3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)benzamide 甲泛葡胺

CAS 31112-62-6 MFCD00010577

化学结构图

31112-62-6
SMILES: CC(=O)N(C)C1C(I)=C(C(I)=C(NC(C)=O)C=1I)C(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O

化学属性

Mol. FormulaC18H22I3N3O8
Mol. Weight789.13
Melting Point222-224 °C (dec.)(lit.)

别名和识别编码

Chemical Name3-acetamido-2,4,6-triiodo-5-(N-methylacetamido)-N-((3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)benzamide
CAS Number31112-62-6
Synonym 2-[[3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl]amino]-2-deoxy-D-glucose Metrizamide Amipaque Telebrix 300 3-Acetylamino-5-N-methyl-acetylamino-2,4,6-triiodobenzoyl glucosamine 2-[3-Acetamido-5-(N-methylacetamido)-2,4,6-triiodobenzamido]-2-deoxy-D-glucose Metrizamide, mixture of anomers 2-((3-(Acetylamino)-5-(acetylmethylamino)-2,4,6-triiodobenzoyl)amino)-2-deoxy-D-glucose 2-(3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido)-2-deoxy-D-glucopyranose 2-(3-Acetamido-5-N-methyl-acetamido-2,4,6-triiodobenzamido)-2-deoxy-D-glucose 2-(3-Acetamido-2,4,6-triiodo-5-(N-methylacetamido)benzamido)-2-deoxy-D-glucose D-Glucose,
MDL NumberMFCD00010577
Beilstein Registry Number6758226
EC Number250-475-5
Chemical Name Translation甲泛葡胺
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分类

  • Amines
  • Carbohydrates & Derivatives
  • Diagnostic
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Metrizamide is a X-ray contrast agent related to Metrizoic Acid (M338935). Metrizamide is used as an diagnostic aid (radiopaque medium).

相关文献及参考

  • Salvesen, S., et al.: Radiology, 123, 241 (1977),
  • Dibona, G.F., et al.: Ann. Radiol., 22, 195 (1979),

安全信息

WGK Germany2
RTECSLZ6650000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2910 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4001323

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9950 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #4001323

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Brain and Coverings - recordings from specific areas of CNS
   Behavioral - anticonvulsant
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   RADLAX Radiology.  (Radiological Soc. of North America, 20th & Northampton
   Sts., Easton, PA 18042) V.1-    1923-  Volume(issue)/page/year: 140,713,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 21763 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARASA5 Acta Radiologica, Supplementum.  (Acta Radiologica, POB 7449, S-10391
   Stockholm, Sweden) No.1-    1921-  Volume(issue)/page/year: 335,5,1973

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TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 54008 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - other measures of fertility
REFERENCE :
   NIIHAO Nichidoku Iho.  Japanese-German Medical Reports.  (Nihon Scheringu
   K.K, Gakujutsubu, 6-64, Nishimiyahara, 2-chome, Yodogawa-ku, Osaka 532,
   Japan)  V.1-    1956-  Volume(issue)/page/year: 24,287,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11456 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   NIIHAO Nichidoku Iho.  Japanese-German Medical Reports.  (Nihon Scheringu
   K.K, Gakujutsubu, 6-64, Nishimiyahara, 2-chome, Yodogawa-ku, Osaka 532,
   Japan)  V.1-    1956-  Volume(issue)/page/year: 24,277,1979

TYPE OF TEST            : TDLo - Lowes

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 34369 mg/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NIIHAO Nichidoku Iho.  Japanese-German Medical Reports.  (Nihon Scheringu
   K.K, Gakujutsubu, 6-64, Nishimiyahara, 2-chome, Yodogawa-ku, Osaka 532,
   Japan)  V.1-    1956-  Volume(issue)/page/year: 24,277,1979

系列性分类

  1. Functional Group 官能团索引
  2. hemiacetal

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