Tetramisole hydrochloride 四咪唑 盐酸盐

CAS 5086-74-8 MFCD00005536

化学结构图

5086-74-8
SMILES: Cl.c1ccc(C2CN3CCSC3=N2)cc1

化学属性

Mol. FormulaC11H12N2S·HCl
Mol. Weight241
Melting Point266-267
Solubility200 g/L (20 °C)

别名和识别编码

Chemical NameTetramisole hydrochloride
MDL NumberMFCD00005536
CAS Number5086-74-8
Synonym ()-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride (+/-)-2,3,5,6-TETRAHYDRO-6-PHENYLIMIDAZO[2,1-B]THIAZOLE HYDROCHLORIDE (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]t (±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride Bayer 9051 DL-2,3,5,6-TETRAHYDRO-6-PHENYL-IMIDAZO-[2,1-B]-THIAZOLE HYDROCHLORIDE DL-6-Phenyl-2,3,5,6-tetrahydroimidazole(2,1-b)thiazole-hydrochloride DL-Tetramisole hydrochloride McN-JR-8299 Nilverm Orovermol R 8299 Ripercol Ripereol Spartakon TETRAMISOLE HYDROCHLORIDE Tetramisol hydrochloride Tetramisole citarin dl-6-phenyl-2,3,5,6-tetrahydroimidazole(2,1-b)thiazole-hydrochloride dl-tetramisolehydrochloride nilverm nilverom {}
PubChem Substance ID68628
Beilstein Registry Number4358989
EC Number225-799-5
Chemical Name Translation四咪唑 盐酸盐
Merck Number13,5480
Wiswesser Line NotationT55 AN DN FS DUTJ CR &GH -R
LabNetwork Molecule IDLN01312923
InChIInChI=1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H
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分类

  • {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, P to Q, Phosphatase, Alkaline - Inhibitors, 酶、抑制剂和底物
  • {SNA} Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards, Imidazothiazoles
  • {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, P to Q, Phosphatase, Alkaline - Inhibitors, 生化试剂, 酶、抑制剂和底物
  • {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Chemical Structure, Chromatography, Clinical Standards, Imidazothiaz

相关文献及参考

  • [1]. Nowak LG, et al. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex. Subcell Biochem. 2015;76:239-81.

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
RTECSNJ5950000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn Xn,Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 210 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subsc

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 24 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 209,1084,1966

TYPE OF TEST

其他信息

  • Sigma Aldrich:5086-74-8(sigmaaldrich)
  • 盐酸四咪唑价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 187860100 盐酸四咪唑 Tetramisole hydrochloride 99+% 10 GR 631元
  • Acros Organics:四咪唑盐酸 Tetramisole hydrochloride, 99+%(5086-74-8)
  • MOL 文件:5086-74-8.mol
  • 图谱信息:盐酸四咪唑(5086-74-8)核磁图( 13 CNMR) 盐酸四咪唑(5086-74-8)红外图谱(IR2) 盐酸四咪唑(5086-74-8)红外图谱(IR1) 盐酸四咪唑(5086-74-8)质谱(MS) 盐酸四咪唑(5086-74-8)核磁图( 1 HNMR)
  • 用途一:用作左旋咪唑中间体、抗蠕虫药
  • MSDS 信息:DL-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride(5086-74-8).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. P to Q - Enzyme Inhibitors by Enzyme
  7. Phosphatase, Alkaline - Inhibitors - P to Q
  1. Chemical Synthesis 化学合成
  2. Asymmetric Synthesis 不对称合成
  3. Chiral Building Blocks 手性分子砌块
  4. Heterocyclic Building Blocks - Chiral Building Blocks
  5. Others - Heterocyclic Building Blocks
  1. Functional Group 官能团索引
  2. isothiourea
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Aldehyde dehydrogenase
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Enzyme Inhibitors
  5. Enzyme Inhibitors by Enzyme
  6. Phenylalanine ammonia-lyase
  1. Medical Research Areas
  2. Metabolism
  3. Phosphatase  (磷酸酶)

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