DIIodohydroxyquinoline 5,7-二碘喹啉-8-醇

CAS 83-73-8 MFCD00006789

化学结构图

83-73-8
SMILES: Oc1c(I)cc(I)c2cccnc12

化学属性

Mol. FormulaC9H5I2NO
Mol. Weight397
Melting Point>200
Appearance 微黄色至黄棕色细微结晶性粉末。熔点约214℃(分解)。微溶于乙醇,极微溶于水。无臭,无味。

别名和识别编码

Chemical NameDIIodohydroxyquinoline
CAS Number83-73-8
Synonym 5,7-DIIODOOXINE 5,7-Diiod-8-hydroxyc 5,7-Diiodo-8-quinolinol 5,7-Diiodoquinolin-8-ol 5,7-diiodo-8-quinolinol 5,7-diiodoquinolin-8-ol 8-Hydroxy-5,7-diiodoquinoline 8-quinolinol, 5,7-diiodo- Diamoebin Diiodhydroxychinolin Diiodohydroxyguinoline Diiodohydroxyquin Diiodohydroxyquinoline Diiodoquin Dinoleine Diodoquin Diodoxylin Diodoxyquinoline Diquinol Direxiode Disoquin Dyodin Entero Diyod Entero-Diyod EnteroDiyod Enterodiamoebin Enterosept Entodiba Fluoraquin Iodoquinol Ioquin suspension Moebiquin Quinadome Sebaquin Yod
MDL NumberMFCD00006789
PubChem Substance ID3728
EC Number201-497-9
Reaxys-RN153639
Merck Number5042
Chemical Name Translation5,7-二碘喹啉-8-醇
Wiswesser Line NotationT66 BNJ GI II JQ
Beilstein Registry Number0153639
LabNetwork Molecule IDLN00192275
InChIInChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
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分类

  • Building Blocks, C8 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinolines
  • {uni_hamburg} no charge; nitrogen heterocycle; carbocycle; aromatic; large ring; fused rings; 6ring; 10ring; alcohol; 1fragment
  • {SNA} Building Blocks, C8 to C10, Chemical Synthesis, Halogenated Heterocycles, Heterocyclic Building Blocks, Quinolines

产品应用

  • Antiamebic.

相关文献及参考

  • Lawrence, S., et al.: J. Biol. Chem., 284, 35807 (2009),
  • Merck 14 ,5042
  • Beil. 21 ,II,58
  • Corp MSDS 1 (1), 1285:B / FT-IR 2 (3), 3915:D / IR-Spectra (3), 1390:B / IR-Spectra (2), 1211:G / NMR-Reference 2 (2), 739:B / RegBook 1 (2), 2619:F / Sax 6 , 1080 / Structure Index 1 , 413:B:4
  • Short: IV/20A Title: Vapor Pressure and Antoine Coefficients for Hydrocarbons and Sulfur-, Selenium-, Tellurium-, and Halogen-Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20A Year: 1999 Keyword: organic compounds; vapor pressure ISBN: 3-540-64735-X ISBN: 978-3-540-64735-5 Internet Resource: DOI:10.1007/b71086 RefComment: VIII, 373 pages.
  • Short: IV/20B Title: Vapor Pressure and Antoine Coefficients for Oxygen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20B Year: 2000 Keyword: organic compounds; vapor pressure ISBN: 3-540-64968-9 ISBN: 978-3-540-64968-7 Internet Resource: DOI:10.1007/b71424 RefComment: VII, 320 pages.
  • Short: IV/20C Title: Vapor Pressure and Antoine Coefficients for Nitrogen Containing Organic Compounds Author: Dykyj, J.; Svoboda, J.; Wilhoit, R.C.; Frenkel, M.; Hall, K.R. Editor: Hall, K.R. Source: Landolt-Börnstein, New Series Volume: IV/20C Year: 2001 Keyword: organic compounds; vapor pressure ISBN: 3-540-41060-0 ISBN: 978-3-540-41060-7 Internet Resource: DOI:10.1007/b88812 RefComment: VII, 197 pages
  • Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15

安全信息

WGK Germany3
GHS Symbol
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352
  • P302+P352+P332+P313+P362+P364
  • P304+P312
  • P304+P340
  • P305+P351+
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H332 Harmful if inhaled 吸入有害
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xn
RTECSVC5775000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
Packing GroupIII
Hazard Class6.1(b)
UN Number 3249
Storage condition 储存温度2-8℃
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   AJTMAQ American Journal of Tropical Medicine.  (Baltimore, MD)  V.1-31,
   1921-51.  For publisher information, see AJTHAB.  Volume(issue)/page/year:
   24,29,1944

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >40 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 3,44,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 56 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03304

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 120 gm/kg/2Y-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,261,1966

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSE

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 260 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 188,111,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,219,1989

其他信息

  • 图谱信息:5,7-二碘-8-羟基喹啉(83-73-8)核磁图( 1 HNMR) 5,7-二碘-8-羟基喹啉(83-73-8)质谱(MS) 5,7-二碘-8-羟基喹啉(83-73-8)红外图谱(IR2) 5,7-二碘-8-羟基喹啉(83-73-8)核磁图( 13 CNMR) 5,7-二碘-8-羟基喹啉(83-73-8)红外图谱(IR1)
  • 用途一:用作抗阿米巴药、防腐药、金属螯合剂、阳离子分析试剂。双碘喹啉以及喹碘仿、氯碘喹啉都是卤化8-羟喹啉类肠道内抗阿米巴药,对阿米巴痢疾有效,对肠道外阿米巴原虫无影响。近年国外报道本类药物能引起亚急性脊髓视神经病,故在日本和美国已禁用。但双碘喹啉引起此病比氯碘喹啉较少见。
  • 5,7-二碘-8-羟基喹啉价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D1736 5,7-二碘-8-羟基喹啉 5,7-Diiodo-8-hydroxyquinoline 25G 351元
  • Sigma Aldrich:83-73-8(sigmaaldrich)
  • MOL 文件:83-73-8.mol
  • 上游原料:8-羟基喹啉
  • MSDS 信息:5,7-Diiodo-8-quinolinol(83-73-8).msds
  • 方法一:由8-羟基喹啉经碘化而得。
  • TCI Shanghai:5,7-二碘-8-羟基喹啉 5,7-Diiodo-8-hydroxyquinoline,>;98.0%(T)(83-73-8)

系列性分类


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