2-(Chloromethyl)Isoindoline-1,3-Dione 2-(氯甲基)异吲哚啉-1,3-二酮
CAS 17564-64-6 MFCD00005898
化学结构图
SMILES: O=C1C2C=CC=CC=2C(=O)N1CCl
化学属性
| Mol. Formula | C9H6ClNO2 |
|---|---|
| Mol. Weight | 196 |
| Melting Point | 131-135 |
| TSCA | Yes |
| Solubility | 略溶于水 |
别名和识别编码
| Chemical Name | 2-(Chloromethyl)Isoindoline-1,3-Dione |
|---|---|
| Synonym | N-chloromethyl-phthalimide {uni_hamburg} N-(chloromethyl)phthalimide N-Chlormethylphthalimid N-chloromethyl phthalimide 1H-Isoindole-1,3(2H)-dione, 2-(chloromethyl)- Phthalimide, N-(chloromethyl)- N-Chloromethyltrimellitimide Chlormethylphthalimid N-氯甲基邻苯二甲酰亚胺 Phthalimide, N-chloromethyl- N-Chlormethyl-phthalimid Chloromethylphthalimide |
| MDL Number | MFCD00005898 |
| PubChem Substance ID | 87563154 |
| Beilstein Registry Number | 140942 |
| EC Number | 241-541-4 |
| CAS Number | 17564-64-6 |
| Alfabeta Name | CHLOROMETHYLISOINDOLEDIONE HH21132(())-----, |
| Reaxys-RN | 140942 |
| Chemical Name Translation | 2-(氯甲基)异吲哚啉-1,3-二酮 |
| LabNetwork Molecule ID | LN00184839 |
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分类
- {SNA} Building Blocks, Carbonyl Compounds, Chemical Synthesis, Cyclic Imides, Organic Building Blocks
- {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 5ring; 6ring; 9ring; amide; lactame; 1fragment
相关文献及参考
- Also reported for the protection of thiols as the S-phthalimidomethyl (Pim) derivative. Cleavage is by hydrazinolysis, followed by Hg(II), Cu(II) or I2: Chem. Lett., 2139 (1994).
- Reagent for carboxyl protection, e.g. in peptide synthesis, by reaction in the presence of an amine: Rec. Trav. Chim., 82, 941 (1963); or with KF in DMF: Synth. Commun., 8, 515 (1978). The phthalimidomethyl ester can be cleaved in various ways including hydrazinolysis, HBr in acetic acid or Zn/AcOH. See also N-(Hydroxymethyl)phthalimide, B21292 and Appendix 6.
- Also reported for the protection of thiols as the S-phthalimidomethyl (Pim)
- Reagent for the amidomethylation of aromatic systems. For reviews of amidomethylation, see: Org. React., 14, 52 (1965); Synthesis, 49 (1970); 85, 181 (1984).
- Short: EINECS
- Short: III/31a
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P310
- P305+P351+P338
- P305+P351+P338+P337+P313
- P332+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H319 Causes serious eye irritation 严重刺激眼睛
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- S37 Wear suitable gloves 戴适当手套；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
- R52/53
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