4-Nitroquinoline N-Oxide 4-硝基喹啉-N-氧化物

CAS 56-57-5 MFCD00006738

化学结构图

56-57-5
SMILES:

化学属性

Mol. FormulaC9H6N2O3
Mol. Weight190
Melting Point155
TSCANo
Density1.42
Solubilityacetone: clear to hazy

别名和识别编码

Chemical Name4-Nitroquinoline N-Oxide
Synonym 4-nitrochinolinn-oxid NITROQUINOLINE-N-OXIDE 4-NITROQUINOLINE N-OXIDE 98+% 4-NQO N-NITROQUINOLINE-N-OXIDE, 1000MG, NEAT 4-NITROQUINOLINE N-OXIDE 4-nqo 4-NITROQUINOLINE N-OXIDE POWDER TIMTEC-BB SBB006266 4-硝基氮氧化喹啉, 98+% Quinoline, 4-nitro-, 1-oxide nitrochin NITROQUINOLINE-1-OXIDE 4-NITRO-1-QUINOLINIUMOLATE Nitrochin; 4-Nitroquinoline 1-oxide; 4-Nitroquinoline oxide 4-硝基喹啉-N-氧化物 4-Nitroquinoline-1-oxide 4-NITROQUINOLINE 1-OXIDE 4-nitrochinolinn-oxid(swedish) 4-NITROCHINOLINE-N-OXIDE 4-NITROQUINOLINIUM-1-OLATE 4-nitro-quinolin1-oxide 4-Nitroquinoline-N-oxide 1-氧化-4-硝基喹啉 4-NQO 1-氧化-4-硝基喹啉 4-Nitroquinoline-N-oxide, HPLC 98% Nitrochin 4-Nitrochinolin N-oxid Nitroquinolineoxide 4-nitroquinolineoxide
MDL NumberMFCD00006738
PubChem Substance ID87573611
Beilstein Registry Number165756
CAS Number56-57-5
EC Number200-281-1
Reaxys-RN165756
Chemical Name Translation4-硝基喹啉-N-氧化物
Wiswesser Line NotationT66 BNJ BO ENW
LabNetwork Molecule IDLN00221860
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分类

  • Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Heterocyclic Building Blocks, Quinolines

产品应用

  • 用于有机合成。

相关文献及参考

  • Beilstein: 20,V,7,324
  • Powerful mutagen, forming charge-transfer complexes with deoxynucleotides: Biochemistry, 17, 1352 (1978); 18, 3833 (1979).

安全信息

Hazard statements
  • H302+H312+H332
  • H350 May cause cancer 可能致癌
RTECSVC2100000
GHS Symbol
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P308+P313
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P305+P351+P338
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P302+P350
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P304+P340
  • P301+P312
  • P302+P352
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
Hazard Codes T
WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
Signal word Danger
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
Storage condition -20°C 储存温度：-20°C
Packing GroupII
Hazard Class6.1
UN Number 2811 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1600 ug/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   APJAAG Acta Pathologica Japonica.  (Japan Publications Trading Co., Ltd.,
   POB 5030, Tokyo International, Tokyo 101-31, Japan)  V.1-    1951-
   Volume(issue)/page/year: 23,87,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 84 mg/kg/14W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   48,129,1957

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Skin and Appendages - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg/12W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   58,389,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,911,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12600 ug/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Lungs, Thorax, or Respiration - dyspnea
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JJPAAZ Japanese Journal of Pharmacology.  (Japanese Pharmacological Soc.,
   c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto
   606, Japan)  V.1-    1951-  Volume(issue)/page/year: 20,264,1970

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   13,285,1964

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 30 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 9,134,1970

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 200 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   5,351,1972

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Multiple routes
TEST SYSTEM             : Fish - not otherwise specified
DOSE/DURATION           : 20 umol/L
REFERENCE :
   PPTCBY Proceedings of the International Symposium of the Princess Takamatsu
   Cancer Research Fund. (Japan Scientific Soc. Press, 6-2-10 Hongo, Bunkyo-ku,
   Tokyo 113, Japan)  1st-    1971-  Volume(issue)/page/year: 10,215,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ng/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences,

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 400 pmol/L
REFERENCE :
   IUSMDJ ICN-UCLA Symposia on Molecular and Cellular Biology.  (Menlo Park,
   CA)  V.1-23, 1974-81.  Volume(issue)/page/year: 7,341,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Mammal - cattle Cells - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   PPTCBY Proceedin

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   49VWAG "Female Transcervical Sterilization, Proceedings of an International
   Workshop on Non-Surgical Methods for Female Tubal Occlusion, Chicago, 1982,"
   Zatuchni, G.I., et al., eds., New York, Harper & Row, 1983
   Volume(issue)/page/year: -,71,1983

其他信息

  • Sigma Aldrich:56-57-5(sigmaaldrich)
  • Acros Organics:4-硝基喹啉-N-氧化物 4-Nitroquinoline-N-oxide, 98%(56-57-5)
  • Alfa Aesar:4-硝基氮氧化喹啉,98+% 4-Nitroquinoline N-oxide, 98+%(56-57-5)
  • 4-硝基喹啉-N-氧化物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0250 4-硝基喹啉N-氧化物 4-Nitroquinoline N-Oxide 1G 686元 2014/06/02 N0250 4-硝基喹啉N-氧化物 4-Nitroquinoline N-Oxide 5G 2470元 2010/06/21 203792500 4-硝基喹啉-N-氧化物 4-Nitroquinoline-N-oxide 98% 250 MG 542元
  • 图谱信息:4-硝基喹啉-N-氧化物(56-57-5)红外图谱(IR3) 4-硝基喹啉-N-氧化物(56-57-5)红外图谱(IR1) 4-硝基喹啉-N-氧化物(56-57-5)核磁图( 13 CNMR) 4-硝基喹啉-N-氧化物(56-57-5)红外图谱(IR2) 4-硝基喹啉-N-氧化物(56-57-5)质谱(MS) 4-硝基喹啉-N-氧化物(56-57-5)核磁图( 1 HNMR)
  • TCI Shanghai:4-硝基喹啉-N-氧化物 4-Nitroquinoline N-Oxide,>;98.0%(T)(56-57-5)
  • MOL 文件:56-57-5.mol
  • 上游原料:硫酸 --> 乙酸 --> 硝酸 --> 过氧化氢 --> 三氟乙酸 --> 硝酸钾 --> 喹啉 --> 三氟甲磺酸
  • 检测方法:HPLC
  • color:yellow to brown
  • 存储注意事项:光敏感

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Isoquinolines 异喹啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinaldines 奎纳丁
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinazolines 喹唑啉
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. N - Alphabetic
  5. NA - NI - N
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Environmental Standards - Chromatography
  5. Volatiles/ Semivolatiles - Environmental Standards
  6. Alpha Sort - Volatiles/ Semivolatiles
  7. N-O - Alpha Sort
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Quinolines 喹啉
  5. C8 to C10 - Quinolines
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Quinolines 喹啉
  1. Functional Group 官能团索引
  2. N-oxide

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