Thymidine 胸苷

CAS 50-89-5 MFCD00006537

化学结构图

50-89-5
SMILES: Cc1cn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)[nH]c1=O

化学属性

Mol. FormulaC10H14N2O5
Mol. Weight242.23
Melting Point186-188°C
TSCAYes
Density1.452
Stability对光敏感
SolubilitySOLUBLE
Refractive index33 ° (C=1, 1mol/L NaOH)
Boiling Point385.05 °C at 760 mmHg

别名和识别编码

Chemical NameThymidine
CAS Number50-89-5
Alfabeta NameHYDROXYHYDROXYMETHYLTETRAHYDROFURANYLMETHYLPYRIMIDINEDIONE RSRHH124545252413(((())))------------,,,,
MDL NumberMFCD00006537
Synonym Thymidine {LY} Thymidine {} {LY} Thymidine {} {} {LY} Thymidine {} {} {} {LY} Thymidine {} {} {} {} {LY} Thymidine {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Thymidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY
PubChem Substance ID5789
Beilstein Registry Number89285
EC Number200-070-4
Merck Number9397
Chemical Name Translation胸苷
Reaxys-RN89285
Wiswesser Line NotationT6NVMVJ E1 A- ET5OTJ B1Q CQ
LabNetwork Molecule IDLN00173067
InChIInChI=1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
Canonical SMILESO[C@H]1C[C@H](N2C(NC(C(C)=C2)=O)=O)O[C@@H]1CO
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分类

  • {SNA} Biochemicals and Reagents, Nucleosides, Nucleosides, Nucleotides, Oligonucleotides
  • {SNA} Core B
  • {SNA} Core Bioreagents,
  • {SNA} Bioactive Small Molecules, Cell Biology, Cell Culture, Conditioned Media, Media Supplements and Reagents, Hybridoma Reagents, Miscellaneous Reagents and Supplements, Reagents and Supplements,
  • {SNA} Conditioned Media, Media Supplements and Reagents, Hybridoma Reagents,
  • {SNA} Core Bioreagen

产品应用

  • 主要用于抗艾滋病药物(如齐多呋啶、石达呋啶)的制备

相关文献及参考

  • [2]. FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4604):274-5.
  • [3]. Izeradjene K, et al. Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independentdeletion of superantigen-reactive peripheral T cells. Int Immunol. 2001 Jan;13(1):85-93.
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
  • Short: III/10a Title: Structure Data of Organic Crystals: C ... C 15 Author: Schudt-Weitz, G.; Strell, I. E

安全信息

Warnings IRRITANT
WGK Germany3
RTECSXP2071000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
GHS Symbol
Signal word Danger
Precautionary statements
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P305+P351+P338
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2512 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 207,504,1978

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 46,305,1977

{hazard_c

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 500 umol/L
REFERENCE :
   CYTOAN Cytologia.  (Japan Pub. Trading Co. (USA), 1255 Howard St., San
   Francisco, CA 94103) V.1-    1929-  Volume(issue)/page/year: 49,667,1984

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 200,249,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 200 umol/L
REFERENCE :
   BICMBE Biochimie.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.53-    1971-
   Volume(issue)/page/year: 64,809,1982

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 gm/L
REFERENCE :
   ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie.  (Akademi

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,2872,1975

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Fibroblast

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 400 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 32,32A,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 800 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 32,229,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 20 gm/kg
SEX/DURATION            : male 5 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 200,249,1988

Hazard statements
  • H302 Harmful if swallowed 吞食有害

其他信息

  • 易溶于水、甲醇、热乙醇、热丙醇、热丙酮、热乙酸乙酯、吡啶、冰醋酸中,少量溶于热的氯仿中。水中溶解度:46 g/L (20°C)。
  • 下游产品:齐多夫定 --> 司他夫定
  • beta-胸苷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 65011580 胸腺核苷 1g 169.4元 2011/04/16 T0233 胸苷 Thymidine 1G 273元 2011/04/16 T0233 胸苷 Thymidine 25G 2100元
  • 外观性质:白色或浅色针状结晶.易溶于水、甲醇、热乙醇、热丙醇、热丙酮、热乙酸乙酯、吡啶、冰醋酸中,少量溶于热的氯仿中。水中溶解度:46 g/L (20°C)。熔点:187-189 °C [a]20/D: 18.5° (c=3, H2O)
  • Sigma Aldrich:50-89-5(sigmaaldrich)
  • MOL 文件:50-89-5.mol
  • 图谱信息:beta-胸苷(50-89-5)核磁图( 13 CNMR) beta-胸苷(50-89-5)质谱(MS) beta-胸苷(50-89-5)Raman光谱 beta-胸苷(50-89-5)核磁图( 1 HNMR) beta-胸苷(50-89-5)红外图谱(IR2) beta-胸苷(50-89-5)红外图谱(IR1)
  • 用途一:主要用于抗艾滋病药物(如齐多呋啶、石达呋啶)的制备。
  • MSDS 信息:Thymine deoxyriboside(50-89-5).msds
  • F:10
  • 用途二:用作医药中间体,用于合成抗病毒和抗HIV药
  • Alfa Aesar:胸苷,99% Thymidine, 99%(50-89-5)
  • Acros Organics:胸苷/胸腺嘧啶核苷 Thymidine, 99+%(50-89-5)
  • TCI Shanghai:胸腺嘧啶脱氧核苷 Thymidine,>;98.0%(LC)(T)(50-89-5)
  • 比旋光度:18.6 ° (c=3, H2O)
  • 用途三:主要用于抗艾滋病药物(如齐多呋啶、石达呋啶)的制备

系列性分类


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