5-Amino-4,6-dichloropyrimidine 4,6-二氯-5-氨基嘧啶

CAS 5413-85-4 MFCD00006108

化学结构图

5413-85-4
SMILES: Nc1c(Cl)ncnc1Cl

化学属性

Mol. FormulaC4H3Cl2N3
Mol. Weight163.99
Melting Point145-148°C
TSCAYes
Density1.606
Solubility略溶于水
Stability对湿度敏感
Boiling Point267.1°C at 760 mmHg

别名和识别编码

Chemical Name5-Amino-4,6-dichloropyrimidine
CAS Number5413-85-4
Alfabeta NameAMINODICHLOROPYRIMIDINE 546---,
MDL NumberMFCD00006108
Synonym 4,6-Dichloropyrimidin-5-amine {LY} 4,6-Dichloropyrimidin-5-amine {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4,6-Dichloropyrimidin-5-amine {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID79434
Beilstein Registry Number126885
EC Number226-503-7
Reaxys-RN126885
Chemical Name Translation4,6-二氯-5-氨基嘧啶
InChIKeyNIGDWBHWHVHOAD-UHFFFAOYSA-N
LabNetwork Molecule IDLN00007841
InChIInChI=1S/C4H3Cl2N3/c5-3-2(7)4(6)9-1-8-3/h1H,7H2
Canonical SMILESClC1=C(N)C(Cl)=NC=N1
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分类

  • Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines
  • {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Pyrimidines

产品应用

  • 用于在微波加热至 150°C 时，采用三步工艺制造嘧啶并-氧氮杂卓。

相关文献及参考

  • Beilstein:25(3/4)2139
  • Griffith, D., et al.: J. Med. Chem., 52, 234 (2009),
  • Lebsack, A., et al.: Bioorg. Med. Chem. Lett., 19, 40 (2009),
  • Lambertucci, C., et al.: Bioorg. Med. Chem., 17, 2812 (2009),

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition -20°C, sealed storage, away from moisture and light {LY} -20°C, sealed storage, away from moisture and light 2-8°C, protect from light Moisture Sensitive {} {LY} -20°C, sealed storage, away from moisture and light {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture and light {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, sealed storage, away from moisture

其他信息

  • MSDS 信息:5-Amino-4,6-dichloropyrimidine(5413-85-4).msds
  • Acros Organics:4.6-二氯-5-氨基嘧啶 5-Amino-4,6-dichloropyrimidine, 97%(5413-85-4)
  • TCI Shanghai:5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine,>;98.0%(N)(5413-85-4)
  • 上游原料:乙酸乙酯 --> 硝酸 --> 三氯氧磷 --> 正己烷 --> 三氟乙酸 --> 氯化亚锡 --> N,N-二异丙基乙胺 --> 4,6-二羟基嘧啶
  • 用途一:用于医药中间体的合成
  • F:10-21
  • 微溶于水。
  • 4,6-二氯-5-氨基嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 A1395 5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine 1G 637元 2014/06/02 A1395 5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine 25G 6530元 2014/06/02 A1395 5-氨基-4,6-二氯嘧啶 5-Amino-4,6-dichloropyrimidine 5G 1870元
  • MOL 文件:5413-85-4.mol
  • 下游产品:4,5-二氨基嘧啶
  • 敏感性:Moisture Sensitive
  • Sigma Aldrich:5413-85-4(sigmaaldrich)
  • Alfa Aesar:5-氨基-4,6-二氯嘧啶,98+% 5-Amino-4,6-dichloropyrimidine, 98+%(5413-85-4)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrimidines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyrimidines - Halogenated Heterocycles
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyrimidines 嘧啶
  5. C4 to C5 - Pyrimidines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Halogenated Heterocycles 卤代杂环
  5. Pyridines
  1. C9 to C46

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