Hexamethyldisiloxane HMDSO 六甲基二硅氧烷

CAS 107-46-0 MFCD00008265

化学结构图

107-46-0
SMILES: C[Si](C)(C)O[Si](C)(C)C

化学属性

Mol. FormulaC6H18OSi2
Mol. Weight162
Density0.764
Refractive index1.3760 to 1.3790
Flash Point-2°C(lit.)
TSCAYes
Boiling Point101
Melting Point-59
Vapor Density>;1 (vs air)
Solubility不溶于水，溶于多数有机溶剂。
Stability对湿度敏感
Danger-Level-
pH-:-
Redox-

别名和识别编码

Chemical NameHexamethyldisiloxane
MDL NumberMFCD00008265
CAS Number107-46-0
EC Number203-492-7
Beilstein Registry Number1736258
Synonym 1,1,1,3,3,3-Hexamethyl-disiloxane Fluka AG HMDSO HMDSO 六甲基二硅氧烷 Hexamethyldisiloxane SILICONE FLUID SWS-F 221 Silane, oxybis(trimethyl- belsildm0.65 六甲基乙硅氧烷 六甲基二硅氧烷, 98+%
PubChem Substance ID87570539
Reaxys-RN1736258
Chemical Name Translation六甲基二硅氧烷
Wiswesser Line Notation1-SI-1&1&O-SI-1&1&1
LabNetwork Molecule IDLN00196011
InChIInChI=1S/C6H18OSi2/c1-8(2,3)7-9(4,5)6/h1-6H3
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分类

  • {SNA} Chemical Synthesis, Organometallic Reagents, Organosilicon, Siloxanes
  • {S
  • {SNA} Derivatization Reagents, Derivatization Reagents GC, Reagents for Silylation, Silylation Reagents, 分析/色谱, 分析试剂
  • {SNA} Analytical Reagents, Analytical/Chromatography,
  • {SNA} Bioelectronics, Chemical Synthesis, Homopolymers, Materials Science, Methyl (CH3) Terminated PDMS, Microfluidics, Organometallic Reagents, Organosilicon, PDMS, PDMS and Silicone Polymers, Polymer Science, Polymers, Polysiloxanes, Silicones, Siloxanes
  • {SNA} Bioelectronics,

产品应用

  • 用作硅油生产中的封头剂，也可用作硅氮烷原料。用于硅橡胶、药品、气相色谱固定液、分析试剂、憎水剂等。

相关文献及参考

  • Merck: 14,10497 Beilstein:4(3)1859
  • Reacts with P2O5 to give trimethylsilyl polyphosphate ('PPSE'), a milder and more convenient dehydrating agent then polyphosphoric acid. For examples, and related reagents, see Phosphorus(V)­ oxide, A13348.
  • Merck: 14,10497
  • Silylates primary and sec-alcohols and phenols, in the presence of p-TsOH as catalyst. If the substrate contains acid-sensitive groups, PPTS can be used: Tetrahedron Lett., 4261 (1978). See Appendix 4.
  • In the presence of FeCl3, reacts with benzotrichlorides to give substituted benzoyl chlorides in good yields: J. Chem. Soc., Chem. Commun., 808 (1977).

安全信息

Signal word Danger
GHS Symbol
WGK Germany2
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
Risk Statements
  • R11 Highly flammable 非常易燃
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P303+P361+P353
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P370+P378
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
RTECSJM9237000
Packing GroupII
UN Number 1993 UN 1993 3/PG 2
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes 3 F,N
Hazard Class3
Storage condition Flammables area 充氩保存
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effec

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 16 mL/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis with appropriate
   anesthesia
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,590,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8 mL/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,590,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 30,332,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent k

