Nocodazole 诺考达唑

CAS 31430-18-9 MFCD00005588

化学结构图

31430-18-9
SMILES: COC(=O)NC1NC2C=CC(=CC=2N=1)C(=O)C1=CC=CS1

化学属性

Mol. FormulaC14H11N3O3S
Mol. Weight301
Melting Point300 °C (dec.)

别名和识别编码

Chemical NameNocodazole
CAS Number31430-18-9
Synonym Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate Methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate Oncodazole R 17934 [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester Oncodazole Methyl N-(5-thenoyl-2-benzimidazolyl)carbamate [5-(2-Thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamic acid methyl ester
MDL NumberMFCD00005588
PubChem Substance ID24278535
Beilstein Registry Number1085978
EC Number250-626-5
Chemical Name Translation诺考达唑
Wiswesser Line NotationT56 BM DNJ CMVO1 GV- BT5SJ
FormulaC14H11N3O3S
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分类

  • Heterocycles
  • Pharmaceuticals
  • {SNA} Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, N
  • {SNA} Bioactive Small Molecule Alphabetical Index, Cytoskeleton and Extracellular Matrix, Microtubule Inhibitors, N,

产品应用

  • Nocodazole is an anti-neoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules. Microtubules are one type of fibre which constitutes the cytoskeleton, and the dynamic microtubule network has several important roles in the cell, including vesicular transport, forming the mitotic spindle and in cytokinesis. Several drugs including vincristine and colcemid are similar to nocodazole in that they interfere with microtubule polymerisation. (Source: http://en.wikipedia.org/wiki/Nocodazole)

相关文献及参考

  • [2]. Keliang Xu, et al. Interaction of nocodazole with tubulin isotypes. Drug Development Research 2002
  • [3]. Wang YJ, et al. R-41400 potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Mol Carcinog. 2002 Aug;34(4):199-210.
  • [4]. Signoretto E, et al. Nocodazole Induced Suicidal Death of Human Erythrocytes. Cell Physiol Biochem. 2016;38(1):379-92.
  • [5]. Zhang JP, et al. Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage. Genome Biol. 2017 Feb 20;18(1):35.
  • ########
  • [1]. Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6.
  • [1]. Park H, et al. Nocodazole is a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK. ChemMedChem. 2012 Jan 2;7(1):53-6.
  • [2]. Keliang Xu, et al. Interaction of nocodazole wi

安全信息

RTECSDD6521000
GHS Symbol
Precautionary statements
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard statements
  • H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
WGK Germany3
Signal word Warning
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Hazard Codes Xn
Risk Statements
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
  • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
Safety Statements
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 39530 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCISP* National Cancer Institute Screening Program Data Summary,
   Developmental Therapeutics Program. (Bethesda, MD 20205)
   Volume(issue)/page/year: JAN1986

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 35 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 210,313,1989

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 190,137,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 4,6,1989

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mammal - species unspecified
DOSE/DURATION           : 2 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 201,423,1988

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, U

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - mouse Cells - not otherwise specified
DOSE/DURATION           : 1 mg/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 10 mg/kg
SEX/DURATION            : female 1 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 210,313,1989

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. N - Bioactive Small Molecules
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Microtobule Inhibitors - Cytoskeleton and Extracellular Matrix
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Acridines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Benzimidazoles 苯并咪唑
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Imidazoles 咪唑
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. C - Alphabetic
  5. CH - C
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Cytoskeleton and Extracellular Matrix
  5. Extracellular Matrix
  6. Angiogenesis Regulators
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Cytoskeleton and Extracellular Matrix Proteins
  6. Extracellular Matrix
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Apoptosis and Cell Cycle Proteins
  7. Apoptosis Inhibitors
  1. Medical Research Areas
  2. Cell Cycle
  3. Rho
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. Microtubule/Tubulin  (微管/微管蛋白)

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