5-Hydroxy-DL-Tryptophan 5-羟基-DL-色氨酸

CAS 56-69-9 MFCD00005651

化学结构图

56-69-9
SMILES:

化学属性

Mol. FormulaC₁₁H₁₂N₂O₃
Mol. Weight220.22
Melting Pointca 298° dec.
TSCAYes
Density1.484
SolubilitySoluble in water (4 mg/ml at 25 °C), DMSO (44 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and methanol.

别名和识别编码

Chemical Name5-Hydroxy-DL-Tryptophan
Synonym 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)-PROPIONIC ACID 2-AMINO-3-(5-HYDROXY-1H-INDOL-3-YL)PROPANOIC ACID 5-HYDROXY-DL-TRYPTOPHAN 5-HYDROXYTRYPTOPHAN 5-Htp 5-Hydroxy Tryptophan {Chemicalbook} DL-2-氨基-3-(5-羟基吲哚)丙酸 DL-5-HTP DL-5-HTP DL-2-Amino-3-(5-hy {} {ALF} DL-2-Amino-3-[3-(5-hydroxyindole)]propionic acid {} {} {Chemicalbook} DL-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID {} {} {} {Chemicalbook} 5-羟基色氨酸 {} {} {} {} {Chemicalbook} 5-羟基胰化蛋白氨基酸 {} {} {} {} {} {Chemicalbook} 5-羟基-DL-色氨酸 {} {} {} {} {} {} {Chemicalbook} 5-hydroxytrytophan {} {} {} {} {} {} {} {Chemicalbook} 5-hydroxytryptophane {} {} {} {} {} {} {} {} {Chemicalbook} 5-hydroxy-tryptopha {} {} {} {} {} {} {} {} {} {hazard_com} 5-Hydroxytrytophan {} {} {} {} {} {} {} {} {} {} {hazard_com} 5-Hydroxytryptophane {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {Chemica
MDL NumberMFCD00005651
CAS Number56-69-9
Beilstein Registry Number88199
EC Number200-284-8
Merck Number4847
Chemical Name Translation5-羟基-DL-色氨酸
Reaxys-RN88199
PubChem Substance ID87570731
Wiswesser Line NotationT56 BMJ D1YZVQ GQ
LabNetwork Molecule IDLN00192906
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产品应用

  • A tryptophan metabolite

相关文献及参考

  • [2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9.
  • [3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder patients. Psychiatry Res. 2002 Dec 30;113(3):237-43.
  • [1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9.
  • [1]. Gartside SE, et al. Mediation of ACTH and prolactin responses to 5-HTP by 5-HT2 receptors. Eur J Pharmacol. 1990 Apr 10;179(1-2):103-9.
  • [2]. Gijsman HJ, et al. Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers. J Clin Psychopharmacol. 2002 Apr;22(2):183-9.
  • [3]. Schruers K, et al. Acute L-5-hydroxytryptophan administration inhibits carbon dioxide-induced panic in panic disorder

安全信息

RTECSYN7000000
WGK Germany3
Packing GroupIII
Storage condition 0-10°C 2-8°C 4
UN Number 2811
Safety Statements
  • S22 Do not breathe dust 不要吸入粉尘;
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277-689

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - mating performance (e.g. # sperm positive females
   per # females mated; # copulations per # estrus cycles)
REFERENCE :
   ANENAG Annales d'Endocrinologie.  (Masson Editeur, 120 Blvd. Saint-Germain,
   F-25280 Paris Cedex 06, France)  V.1-    1939-  Volume(issue)/page/year:
   24(Suppl 3),1,1963

其他信息

  • 5-Hydroxy Tryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor that is used to assess central serotonergic function.
  • 5-羟基色氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62015480 5-羟基-DL-色氨酸(+4°C) 1g 110元 2010/05/25 A12237 DL-5-羟基色氨酸, 99% DL-5-Hydroxytryptophan, 99% 5g 2380元 2010/05/25 A12237 DL-5-羟基色氨酸, 99% DL-5-Hydroxytryptophan, 99% 1g 524元
  • MOL 文件:56-69-9.mol
  • 用途一:生化研究。5-羟色氨酸是人体血清素的前体物质,可以帮助人体平衡这种荷尔蒙从而控制人体情绪、提高睡眠质量,并可以有效控制食欲,提高饱食中枢的敏感性,在减肥过程的饮食控制中,降低饥饿感,使减肥过程更轻松容易达成。
  • Sigma Aldrich:56-69-9(sigmaaldrich)
  • Alfa Aesar:DL-5-羟基色氨酸,99% DL-5-Hydroxytryptophan, 99%(56-69-9)
  • MSDS 信息:DL-2-Amino-3-(5-hydroxyindolyl)propionic acid(56-69-9).msds
  • 外观性质:白色结晶。固体时稳定,酸性溶液在-10℃时可稳定一年以上。中性或碱性溶液可增加其对氧的作用,惰性气体可防止其分解。溶解度(g/100ml):水中5℃时为1,100℃时为5.5;50%沸乙醇中为2.5。熔点:291~294℃。在298~300℃时分解密度:1.484

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