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• 试剂商城
• 直接询价

分类

• {SNA} Building Blocks, Chemical Synthesis, Coumarins, Heterocyclic Building Blocks, Wavelength Index, 发光化合物及其检测, 生化试剂
• {SNA} Biochemicals and Reagents, Building Blocks, Chemical Synthesis, Coumarins, Heterocyclic Building Blocks, Luminescent Compounds/Detection, Wavelength Index
• {SNA} Analytical Standards,
• {SA} Biochemicals and Reagents, Building Blocks, Chemical Synthesis, Coumarins, Detection, Fluorescent Probes, Labels, Particles and Stains, Heterocyclic Building Blocks
• {SNA} Analytical Standards, EP Standards, EP Standards G - H, Pharmacopeia Metrological Institutes Standards,

产品应用

• 适用于做激光染料，荧光测定酶活性的标准。测定硝酸的指示剂。

相关文献及参考

• Short: II/3
• Standard for fluorimetric determination of enzyme activity: Anal. Biochem., 54, 40; 55, 85 (1973).
• Merck: 14,4854 Beilstein:18,31
• Merck: 14,4854
• Short: II/27B
• Clin. Chim. Acta., 39, 49 (1972); Anal. Biochem., 54, 40 (1973); J. Biochem. Biophys. Methods 19, 207 (1989).

安全信息

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3850 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 5,1619,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2850 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Sense Organs and Special Senses (Eye) - ptosis
   Beha

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Vol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1500 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,403,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,413,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 6 gm/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,403,1970

其他信息

• 方法一:由间苯二酚与乙酰乙酸乙酯经环合反应而得。将浓硫酸冷至10℃以下，于搅拌下滴加由间苯二酚与乙酰乙酸乙酯配成的溶液，滴完后放置12h。然后将反应物投入有碎冰的水中，将析出的沉淀滤出，用稀氢氧化钠溶液及稀硫酸精制而得成品。
• 图谱信息:4-甲基伞形酮(90-33-5)红外图谱(IR2) 4-甲基伞形酮(90-33-5)质谱(MS) 4-甲基伞形酮(90-33-5)红外图谱(IR1)
• 上游原料:乙酰乙酸乙酯 --> 稀硫酸 --> 间苯
• 羟甲香豆素:4-甲基伞形酮又称为羟甲香豆素、胆通，是一种新型利胆药，属香豆素衍生物，常温下为白色或类白色结晶性粉末，无臭，无味。不溶于水，略溶于甲醇、乙醇，易溶于氢氧化钠溶液，对胆道口括约肌有舒张作用，具有较强的解痉、 镇痛作用，同时也能温和、持续地促进胆汁分泌，加强胆囊收缩和抑菌作用，具有明显的利胆作用，有利于结石排出，对胆总管结石有一定排石效果。尚可降低肝酶，使之恢复正常。临床主要用于胆囊炎、胆道感染、胆结石、胆道术后综合征。部分原有丙氨酸氨基转移酶升高的患者，服药后随炎症的消除而恢复正常，个别有头晕、腹胀、胸闷、皮疹、腹泻等，停药后自行消失。大剂量可引起胆汁过度分泌与腹泻。梗阻性和传染性黄疸性肝炎者慎用。
• 4-甲基伞形酮价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0453 4-甲基伞形酮 4-Methylumbelliferone 25G 150元 2014/06/02 M0453 4-甲基伞形酮 4-Methylumbelliferone 500G 1450元 2010/06/21 405490250 4-甲基伞形酮 7-Hydroxy-4-methylcoumarin , pure, laser grade 25 GR 294元
• 用途二:用作医药中间体
• TCI Shanghai:4-甲基伞形酮 4-Methylumbelliferone,>;98.0%(T)(90-33-5)
• Acros Organics:7-羟基-4-甲基香豆素 7-Hydroxy-4-methylcoumarin, pure, 97%(90-33-5)
• 用途三:适用于做激光染料，荧光测定酶活性的标准。测定硝酸的指示剂。
• Hazard Note:Irritant
• color:off-white to yellow
• Sigma Aldrich:90-33-5(sigmaaldrich)
• 微溶于水，溶于浓硫酸溶液，部分溶于5%的Na2CO3溶液，部分溶于乙醇和异丙醇。与浓硫酸作用呈蓝色荧光。
• 用途一:该品为利胆药，又是抗过敏药色甘酸钠的中间体
• MOL 文件:90-33-5.mol
• 检测方法:HPLC,NMR
• Alfa Aesar:4-甲基7－羟基香豆素,97% 4-Methylumbelliferone, 97%(90-33-5)
• 下游产品:8-乙酰基-7-羟基-4-甲基-2H-1-苯并吡喃-2-酮
• MSDS 信息:7-Hydroxy-4-methylcoumarin(90-33-5).msds