3-Methyladenine 6-氨基-3-甲基嘌呤

CAS 5142-23-4 MFCD00010531

化学结构图

5142-23-4
SMILES: Cn1cnc(N)c2ncnc1-2

化学属性

Mol. FormulaC6H7N5
Mol. Weight149.15
Density1.60
Melting Point300°C
Flash Point99°C
Boiling Point240.1°C at 760 mmHg
TSCANo
SolubilityDMSO 4 mg/mL Water <1 mg/mL Ethanol 4 mg/mL

别名和识别编码

Chemical Name3-Methyladenine
CAS Number5142-23-4
Synonym 3-Methyladenine {LY} 3-Methyladenine {} {LY} 3-Methyladenine {} {} {LY} 3-Methyladenine {} {} {} {LY} 3-Methyladenine {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 3-Methyladenine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
EC Number225-908-6
Beilstein Registry Number146087
MDL NumberMFCD00010531
PubChem Substance ID253660841
Chemical Name Translation6-氨基-3-甲基嘌呤
Reaxys-RN146087
InChIKeyFSASIHFSFGAIJM-UHFFFAOYSA-N
LabNetwork Molecule IDLN00331106
Canonical SMILESNC1=C2N=CN=C2N(C)C=N1
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分类

  • Bases & Related Reagents
  • {SNA} Autophagy, Autophagy Inhibitors, Biochemicals and Reagents, Cell Signaling and Neuroscience, Core Bioreagents, Nucleoside Analogs, Nucleosides and Nucleotides, Nucleosides, Nucleotides, Oligonucleotides, Research Essentials, 细胞生物学
  • Nucleotides
  • Inhibitors
  • Heterocycles
  • {SNA} Autophagy, Autophagy Inhibitors,

产品应用

  • 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concen

相关文献及参考

  • [2]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
  • [3]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 2016;2016:8369704.
  • Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006),
  • Hayat, M., et al.: Oncologist, 12, 20 (2007),
  • Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001),
  • [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.
  • [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.
  • [2]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
  • [3]. Wang X, et al. Acanthopanax

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P302+P352+P332+P313+P362+P364
  • P332+P313
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P305+P351+P338+P337+P313
RTECSAU6520000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 46(5),104,1983

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleoside Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleosides - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotide Analogs - Nucleosides, Nucleotides, Oligonucleotides
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Nucleosides, Nucleotides, Oligonucleotides - Biochemicals and Reagents
  4. Nucleotides - Nucleosides, Nucleotides, Oligonucleotides
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Purines 嘌呤
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nucleic Acid Electrophoresis
  4. Nucleic Acid Gel Stains
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nucleosides, Nucleotides, Oligonucleotides
  4. NAD and Analogs
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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