Restrict -

其他信息

  • 用途四:用于仪器仪表循环冷却液和制造各类有机硅产品，也作憎水剂，用于纤维织物表面处理，无线电零件的绝缘防潮。还用于气相色谱固定液。
  • 海关编码:29310095
  • 毒性分级:中毒
  • 用途二:作为封头剂、清洗剂、脱膜剂，主要用于有机化工及医药生产中
  • 急性毒性:口服- 大鼠 LDL0: 8 毫升/ 公斤; 腹腔- 小鼠 LD50: 4500 毫克/ 公斤
  • 存储注意事项:湿度敏感;氮气保护
  • F:10
  • 危险标记:7(易燃液体)
  • 检测方法:GC,NMR
  • 灭火剂:干粉、干砂、二氧化碳、泡沫
  • 用途五:107-46-0（六甲基二硅氧烷）用作硅油、硅橡胶、药品、气相色谱固定液体 、分析试剂、憎水剂等
  • 用途六:用作硅油生产中的封头剂，也可用作硅氮烷原料。用于硅橡胶、药品、气相色谱固定液、分析试剂、憎水剂等。
  • 图谱信息:六甲基二硅氧烷(107-46-0)红外图谱(IR1) 六甲基二硅氧烷(107-46-0)质谱(MS) 六甲基二硅氧烷(107-46-0)核磁图( 13 CNMR) 六甲基二硅氧烷(107-46-0)核磁图( 1 HNMR)
  • 类别:易燃液体
  • 刺激数据:皮肤- 兔子 500 毫克/ 24小时 轻度
  • 上游原料:三甲基氯硅烷 --> N-甲基苯胺 --> 101
  • 溶于有机溶剂，不溶于水。
  • TSCA:Yes
  • Acros Organics:六甲基二硅氧烷 Hexamethyldisiloxane, 98+%(107-46-0)
  • 蒸气密度:>;1 (vs air)
  • MSDS 信息:六甲基二硅醚(107-46-0).msds
  • 可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生刺激烟雾
  • 用途一:本品作为封头剂、清洗剂、脱膜剂，主要用于有机化工及医药化工生产中。
  • TCI Shanghai:六甲基二硅氧烷 Hexamethyldisiloxane,>;98.0%(GC)(107-46-0)
  • MOL 文件:107-46-0.mol
  • 下游产品:2-(三氟甲基)噻唑-5-甲酸乙酯 --> 碘代三甲硅烷 --> 叶黄素
  • Sigma Aldrich:107-46-0(sigmaaldrich)
  • 用途三:用作憎水剂、绝缘材料及防潮剂
  • 方法一:将62.49g（0.575mol）三甲基氯硅烷滴加至72.7g（0.06mol）N,N-二甲基苯胺和7g水组成的溶液中，加热回流1h。常压蒸馏，收集98-101℃馏分，经干燥即为六甲基二硅醚，得43-44g，收率92-94%。工业生产是将三甲基氯硅烷在30-40℃水解。
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 注意事项:贮存时，不准接触明火，应保持通风、干燥，防止阳光照射，贮存温度-50℃～45℃。 运输时，应避免碰撞，防雨淋、日晒，按危险品贮存和运输。
  • Alfa Aesar:六甲基二硅氧烷,NMRgrade,99.7% Hexamethyldisiloxane, NMR grade, 99.7%(107-46-0)
  • 六甲基二硅氧烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 40027880 六甲基二硅醚;六甲基氧二硅烷;六甲基二硅氧烷 100ml 751元 2011/08/23 M81405101 六甲基二硅醚;六甲基氧二硅烷;六甲基二硅氧烷 100ml 635元 2011/04/16 H0091 六甲基二硅氧烷 Hexamethyldisiloxane 25ML 208元
  • 外观性质:无色、透明液体, 易潮解。

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Stable Isotopes 稳定同位素
  3. Alphabetical Listings for Stable Isotope Labeled Products
  4. G-H - Alphabetical Listings
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Spectroscopy - Analytical Standards
  4. NMR - Spectroscopy
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Derivatization Reagents GC - Derivatization Reagents
  5. Reagents for Silylation - Derivatization Reagents GC
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  4. Siloxanes - Organosilicon
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  4. Siloxanes - Organosilicon
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. H - Alphabetic
  5. HA -HT - H
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  4. Silanes 硅烷
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Silicon Compounds for Organic Synthesis 硅化合物
  1. Analytical & Chromatography 分析化学与色谱
  2. Gas Chromatography (GC) 气相色谱
  3. Packed GC Columns and Components - Gas Chromatography (GC)
  4. Stationary Phases
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Reagents
  3. Derivatization Reagents 衍生分析试剂
  4. Fluka Reagents
  1. Analytical & Chromatography 分析化学与色谱
  2. Stable Isotopes 稳定同位素
  3. Deuterated NMR Solvents and Reagents
  4. NMR - Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Fluorescent agents, general
  1. Chemical Synthesis 化学合成
  2. Organometallic Reagents 金属有机试剂
  3. Organosilicon 有机硅
  4. Silicates
  1. Analytical & Chromatography 分析化学与色谱
  2. Derivatization Reagents
  3. Derivatization Reagents GC
  4. Reagents for Alkylation & Esterification
  1. Analytical & Chromatography 分析化学与色谱
  2. Gas Chromatography (GC) 气相色谱
  3. Derivatization Reagents
  4. Reagents for Alkylation & Esterification