Fluocinolone Acetonide 氟氢松

CAS 67-73-2 MFCD00010525

化学结构图

67-73-2
SMILES: CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

化学属性

Mol. FormulaC24H30F2O6
Mol. Weight452.49
Melting Point267-269 °C
TSCANo
Refractive index103 ° (C=1, MeOH)
SolubilityDMSO 90 mg/mL Water <1 mg/mL Ethanol 12 mg/mL
Boiling Point578.5±50.0 °C at 760 mmHg

别名和识别编码

Chemical NameFluocinolone Acetonide
CAS Number67-73-2
Synonym Fluocinolone (Acetonide) {LY} Fluocinolone (Acetonide) {} {LY} Fluocinolone (Acetonide) {} {} {LY} Fluocinolone (Acetonide) {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Fluocinolone (Acetonide) {} {} {} {} {} {} {} {} {} {} {
MDL NumberMFCD00010525
PubChem Substance ID24894978
EC Number200-668-5
Merck Number4150
Reaxys-RN1358395
Beilstein Registry Number19(5)6,571
Chemical Name Translation氟氢松
Wiswesser Line NotationT F5 E5 B666 GO IO RV AHTTTT&J A BF CQ E FVIQ H H OF-A&BHO -B&ACEF
LabNetwork Molecule IDLN00352120
Canonical SMILESO=C([C@]([C@@]1([H])C[C@@]2([H])[C@@](C[C@H](F)C3=CC4=O)([H])[C@@](F)([C@]3(C=C4)C)[C@@H](O)C5)(OC(C)(C)O1)[C@]25C)CO
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分类

  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, F, FA - FL, Forensic and Veterinary Standards, Neat Compounds, Steroid
  • {SNA} Additional Standards, Analytical Standards, Chemical Structure, Chromatography, Drugs & Metabolites, Drugs of Abuse, Forensic and Veterinary Standards, Neat Compounds, Steroid, 分析/色谱
  • {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Chemical Structure, Chromatography,

产品应用

  • A synthetic glucocorticoid VEGF inhibitor.

相关文献及参考

  • [2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.
  • Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),
  • Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964),
  • [1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide
  • [1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide
  • [2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.

安全信息

GHS Symbol
Precautionary statements
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P332+P313
  • P302+P350
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P337+P313
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Warning
RTECSTU3830000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xn Xi Xi,Xn
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S37 Wear suitable gloves 戴适当手套；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 103 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 108 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,694,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,694,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,694,1982

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 10 gm/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 4,653,1983

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   19,1471,1970

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 40 ug/kg
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   17,331,1977

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   19,1471,1970

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 620 ug/L
REFERENCE :
   AETODY Advances in Modern Environmental Toxicology.  (Senate Press, Inc.,
   P.O. Box 252, Princeton Junction, NJ 08550)  V.1-    1980-
   Volume(issue)/page/year: 1,241,1980

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Administration onto the skin
TEST SYSTEM             : Human
DOSE/DURATION           : 2000 ppm
REFERENCE :
   ARDEAC Archives of Dermatology.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1 mg/kg
SEX/DURATION            : female 1-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,2102,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1200 ug/kg
SEX/DURATION            : female 8-31 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 27,2102,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1625 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 37,43,1987

其他信息

  • 醋酸肤轻松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 F0657 乙酸肤轻松 Fluocinolone Acetonide 5G 4330元 2014/06/02 F0657 乙酸肤轻松 Fluocinolone Acetonide 1G 1120元
  • 醋酸肤轻松价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 F0657 乙酸肤轻松 Fluocinolone Acetonide 5G 3410元 2011/04/16 F0657 乙酸肤轻松 Fluocinolone Acetonide 1G 971元
  • MSDS 信息:6a,9a-Fifluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione(67-73-2).msds
  • MOL 文件:67-73-2.mol
  • 醋酸氟轻松
  • Fluocinolone Acetonide是一种皮质类固醇，与胞浆中糖皮质激素受体结合。
  • 用途一:用于过敏性皮炎、接触性皮炎、脂溢性皮炎及湿疹等。
  • 醋酸氟轻松:醋酸氟轻松为合成的、含氟强效的类固醇。外用可使真皮毛细血管收缩，抑制表皮细胞增殖或再生，抑制结蒂组织内纤维细胞的新生，稳定细胞内溶酶体膜，具有抗炎、止痒的作用。外用后可通过完整的皮肤吸收。吸收后与系统给予皮质类固醇在体内的代谢一样，主要在肝脏代谢，经肾脏排出。醋酸氟轻松适用于对皮质类固醇有效的皮肤病，如湿疹(特别是婴儿湿疹)、神经性皮炎、皮肤瘙痒症、接触性皮炎、牛皮癣、盘状红斑狼疮、扁平苔癣、外耳炎、日光性皮炎等。但需要注意长期或大面积使用可引起皮肤萎缩、毛细血管扩张，发生痤疮样皮炎、口周皮炎、毛囊炎，增加对感染的易感性等。偶可引起变态反应接触性皮炎。
  • 理化性质:白色或类白色结晶性粉末，无臭，无味。[α]D20+80—+88° (二氧六环)。溶于丙酮，略溶于乙醇、二氧六环，不溶于水、石油醚。由11α-羟基 -16α，17α-环氧孕甾烷-4-烯-3，20-二酮经磺酯化、开环等16步反应而得。用于过敏性皮炎，接触性皮炎、湿疹等皮肤病。
  • 皮质激素类药物:醋酸肤轻松 又称醋酸氟轻松、氟西奈德、氟去炎舒松、肤轻松、氟轻松、仙乃乐、丙酮化氟新龙，为目前我国外用皮质激素中疗效最显著而副作用较小的一种，可使真皮毛细血管收缩，抑制结缔组织细胞增殖或再生;还可稳定细胞内溶酶体膜，防止细胞内溶酶体酶释放组胺而引起组织损伤。其抗炎作用为氢化可的松的100倍，使用最低浓度 (0.025%) 即有明显功效，且奏效迅速、能在数日内显著减轻或痊愈，止痒作用较好。醋酸肤轻松主要用于用于对糖皮质激素有效的皮肤病，如接触性皮炎、特应性皮炎、脂溢性皮炎、神经性皮炎、日光性皮炎、湿疹(特别是婴儿湿疹)、皮肤瘙痒症、银屑病、盘状红斑狼疮、扁平苔藓、外耳炎等。与新霉素等抗菌素配伍可治疗化脓性皮肤病。以0.025-0.05%软膏，洗剂涂于拭净的患部，每日2-3次，可轻揉促其渗入皮肤。
  • TCI Shanghai:乙酸肤轻松 Fluocinolone Acetonide,>;98.0%(LC)(67-73-2)
  • Sigma Aldrich:67-73-2(sigmaaldrich)

系列性分类

  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Forensic and Veterinary Standards - Chromatography
  5. Drugs &amp; Metabolites - Forensic and Veterinary Standards
  6. Neat Compounds - Drugs &amp; Metabolites
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FA - FL - F
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Alphabetic - Analytical Standards
  4. F - Alphabetic
  5. FA - FL - F
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Glucocorticoid Receptor  (糖皮质激素受体)

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