500 ug/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

其他信息

  • 储运特性:库房通风低温干燥; 与食品原料分开储运
  • 急性毒性:口服-小鼠 LD50: 350 毫克/公斤; 腹腔-小鼠 LD50: 160 毫克/公斤
  • 毒性分级:高毒
  • 可燃性危险特性:可燃; 受热放出有毒氧化氮气体
  • MOL 文件:59-98-3.mol
  • 灭火剂:水、二氧化碳、砂土、泡沫
  • Sigma Aldrich:59-98-3(sigmaaldrich)
  • 类别:有毒物品

系列性分类


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